DE60310695D1 - Amphiphile diblock-, triblock- und sternblockcopolymere und und diese enthaltende arzneimittel - Google Patents

Amphiphile diblock-, triblock- und sternblockcopolymere und und diese enthaltende arzneimittel

Info

Publication number
DE60310695D1
DE60310695D1 DE60310695T DE60310695T DE60310695D1 DE 60310695 D1 DE60310695 D1 DE 60310695D1 DE 60310695 T DE60310695 T DE 60310695T DE 60310695 T DE60310695 T DE 60310695T DE 60310695 D1 DE60310695 D1 DE 60310695D1
Authority
DE
Germany
Prior art keywords
amphiphiles
diblock
triblock
medicaments containing
starblock copolymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60310695T
Other languages
English (en)
Other versions
DE60310695T2 (de
Inventor
Bhalchandra Shripad Lele
Jean-Christophe Leroux
Meriam Kabbaj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labopharm (barbados) Ltd Belleville St Mic Bb
Labopharm Inc
Paladin Labs Europe Ltd
Original Assignee
Labopharm Barbados Ltd
Labopharm Inc
Paladin Labs Europe Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labopharm Barbados Ltd, Labopharm Inc, Paladin Labs Europe Ltd filed Critical Labopharm Barbados Ltd
Publication of DE60310695D1 publication Critical patent/DE60310695D1/de
Application granted granted Critical
Publication of DE60310695T2 publication Critical patent/DE60310695T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
DE60310695T 2002-03-18 2003-03-17 Amphiphile diblock-, triblock- und sternblockcopolymere und und diese enthaltende arzneimittel Expired - Lifetime DE60310695T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US101093 2002-03-18
US10/101,093 US7018655B2 (en) 2002-03-18 2002-03-18 Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
PCT/CA2003/000376 WO2003078489A1 (en) 2002-03-18 2003-03-17 Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions

Publications (2)

Publication Number Publication Date
DE60310695D1 true DE60310695D1 (de) 2007-02-08
DE60310695T2 DE60310695T2 (de) 2007-09-13

Family

ID=28039961

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60310695T Expired - Lifetime DE60310695T2 (de) 2002-03-18 2003-03-17 Amphiphile diblock-, triblock- und sternblockcopolymere und und diese enthaltende arzneimittel

Country Status (6)

Country Link
US (1) US7018655B2 (de)
EP (1) EP1487892B1 (de)
AU (1) AU2003212158A1 (de)
DE (1) DE60310695T2 (de)
ES (1) ES2278145T3 (de)
WO (1) WO2003078489A1 (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
WO2003031483A1 (en) 2001-10-10 2003-04-17 The Regents Of The University Of Colorado Degradable thiol-ene polymers
AU2003230761A1 (en) * 2002-03-29 2003-10-13 Abbott Laboratories Polymeric micelle formulations of hydrophobic compounds and methods
US20070155926A1 (en) * 2003-03-28 2007-07-05 Krzysztof Matyjaszewski Degradable polymers
TWI248947B (en) * 2003-07-21 2006-02-11 Ind Tech Res Inst Biodegradable copolymer, and polymeric micelle composition containing the copolymer
GB2408207A (en) * 2003-11-24 2005-05-25 Johnson & Johnson Medical Ltd Wound dressing for the controlled release of therapeutic agents comprising also an inhibitor of a protease enzyme & a linker group cleavable by such an enzyme
US7262253B2 (en) 2003-12-02 2007-08-28 Labopharm, Inc. Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers
US20050214379A1 (en) * 2004-01-02 2005-09-29 Sandro Mecozzi Encapsulation of chemical compounds in fluorous-core and fluorous-inner-shell micelles formed from semifluorinated-block or fluorinated-block copolymers
EP1725590A4 (de) * 2004-03-05 2013-08-07 Univ Carnegie Mellon Verfahren zur atom transfer radical polymerization
US20060198891A1 (en) * 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
JP4121537B2 (ja) 2004-12-22 2008-07-23 日東電工株式会社 線維化抑制のための薬物担体および薬物担体キット
US20120269886A1 (en) 2004-12-22 2012-10-25 Nitto Denko Corporation Therapeutic agent for pulmonary fibrosis
US20080268013A1 (en) * 2005-02-10 2008-10-30 Emory University Polyethylene Oxide Polymers Including Anti-Inflammatory Glycodendrons
CA2606270A1 (en) * 2005-04-19 2006-10-26 Massachusetts Institute Of Technology Amphiphilic polymers and methods of use thereof
EP1928919B1 (de) 2005-08-23 2010-02-17 Carnegie-Mellon University Radikalische atomtransfer-polymerisation in mikroemulsion und echte emulsionspolymerisation
DE602006017416D1 (de) * 2005-08-26 2010-11-18 Univ Carnegie Mellon Polymerisationsverfahren mit katalysatorreaktivierung
US20090298676A1 (en) * 2005-10-26 2009-12-03 Michael Meier Unimolocular Micelles Containing Metal Nanoparticles and their Use as Catalyst for Synthesis of Carbon-Carbon-Bonds
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
US7811555B2 (en) * 2005-12-30 2010-10-12 Cordis Corporation Tri-branched biologically active copolymer
WO2007084126A1 (en) * 2006-01-19 2007-07-26 Allexcel, Inc. Solubilization and targeted delivery of drugs with self-assembling amphiphilic polymers
WO2008004988A1 (en) * 2006-07-06 2008-01-10 Agency For Science, Technology And Research Thermally responsive micelles
US20080026062A1 (en) * 2006-07-31 2008-01-31 Isaac Farr Pharmaceutical compositions including nano-sized active agent
US20080026040A1 (en) * 2006-07-31 2008-01-31 Isaac Farr Active agent-releasing dosage forms
JP2010504318A (ja) * 2006-09-22 2010-02-12 ラボファーム インコーポレイテッド pH標的化薬剤送達のための組成物及び方法
US8367051B2 (en) * 2006-10-09 2013-02-05 Carnegie Mellon University Preparation of functional gel particles with a dual crosslink network
US20080095847A1 (en) * 2006-10-18 2008-04-24 Thierry Glauser Stimulus-release carrier, methods of manufacture and methods of treatment
US9000048B2 (en) * 2006-11-28 2015-04-07 Wisconsin Alumni Research Foundation Fluoropolymer-based emulsions for the intravenous delivery of fluorinated volatile anesthetics
US8900562B2 (en) * 2007-01-12 2014-12-02 Wisconsin Alumni Research Foundation Semi-fluorinated block copolymers for delivery of therapeutic agents
TWI407971B (zh) 2007-03-30 2013-09-11 Nitto Denko Corp Cancer cells and tumor-related fibroblasts
GB2463198B (en) * 2007-05-23 2013-05-22 Univ Carnegie Mellon Hybrid particle composite structures with reduced scattering
WO2008148000A1 (en) 2007-05-23 2008-12-04 Carnegie Mellon University Atom transfer dispersion polymerization
TW200918099A (en) 2007-09-14 2009-05-01 Nitto Denko Corp Drug carriers
CA2635187A1 (en) 2008-06-05 2009-12-05 The Royal Institution For The Advancement Of Learning/Mcgill University Oligonucleotide duplexes and uses thereof
US8962764B2 (en) 2009-03-27 2015-02-24 Carnegie Mellon University Preparation of functional star macromolecules
CZ302830B6 (cs) 2009-12-15 2011-11-30 Ústav makromolekulární chemie AV CR, v.v.i. Vysokomolekulární polymerní nosice léciv odvozené od dendrimeru a jejich konjugáty s lécivy pro lécbu zejména pevných nádoru
EP2382966A1 (de) * 2010-03-12 2011-11-02 DSM IP Assets B.V. Mizellenzusammensetzungen und Herstellungsverfahren dafür
CN101845120B (zh) * 2010-03-25 2011-11-16 淮阴师范学院 一种温敏和生物可降解性原位凝胶的合成方法
US9644042B2 (en) 2010-12-17 2017-05-09 Carnegie Mellon University Electrochemically mediated atom transfer radical polymerization
US20140038826A1 (en) 2011-01-28 2014-02-06 The Regents Of The University Of Colorado, A Body Corporate Covalently cross linked hydrogels and methods of making and using same
US8440772B2 (en) * 2011-04-28 2013-05-14 Chevron Phillips Chemical Company Lp Methods for terminating olefin polymerizations
EP2524690A1 (de) * 2011-05-17 2012-11-21 ETH Zurich Verfahren zur Herstellung individuell angepasster Nanoteilchen, Nanoteilchen und deren Verwendung
US8445577B2 (en) * 2011-07-25 2013-05-21 Iowa State University Research Foundation, Inc. Amphiphilic multi-arm copolymers and nanomaterials derived therefrom
WO2013028756A1 (en) 2011-08-22 2013-02-28 Carnegie Mellon University Atom transfer radical polymerization under biologically compatible conditions
US9988433B2 (en) 2013-03-14 2018-06-05 Mosaic Biosciences, Inc. Covalent modification of biological macromolecules
JP6004449B2 (ja) * 2012-01-24 2016-10-05 国立大学法人 筑波大学 トリブロックコポリマー及びその使用
WO2013116791A1 (en) 2012-02-02 2013-08-08 Mosaic Biosciences, Inc. Biomaterials for delivery of blood extracts and methods of using same
JP2015509129A (ja) * 2012-02-03 2015-03-26 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション 分岐ポリマー
US9533297B2 (en) 2012-02-23 2017-01-03 Carnegie Mellon University Ligands designed to provide highly active catalyst complexes
ITRM20120169A1 (it) 2012-04-19 2013-10-20 Consiglio Nazionale Ricerche Dispositivo di rilascio di specie chimiche a controllo ottico
US10273315B2 (en) 2012-06-20 2019-04-30 Chevron Phillips Chemical Company Lp Methods for terminating olefin polymerizations
CN103965420B (zh) * 2014-04-11 2016-05-25 西北师范大学 一种基于二硫键还原响应型可降解药物载体及其制备和应用
RU2580649C1 (ru) * 2015-03-27 2016-04-10 Общество С Ограниченной Ответственностью "Научно-Производственный Центр "Амфион" Водосовместимые полимерные композиции для доставки биологически активных веществ
RU2617059C2 (ru) * 2014-11-11 2017-04-19 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова" (ФГБНУ НИИВС им. И.И. Мечникова) Способ получения амфифильных блок-сополимеров N,N-диметиламиноэтилметакрилата для доставки нуклеиновых кислот в живые клетки
US10232050B1 (en) 2014-12-12 2019-03-19 Clemson University Multi-functional particles and methods of using the same
US11633355B2 (en) 2014-12-12 2023-04-25 Clemson University Research Foundation Multi-functional particles and methods of using the same
US9982070B2 (en) 2015-01-12 2018-05-29 Carnegie Mellon University Aqueous ATRP in the presence of an activator regenerator
US10912837B2 (en) 2015-02-09 2021-02-09 Mosaic Biosciences, Inc. Degradable thiol-ene polymers and methods of making thereof
CN105213307B (zh) * 2015-09-30 2018-02-13 天津大学 用于粘液渗透的还原响应性靶向高分子胶束及其制备方法
US11174325B2 (en) 2017-01-12 2021-11-16 Carnegie Mellon University Surfactant assisted formation of a catalyst complex for emulsion atom transfer radical polymerization processes
CN108078926B (zh) * 2017-12-20 2020-07-07 临沂大学 一种肿瘤主动靶向星形两亲聚合物胶束纳米药物及其制备方法
EP3680273B1 (de) * 2019-01-08 2022-03-09 Université de Montpellier Mit photoreaktiven gruppen funktionalisierter verzweigter blockcopolymer-photovernetzer und dessen verwendung zur formgebung von degradierbaren, für medizinische und gewebetechnische anwendungen geeigneten photovernetzten elastomeren
CN110144032B (zh) * 2019-05-23 2021-10-26 西京学院 一种四臂星状聚合物及其制备方法
FI129022B (en) 2019-09-10 2021-05-14 Aabo Akademi Univ Polymer and composition made from a renewable source
CN111019109A (zh) * 2019-12-26 2020-04-17 南京林业大学 一种聚d-乳酸-异丙叉基葡萄糖双嵌段共聚物材料及其制备方法
WO2023210671A1 (ja) * 2022-04-26 2023-11-02 京セラ株式会社 共重合体、高分子膜、測定用装置および測定用担体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016332A (en) * 1972-05-01 1977-04-05 Ppg Industries, Inc. Mercaptan blocked thermosetting copolymers
US3933940A (en) * 1973-02-08 1976-01-20 Ppg Industries, Inc. Mercaptan blocked thermosetting copolymers
DE3378250D1 (en) * 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
US4565854A (en) * 1983-04-07 1986-01-21 Kuraray Co., Ltd. Polymer having thiol end group
US5342724A (en) * 1992-04-10 1994-08-30 Eastman Kodak Company Toner manufacture using chain transfer polyesters
CA2228118A1 (en) 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatments agents
KR0180334B1 (ko) 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
US6284267B1 (en) 1996-08-14 2001-09-04 Nutrimed Biotech Amphiphilic materials and liposome formulations thereof
US6060518A (en) 1996-08-16 2000-05-09 Supratek Pharma Inc. Polymer compositions for chemotherapy and methods of treatment using the same
TW520297B (en) * 1996-10-11 2003-02-11 Sequus Pharm Inc Fusogenic liposome composition and method
US6338859B1 (en) * 2000-06-29 2002-01-15 Labopharm Inc. Polymeric micelle compositions

Also Published As

Publication number Publication date
ES2278145T3 (es) 2007-08-01
EP1487892A1 (de) 2004-12-22
AU2003212158A1 (en) 2003-09-29
WO2003078489A1 (en) 2003-09-25
US20030181613A1 (en) 2003-09-25
US7018655B2 (en) 2006-03-28
EP1487892B1 (de) 2006-12-27
DE60310695T2 (de) 2007-09-13

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: LABOPHARM INC., LAVAL, QUEBEC, CA

Owner name: LABOPHARM EUROPE LTD., DUBLIN, IE

Owner name: LABOPHARM (BARBADOS) LTD., BELLEVILLE, ST. MIC, BB

8328 Change in the person/name/address of the agent

Representative=s name: SCHIEBER FARAGO, 80538 MUENCHEN

8364 No opposition during term of opposition