DE60304587D1 - Chinolyl-propylpiperidinderivate und deren verwendung als antimikrobielles mittel - Google Patents

Chinolyl-propylpiperidinderivate und deren verwendung als antimikrobielles mittel

Info

Publication number
DE60304587D1
DE60304587D1 DE60304587T DE60304587T DE60304587D1 DE 60304587 D1 DE60304587 D1 DE 60304587D1 DE 60304587 T DE60304587 T DE 60304587T DE 60304587 T DE60304587 T DE 60304587T DE 60304587 D1 DE60304587 D1 DE 60304587D1
Authority
DE
Germany
Prior art keywords
alkyl
cooh
protected
protecting group
keto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60304587T
Other languages
English (en)
Other versions
DE60304587T2 (de
Inventor
Eric Bacque
Antony Bigot
Ahmad Youssef El
Baptiste Ronan
Michel Tabart
Fabrice Viviani
Jean-Luc Malleron
Serge Mignani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novexel SA
Original Assignee
Novexel SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novexel SA filed Critical Novexel SA
Application granted granted Critical
Publication of DE60304587D1 publication Critical patent/DE60304587D1/de
Publication of DE60304587T2 publication Critical patent/DE60304587T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE60304587T 2002-09-11 2003-09-10 Chinolylpropylpiperidinderivate und deren verwendung als antimikrobielles mittel Expired - Fee Related DE60304587T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0211212 2002-09-11
FR0211212A FR2844270B1 (fr) 2002-09-11 2002-09-11 Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
PCT/FR2003/002686 WO2004024712A1 (fr) 2002-09-11 2003-09-10 Derives de la quinolyl propyl piperidine et leur utilisation en tant qu’antimicrobiens

Publications (2)

Publication Number Publication Date
DE60304587D1 true DE60304587D1 (de) 2006-05-24
DE60304587T2 DE60304587T2 (de) 2007-02-22

Family

ID=31725983

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60304587T Expired - Fee Related DE60304587T2 (de) 2002-09-11 2003-09-10 Chinolylpropylpiperidinderivate und deren verwendung als antimikrobielles mittel

Country Status (10)

Country Link
US (1) US7232834B2 (de)
EP (1) EP1542988B1 (de)
AT (1) ATE323080T1 (de)
AU (1) AU2003278296A1 (de)
CA (1) CA2503732A1 (de)
DE (1) DE60304587T2 (de)
EC (1) ECSP055644A (de)
ES (1) ES2263036T3 (de)
FR (1) FR2844270B1 (de)
WO (1) WO2004024712A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
EP2181996A1 (de) 2002-01-29 2010-05-05 Glaxo Group Limited Aminopiperidinderivate
EP1470131A2 (de) * 2002-01-29 2004-10-27 Glaxo Group Limited "aminopiperidinverbindugen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen "
AR040335A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto
TW200409637A (en) 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
AU2003291227A1 (en) 2002-11-05 2004-06-07 Smithkline Beecham Corporation Antibacterial agents
EP1560821B8 (de) 2002-11-05 2010-05-19 Glaxo Group Limited Antibakterielle wirkstoffe
TW200427688A (en) * 2002-12-18 2004-12-16 Glaxo Group Ltd Antibacterial agents
US20070254872A1 (en) * 2004-07-08 2007-11-01 Glaxo Group Limited Antibacterial Agents
US7709472B2 (en) 2005-01-25 2010-05-04 Glaxo Group Limited Antibacterial agents
WO2006081182A2 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
JP2008528598A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
WO2006081289A2 (en) * 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
WO2006081178A2 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
AU2006230364B2 (en) 2005-03-31 2012-09-13 Janssen Pharmaceutica N.V. Bicyclic pyrazole compounds as antibacterial agents
JP2009532423A (ja) 2006-04-06 2009-09-10 グラクソ グループ リミテッド 抗菌剤としてのピロロ−キノキサリノン誘導体
EP1992628A1 (de) 2007-05-18 2008-11-19 Glaxo Group Limited Derivate und Analoge von N-Ethylquinolonen und N-Ethylazaquinolonen
US8389524B2 (en) * 2007-04-20 2013-03-05 Glaxo Group Limited Tricyclic nitrogen containing compounds as antibacterial agents
EP2080761A1 (de) 2008-01-18 2009-07-22 Glaxo Group Limited Verbindungen
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
FR2936951B1 (fr) * 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
US20110275661A1 (en) 2008-10-17 2011-11-10 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
US8318940B2 (en) 2009-01-15 2012-11-27 Glaxo Group Limited Naphthyridin-2 (1 H)-one compounds useful as antibacterials
PE20170501A1 (es) 2014-08-22 2017-04-27 Glaxosmithkline Ip Dev Ltd Un procedimiento que comprende compuestos que administran a un sujeto infectado con neisseria gonorrhoeae
UY36851A (es) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd Compuestos para uso en aplicaciones antibacterianas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH533123A (de) 1968-07-02 1973-01-31 Hoffmann La Roche Verfahren zur Herstellung von Chinolinderivaten
AU2437900A (en) * 1999-01-20 2000-08-07 Smithkline Beecham Plc Piperidinylquinolines as protein tyrosine kinase inhibitors
FR2798656B1 (fr) * 1999-09-17 2004-12-17 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
FR2816618B1 (fr) * 2000-11-15 2002-12-27 Aventis Pharma Sa Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent

Also Published As

Publication number Publication date
CA2503732A1 (fr) 2004-03-25
DE60304587T2 (de) 2007-02-22
ECSP055644A (es) 2005-07-06
US20040087619A1 (en) 2004-05-06
US7232834B2 (en) 2007-06-19
FR2844270B1 (fr) 2006-05-19
EP1542988A1 (de) 2005-06-22
WO2004024712A1 (fr) 2004-03-25
ES2263036T3 (es) 2006-12-01
EP1542988B1 (de) 2006-04-12
ATE323080T1 (de) 2006-04-15
AU2003278296A1 (en) 2004-04-30
FR2844270A1 (fr) 2004-03-12

Similar Documents

Publication Publication Date Title
ECSP055644A (es) Derivados de la quinolil-propil-piperidina y su utilización
DE60303954D1 (de) Chinolyl-propylpiperidinderivate und deren verwendung als antimikrobielle wirkstoffe
ATE427302T1 (de) Arylsulphonamidderivat und deren verwendung als b1-bradykinin rezeptor antagonisten
UA41251C2 (uk) Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
RS52596B (en) SUBSTITUTED AMID DERIVATIVES AS PROTEIN KINASE INHIBITORS
NO20022314D0 (no) Stabile forbindelser av nye derivater av 3,3- difenylpropylaminer
NZ237189A (en) N-(4-piperidinyl)(dihydro benzofuran or dihydro-2h-benzopyran) carboxamide derivatives and pharmaceutical compositions
NO20065902L (no) 3-{4-(pyridin-3-yl)fenyl}-5-(1H-,1,2,3-triazol-1-ylmetyl)-1,3-oksazolidin-2-oner som antibakterielle midler
ATE284692T1 (de) Verwendung von nicht-peptidischen bradykinin- antagonisten zur herstellung von arzneimitteln zur behandlung und prävention der alzheimerischen krankheit
NO20065889L (no) 3-`4-{6-substituert alkanoyl)pyridin-3-yf}-3-fenyl!-5-(1 H-1,2,3-triazol-1-ylmetyl)-1,3-oksazolidin-2-oner som antibakterielle midler.
SI1050531T1 (en) Pyridine and piperidine derivatives for treating neurodegenerative diseases
HK1029584A1 (en) New cyano-indole serotonin-reuptake inhibitor compounds, a process for their preparation and pharmaceutical compositions containing them.
DK0717036T3 (da) Anvendelse af 5-acyl-1,4-dihydropyridiner til bekæmpelse af sygdomme i CNS
NO983439L (no) 1-(pyrazol-3-yl-etyl)-4-(indol-3-yl)-piperidin anvendt som medisin som virker på sentralnervesystemet
HUP0202237A2 (hu) Amin, módosított pszeudomicin vegyületek, azokat tartalmazó gyógyászati készítmény és alkalmazásuk

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee