CA2439255C - N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof - Google Patents
N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof Download PDFInfo
- Publication number
- CA2439255C CA2439255C CA2439255A CA2439255A CA2439255C CA 2439255 C CA2439255 C CA 2439255C CA 2439255 A CA2439255 A CA 2439255A CA 2439255 A CA2439255 A CA 2439255A CA 2439255 C CA2439255 C CA 2439255C
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- Prior art keywords
- unsubstituted
- alkyl
- substituted
- alkoxy
- aryl
- Prior art date
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- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Quinoline Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27198501P | 2001-02-28 | 2001-02-28 | |
| US60/271,985 | 2001-02-28 | ||
| PCT/US2002/005979 WO2002067865A2 (en) | 2001-02-28 | 2002-02-28 | N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2439255A1 CA2439255A1 (en) | 2002-09-06 |
| CA2439255C true CA2439255C (en) | 2011-01-04 |
Family
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Family Applications (1)
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|---|---|---|---|
| CA2439255A Expired - Fee Related CA2439255C (en) | 2001-02-28 | 2002-02-28 | N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof |
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| US (1) | US6646009B2 (enExample) |
| EP (1) | EP1379508B9 (enExample) |
| JP (1) | JP4171656B2 (enExample) |
| KR (1) | KR100850330B1 (enExample) |
| AT (1) | ATE479657T1 (enExample) |
| AU (1) | AU2002306604B2 (enExample) |
| CA (1) | CA2439255C (enExample) |
| DE (1) | DE60237512D1 (enExample) |
| DK (1) | DK1379508T3 (enExample) |
| IL (2) | IL157540A0 (enExample) |
| WO (1) | WO2002067865A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4302986B2 (ja) * | 2001-02-28 | 2009-07-29 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 細胞及び組織をα，β不飽和アリールスルホンにより電離放射線から防護する方法 |
| MXPA04008356A (es) * | 2002-02-28 | 2005-09-12 | Univ Temple | (e)-2,6-dialcoxiestiril bencilsulfonas sustituidas con un grupo amino y en la posicion 4 para tratar trastornos poliferativos. |
| IL163608A0 (en) * | 2002-02-28 | 2005-12-18 | Univ Temple | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders |
| US7744889B2 (en) * | 2003-11-14 | 2010-06-29 | Temple University - Of The Commonwealth System Of Higher Education | Alpha, beta-unsaturated sulfoxides for treating proliferative disorders |
| EP1740530B8 (en) * | 2004-03-16 | 2017-03-01 | Temple University - Of The Commonwealth System of Higher Education | Substituted phenoxy- and phenylthio-derivatives for treating proliferative disorders |
| WO2005090297A1 (en) * | 2004-03-19 | 2005-09-29 | Biotie Therapies Corporation | Sulphonamide derivatives |
| PL2035369T3 (pl) * | 2006-07-05 | 2015-02-27 | Fibrotech Therapeutics Pty Ltd | Związki terapeutyczne |
| JP5278968B2 (ja) | 2006-08-30 | 2013-09-04 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法 |
| CN107162928B (zh) * | 2007-12-21 | 2022-03-11 | 塞尔塔医疗有限公司 | 抗纤维化剂的卤代类似物 |
| WO2010144959A1 (en) * | 2009-06-18 | 2010-12-23 | Fibrotech Therapeutics Pty Ltd | Analogues of anti-fibrotic agents |
| CN102574843B (zh) | 2009-10-22 | 2015-06-17 | 法博太科制药有限公司 | 抗纤维化剂的稠环类似物 |
| WO2013039985A2 (en) * | 2011-09-12 | 2013-03-21 | The Johns Hopkins University | Serine protease inhibitors |
| WO2013056079A1 (en) * | 2011-10-13 | 2013-04-18 | The Johns Hopkins University | High affinity beta lactamase inhibitors |
| CN110776447A (zh) | 2012-09-20 | 2020-02-11 | 坦普尔大学 | 取代的烷基二芳基衍生物、制备方法和用途 |
| US10383831B2 (en) | 2015-08-03 | 2019-08-20 | Temple University—Of the Commonwealth System of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
| MX2019009235A (es) | 2017-02-03 | 2019-12-11 | Certa Therapeutics Pty Ltd | Compuestos antifibroticos. |
| JP2022517797A (ja) * | 2019-01-17 | 2022-03-10 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2531367A (en) * | 1947-07-15 | 1950-11-21 | Sharp & Dohme Inc | N-(substituted sulfonyl)-aminobenzoic acids |
| DE2118493C3 (de) | 1971-04-16 | 1980-04-30 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Aminostilbenen |
| US4035421A (en) | 1976-03-19 | 1977-07-12 | Morton-Norwich Products, Inc. | N-(3,4,-dichlorophenyl)-2-phenylethenesulfonamide |
| DE2809377A1 (de) * | 1978-03-04 | 1979-09-13 | Boehringer Mannheim Gmbh | Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| NZ238911A (en) | 1990-07-17 | 1993-10-26 | Lilly Co Eli | Furyl, pyrrolyl and thienyl sulphonyl urea derivatives, pharmaceutical compositions and intermediates therefor |
| JPH04202173A (ja) * | 1990-11-30 | 1992-07-22 | Zeria Pharmaceut Co Ltd | スルホンアミド誘導体及びそれを含有する５―リポキシゲナーゼ阻害剤 |
| WO1995024190A2 (en) * | 1994-03-07 | 1995-09-14 | Sugen, Inc. | Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof |
| EP0809492A4 (en) | 1995-02-17 | 2007-01-24 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
| US5780483A (en) * | 1995-02-17 | 1998-07-14 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| EA001367B1 (ru) | 1996-02-22 | 2001-02-26 | Туларик, Инк. | Пентафторбензолсульфонамиды и их аналоги |
| US6191170B1 (en) * | 1998-01-13 | 2001-02-20 | Tularik Inc. | Benzenesulfonamides and benzamides as therapeutic agents |
| NZ510435A (en) | 1998-09-23 | 2003-04-29 | Tularik Inc | Arylsulfonanilide ureas and pharmaceutical use |
| US6586617B1 (en) * | 1999-04-28 | 2003-07-01 | Sumitomo Chemical Takeda Agro Company, Limited | Sulfonamide derivatives |
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2002
- 2002-02-28 CA CA2439255A patent/CA2439255C/en not_active Expired - Fee Related
- 2002-02-28 DK DK02802229.1T patent/DK1379508T3/da active
- 2002-02-28 KR KR1020037011303A patent/KR100850330B1/ko not_active Expired - Fee Related
- 2002-02-28 US US10/085,826 patent/US6646009B2/en not_active Expired - Lifetime
- 2002-02-28 EP EP02802229A patent/EP1379508B9/en not_active Expired - Lifetime
- 2002-02-28 DE DE60237512T patent/DE60237512D1/de not_active Expired - Lifetime
- 2002-02-28 JP JP2002567237A patent/JP4171656B2/ja not_active Expired - Fee Related
- 2002-02-28 WO PCT/US2002/005979 patent/WO2002067865A2/en not_active Ceased
- 2002-02-28 IL IL15754002A patent/IL157540A0/xx unknown
- 2002-02-28 AT AT02802229T patent/ATE479657T1/de not_active IP Right Cessation
- 2002-02-28 AU AU2002306604A patent/AU2002306604B2/en not_active Ceased
-
2003
- 2003-08-21 IL IL157540A patent/IL157540A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002306604B2 (en) | 2007-09-13 |
| EP1379508A2 (en) | 2004-01-14 |
| KR20030086279A (ko) | 2003-11-07 |
| IL157540A0 (en) | 2004-03-28 |
| DK1379508T3 (da) | 2011-01-03 |
| EP1379508B9 (en) | 2011-02-09 |
| US20020165412A1 (en) | 2002-11-07 |
| WO2002067865A3 (en) | 2003-03-20 |
| WO2002067865A2 (en) | 2002-09-06 |
| KR100850330B1 (ko) | 2008-08-04 |
| JP2004530655A (ja) | 2004-10-07 |
| ATE479657T1 (de) | 2010-09-15 |
| JP4171656B2 (ja) | 2008-10-22 |
| DE60237512D1 (de) | 2010-10-14 |
| CA2439255A1 (en) | 2002-09-06 |
| IL157540A (en) | 2010-11-30 |
| EP1379508A4 (en) | 2005-12-28 |
| US6646009B2 (en) | 2003-11-11 |
| EP1379508B1 (en) | 2010-09-01 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20180228 |