DE60237512D1 - N-(aryl)-2-arylethensulfonamide und ihre therapeutischen anwendungen - Google Patents
N-(aryl)-2-arylethensulfonamide und ihre therapeutischen anwendungenInfo
- Publication number
- DE60237512D1 DE60237512D1 DE60237512T DE60237512T DE60237512D1 DE 60237512 D1 DE60237512 D1 DE 60237512D1 DE 60237512 T DE60237512 T DE 60237512T DE 60237512 T DE60237512 T DE 60237512T DE 60237512 D1 DE60237512 D1 DE 60237512D1
- Authority
- DE
- Germany
- Prior art keywords
- aryl
- arylethesulfonamides
- therapeutic applications
- agents
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- -1 for example Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000718 radiation-protective agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Indole Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27198501P | 2001-02-28 | 2001-02-28 | |
| PCT/US2002/005979 WO2002067865A2 (en) | 2001-02-28 | 2002-02-28 | N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60237512D1 true DE60237512D1 (de) | 2010-10-14 |
Family
ID=23037924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60237512T Expired - Lifetime DE60237512D1 (de) | 2001-02-28 | 2002-02-28 | N-(aryl)-2-arylethensulfonamide und ihre therapeutischen anwendungen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6646009B2 (enExample) |
| EP (1) | EP1379508B9 (enExample) |
| JP (1) | JP4171656B2 (enExample) |
| KR (1) | KR100850330B1 (enExample) |
| AT (1) | ATE479657T1 (enExample) |
| AU (1) | AU2002306604B2 (enExample) |
| CA (1) | CA2439255C (enExample) |
| DE (1) | DE60237512D1 (enExample) |
| DK (1) | DK1379508T3 (enExample) |
| IL (2) | IL157540A0 (enExample) |
| WO (1) | WO2002067865A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002069892A2 (en) * | 2001-02-28 | 2002-09-12 | Temple University Of The Commonwealth System Of Higher Education | METHOD FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY WITH α, β UNSATURATED ARYL SULFONES |
| EP1534284B1 (en) * | 2002-02-28 | 2011-07-27 | Temple University - Of The Commonwealth System of Higher Education | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders |
| ES2373945T3 (es) * | 2002-02-28 | 2012-02-10 | Temple University - Of The Commonwealth System Of Higher Education | Bencilsulfonas de (e)-2,6-dialcoxiestirilo amino sustituido sustituidas en 4 para tratar trastornos proliferativos. |
| CA2546495C (en) * | 2003-11-14 | 2012-10-09 | Temple University - Of The Commonwealth System Of Higher Education | Alpha, beta-unsaturated sulfoxides for treating proliferative disorders |
| WO2005089269A2 (en) * | 2004-03-16 | 2005-09-29 | Temple University - Of The Commonwealth System Of Higher Education | Substituted phenoxy- and phenylthio- derivatives for treating proliferative disorders |
| WO2005090297A1 (en) * | 2004-03-19 | 2005-09-29 | Biotie Therapies Corporation | Sulphonamide derivatives |
| PT2799427T (pt) | 2006-07-05 | 2018-10-16 | Fibrotech Therapeutics Pty Ltd | Compostos terapêuticos |
| JP5278968B2 (ja) | 2006-08-30 | 2013-09-04 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法 |
| KR101593708B1 (ko) * | 2007-12-21 | 2016-02-12 | 피브로테크 세라퓨틱 피티와이 엘티디 | 항섬유증 제제의 할로겐화 유사체 |
| WO2010144959A1 (en) * | 2009-06-18 | 2010-12-23 | Fibrotech Therapeutics Pty Ltd | Analogues of anti-fibrotic agents |
| EP2491030B1 (en) | 2009-10-22 | 2015-07-15 | Fibrotech Therapeutics PTY LTD | Fused ring analogues of anti-fibrotic agents |
| US9371307B2 (en) | 2011-09-12 | 2016-06-21 | The Johns Hopkins University | Serine protease inhibitors |
| WO2013056079A1 (en) * | 2011-10-13 | 2013-04-18 | The Johns Hopkins University | High affinity beta lactamase inhibitors |
| ES2863538T3 (es) | 2012-09-20 | 2021-10-11 | Univ Temple | Derivados de alquil diarilo sustituidos, métodos de preparación y usos |
| WO2017023912A1 (en) | 2015-08-03 | 2017-02-09 | Temple University - Of The Commonwealth System Of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
| CA3052036A1 (en) | 2017-02-03 | 2018-08-09 | Certa Therapeutics Pty Ltd. | Anti-fibrotic compounds |
| WO2020150439A1 (en) * | 2019-01-17 | 2020-07-23 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2531367A (en) * | 1947-07-15 | 1950-11-21 | Sharp & Dohme Inc | N-(substituted sulfonyl)-aminobenzoic acids |
| DE2118493C3 (de) | 1971-04-16 | 1980-04-30 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Aminostilbenen |
| US4035421A (en) | 1976-03-19 | 1977-07-12 | Morton-Norwich Products, Inc. | N-(3,4,-dichlorophenyl)-2-phenylethenesulfonamide |
| DE2809377A1 (de) * | 1978-03-04 | 1979-09-13 | Boehringer Mannheim Gmbh | Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| NZ238911A (en) | 1990-07-17 | 1993-10-26 | Lilly Co Eli | Furyl, pyrrolyl and thienyl sulphonyl urea derivatives, pharmaceutical compositions and intermediates therefor |
| JPH04202173A (ja) * | 1990-11-30 | 1992-07-22 | Zeria Pharmaceut Co Ltd | スルホンアミド誘導体及びそれを含有する５―リポキシゲナーゼ阻害剤 |
| AU2096895A (en) * | 1994-03-07 | 1995-09-25 | Sugen, Incorporated | Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof |
| EP0809492A4 (en) | 1995-02-17 | 2007-01-24 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
| US5780483A (en) * | 1995-02-17 | 1998-07-14 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| JP3421349B2 (ja) | 1996-02-22 | 2003-06-30 | テュラリク インコーポレイテッド | ペンタフルオロベンゼンスルホンアミドおよび類縁体 |
| US6191170B1 (en) * | 1998-01-13 | 2001-02-20 | Tularik Inc. | Benzenesulfonamides and benzamides as therapeutic agents |
| BR9913903A (pt) | 1998-09-23 | 2001-07-03 | Tularik Inc | Composto, método para tratar ou impedir um estado doentio, e, composição farmacêutica |
| US6586617B1 (en) * | 1999-04-28 | 2003-07-01 | Sumitomo Chemical Takeda Agro Company, Limited | Sulfonamide derivatives |
-
2002
- 2002-02-28 KR KR1020037011303A patent/KR100850330B1/ko not_active Expired - Fee Related
- 2002-02-28 AT AT02802229T patent/ATE479657T1/de not_active IP Right Cessation
- 2002-02-28 JP JP2002567237A patent/JP4171656B2/ja not_active Expired - Fee Related
- 2002-02-28 DE DE60237512T patent/DE60237512D1/de not_active Expired - Lifetime
- 2002-02-28 WO PCT/US2002/005979 patent/WO2002067865A2/en not_active Ceased
- 2002-02-28 IL IL15754002A patent/IL157540A0/xx unknown
- 2002-02-28 DK DK02802229.1T patent/DK1379508T3/da active
- 2002-02-28 AU AU2002306604A patent/AU2002306604B2/en not_active Ceased
- 2002-02-28 CA CA2439255A patent/CA2439255C/en not_active Expired - Fee Related
- 2002-02-28 US US10/085,826 patent/US6646009B2/en not_active Expired - Lifetime
- 2002-02-28 EP EP02802229A patent/EP1379508B9/en not_active Expired - Lifetime
-
2003
- 2003-08-21 IL IL157540A patent/IL157540A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE479657T1 (de) | 2010-09-15 |
| US6646009B2 (en) | 2003-11-11 |
| JP2004530655A (ja) | 2004-10-07 |
| DK1379508T3 (da) | 2011-01-03 |
| CA2439255A1 (en) | 2002-09-06 |
| IL157540A (en) | 2010-11-30 |
| WO2002067865A3 (en) | 2003-03-20 |
| IL157540A0 (en) | 2004-03-28 |
| KR100850330B1 (ko) | 2008-08-04 |
| US20020165412A1 (en) | 2002-11-07 |
| CA2439255C (en) | 2011-01-04 |
| KR20030086279A (ko) | 2003-11-07 |
| JP4171656B2 (ja) | 2008-10-22 |
| EP1379508A2 (en) | 2004-01-14 |
| WO2002067865A2 (en) | 2002-09-06 |
| EP1379508A4 (en) | 2005-12-28 |
| EP1379508B1 (en) | 2010-09-01 |
| AU2002306604B2 (en) | 2007-09-13 |
| EP1379508B9 (en) | 2011-02-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60237512D1 (de) | N-(aryl)-2-arylethensulfonamide und ihre therapeutischen anwendungen | |
| SE0302811D0 (sv) | Novel compounds | |
| DE60314633D1 (de) | Substituierte 1,3-diphenylprop-2-en-1-on derivate, deren herstellung und anwendungen | |
| IS6658A (is) | Ný efnasambönd | |
| ATE455092T1 (de) | Substituierte tetracyclin-verbindungen zur behandlung von malaria | |
| TR200200768T2 (tr) | Yeni kuinüklidin türevleri ve bunu içeren ilaç bileşimleri | |
| SE0202133D0 (sv) | Novel compounds | |
| SE0104140D0 (sv) | Novel Compounds | |
| BR0113838A (pt) | Derivados de n-fenil-2-pirimidina-amina | |
| CY1110821T1 (el) | Antibakthpiakoi πapaγontες τρικυκλικης tετραϋδροκινολινης | |
| SE0101932D0 (sv) | Pharmaceutical combinations | |
| SE0201544D0 (sv) | Novel compounds and thier use | |
| SE0302139D0 (sv) | Novel compounds | |
| ATE413388T1 (de) | Muskarin antagonisten | |
| ECSP044999A (es) | Agentes antidiabeticos | |
| ATE236147T1 (de) | Derivate von flavonen, xanthonen und kumarinen | |
| DE60001586D1 (de) | Diphenyl-piperidin derivate | |
| PE20030061A1 (es) | 1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4 | |
| SE0101038D0 (sv) | Novel compounds | |
| DE69937301D1 (de) | Aminosterolderivate und ihre verwendungen | |
| SE0003476D0 (sv) | Compounds | |
| ATE497967T1 (de) | Interzelluläre kommunikation erleichternden verbindungen und deren medizinischen verwendungen | |
| SE0303280D0 (sv) | Novel compounds | |
| CY1105847T1 (el) | Γραμμικες βασικες ενωσεις που εμφανιζουν δραστικοτητα ανταγωνιστη της nk-2 και σκευασματα αυτων | |
| SE0302755D0 (sv) | Novel compounds |