DE60235794D1 - Konjugate von immunzellspezifischen makrolidverbindungen mit anti-phlogistischen verbindungen zur verbesserten zellgerichteten anti-phlogistischen therapie - Google Patents

Konjugate von immunzellspezifischen makrolidverbindungen mit anti-phlogistischen verbindungen zur verbesserten zellgerichteten anti-phlogistischen therapie

Info

Publication number
DE60235794D1
DE60235794D1 DE60235794T DE60235794T DE60235794D1 DE 60235794 D1 DE60235794 D1 DE 60235794D1 DE 60235794 T DE60235794 T DE 60235794T DE 60235794 T DE60235794 T DE 60235794T DE 60235794 D1 DE60235794 D1 DE 60235794D1
Authority
DE
Germany
Prior art keywords
phlogistic
compounds
immunetic
conjugates
therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60235794T
Other languages
English (en)
Inventor
Mladen Mercep
Milan Mesic
Linda Tomaskovic
Marijana Komac
Boska Hrvacic
Stribor Markovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidelta doo
Original Assignee
GlaxoSmithKline Istrazivacki Centar Zagreb doo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline Istrazivacki Centar Zagreb doo filed Critical GlaxoSmithKline Istrazivacki Centar Zagreb doo
Application granted granted Critical
Publication of DE60235794D1 publication Critical patent/DE60235794D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60235794T 2001-01-09 2002-01-03 Konjugate von immunzellspezifischen makrolidverbindungen mit anti-phlogistischen verbindungen zur verbesserten zellgerichteten anti-phlogistischen therapie Expired - Lifetime DE60235794D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR20010018A HRP20010018A2 (en) 2001-01-09 2001-01-09 Novel anti-inflammatory compounds
PCT/HR2002/000001 WO2002055531A1 (en) 2001-01-09 2002-01-03 Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy

Publications (1)

Publication Number Publication Date
DE60235794D1 true DE60235794D1 (de) 2010-05-12

Family

ID=10947235

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60235794T Expired - Lifetime DE60235794D1 (de) 2001-01-09 2002-01-03 Konjugate von immunzellspezifischen makrolidverbindungen mit anti-phlogistischen verbindungen zur verbesserten zellgerichteten anti-phlogistischen therapie

Country Status (24)

Country Link
US (2) US7446097B2 (de)
EP (1) EP1351973B1 (de)
JP (1) JP4474101B2 (de)
CN (1) CN1269836C (de)
AR (1) AR035727A1 (de)
AT (1) ATE462713T1 (de)
BG (1) BG108073A (de)
BR (1) BR0206347A (de)
CA (1) CA2434009C (de)
CZ (1) CZ20031825A3 (de)
DE (1) DE60235794D1 (de)
EA (1) EA007061B1 (de)
EE (1) EE05333B1 (de)
ES (1) ES2342364T3 (de)
GE (1) GEP20053607B (de)
HK (1) HK1065320A1 (de)
HR (1) HRP20010018A2 (de)
HU (1) HUP0500180A3 (de)
IL (1) IL156673A0 (de)
PL (1) PL207636B1 (de)
RS (1) RS51308B (de)
SK (1) SK9792003A3 (de)
UA (1) UA77166C2 (de)
WO (1) WO2002055531A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002109169A (ja) * 2000-09-29 2002-04-12 Hitachi Ltd 作業支援方法並びにシステム及び作業支援方法を記録した記録媒体
AU2003219770B2 (en) * 2002-02-15 2008-10-09 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US7271154B2 (en) 2002-02-15 2007-09-18 Merckle Gmbh Antibiotic conjugates
WO2003070173A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
CN100577681C (zh) * 2002-07-08 2010-01-06 葛兰素伊斯特拉齐瓦基森塔萨格勒布公司 用于治疗炎性疾病和病症的新化合物、组合物和方法
JP2005536488A (ja) * 2002-07-08 2005-12-02 プリヴァ−イストラジヴァキ・インスティトゥ・ディー・オー・オー 新規な非ステロイド抗炎症物質、組成物、およびその使用方法
ATE429441T1 (de) * 2002-07-08 2009-05-15 Glaxosmithkline Zagreb Hybridmoleküle von makroliden mit steroidalen/nicht-steroidalen antientzündlich aktiven molekülen
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
JP4737495B2 (ja) * 2004-01-14 2011-08-03 塩野義製薬株式会社 エリスロマイシン誘導体
US20060183696A1 (en) * 2004-08-12 2006-08-17 Pliva-Istrazivacki Institut D.O.O. Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract
US20060035845A1 (en) * 2004-08-12 2006-02-16 Pliva-Istrazivacki Institut D.O.O. Use of immune cell specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
CA2585711A1 (en) 2004-10-27 2006-05-04 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugates with anti-inflammatory activity
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
US20080249034A1 (en) * 2005-03-21 2008-10-09 Zambon S.P.A. Use of Macrolides for Treating Intestinal Inflammation
WO2011116312A1 (en) * 2010-03-19 2011-09-22 Catabasis Pharmaceuticals, Inc. Fatty acid macrolide derivatives and their uses
EP3795578A3 (de) 2014-07-23 2021-05-26 Sphaera Pharma Pvt. Ltd. Hydroxysteroidverbindungen, deren zwischenprodukte, verfahren zur herstellung, zusammensetzung und verwendungen davon
GB201520419D0 (en) * 2015-11-19 2016-01-06 Epi Endo Pharmaceuticals Ehf Compounds
WO2023248010A2 (en) * 2022-06-23 2023-12-28 Synovo Gmbh Targeted modulators of jak3 for treatment of inflammatory and autoimmune diseases

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4710495A (en) * 1980-07-10 1987-12-01 Otsuka Pharmaceutical Co., Ltd. Soft steroids having anti-inflammatory activity
EP0283055B1 (de) 1987-09-03 1990-08-29 SOUR PLIVA farmaceutska, Kemijska prehrambena i kozmeticka industrija, n.sol.o. 10-Dihydro-10-deoxo-11-azaerythronolid-A-Verbindungen,Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung in Arzneimitteln und in deren Herstellung
JPH01163124A (ja) 1987-12-21 1989-06-27 Yamayuu Seikatsushiya:Kk 外用鎮痛消炎消腫消膿剤
SE9100342D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
SE9100341D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroids
GB9225923D0 (en) 1992-12-11 1993-02-03 Rhone Poulenc Rorer Ltd New compositions of matter
HUT72442A (en) 1992-12-24 1996-04-29 Rhone Poulenc Rorer Ltd Steroids condensed with heteroring containing oxygene, pharmaceutical compositions containing them and processes for their production
EP0771564A4 (de) 1994-08-12 1998-05-06 Taisho Pharmaceutical Co Ltd Inhibitor der interleukin-5-produktion
WO1996004920A1 (fr) 1994-08-12 1996-02-22 Taisho Pharmaceutical Co., Ltd. Inhibiteur de production de l'interleukine-5
DE19542949A1 (de) 1995-11-17 1997-07-17 Hilti Ag Bolzen zum Eintreiben in harte Aufnahmewerkstoffe
US5928868A (en) * 1996-04-26 1999-07-27 Massachusetts Institute Of Technology Three hybrid screening assay
FR2776927B1 (fr) 1998-04-07 2002-07-05 Univ Paris Curie Compositions pour la vectorisation de molecules
WO1999064040A1 (en) * 1998-06-08 1999-12-16 Advanced Medicine, Inc. Novel polyene macrolide compounds and uses
EP1085846A2 (de) * 1998-06-08 2001-03-28 Advanced Medicine, Inc. Mehrfachbindende inhibitoren des microsomalen triglyceridtransferase-proteins
IT1306205B1 (it) 1999-01-15 2001-05-30 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
AU2003219770B2 (en) 2002-02-15 2008-10-09 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof

Also Published As

Publication number Publication date
HUP0500180A2 (en) 2006-09-28
US7446097B2 (en) 2008-11-04
PL207636B1 (pl) 2011-01-31
EE05333B1 (et) 2010-08-16
JP2004518670A (ja) 2004-06-24
WO2002055531A1 (en) 2002-07-18
HK1065320A1 (en) 2005-02-18
ATE462713T1 (de) 2010-04-15
US20090105163A1 (en) 2009-04-23
ES2342364T3 (es) 2010-07-06
EP1351973B1 (de) 2010-03-31
US20040198677A1 (en) 2004-10-07
PL363478A1 (en) 2004-11-15
BR0206347A (pt) 2004-02-10
EA007061B1 (ru) 2006-06-30
HUP0500180A3 (en) 2009-12-28
HRP20010018A2 (en) 2002-12-31
EP1351973A1 (de) 2003-10-15
IL156673A0 (en) 2004-01-04
EA200300781A1 (ru) 2003-12-25
SK9792003A3 (en) 2004-01-08
CA2434009C (en) 2009-09-29
GEP20053607B (en) 2005-09-12
CA2434009A1 (en) 2002-07-18
CN1269836C (zh) 2006-08-16
CN1491230A (zh) 2004-04-21
YU55203A (sh) 2006-03-03
UA77166C2 (en) 2006-11-15
CZ20031825A3 (cs) 2003-11-12
RS51308B (sr) 2010-12-31
EE200300293A (et) 2003-10-15
BG108073A (bg) 2005-05-31
JP4474101B2 (ja) 2010-06-02
AR035727A1 (es) 2004-07-07
US7928078B2 (en) 2011-04-19

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