DE60234542D1 - Polyamin-retinoid konjugate und deren herstellung - Google Patents

Polyamin-retinoid konjugate und deren herstellung

Info

Publication number
DE60234542D1
DE60234542D1 DE60234542T DE60234542T DE60234542D1 DE 60234542 D1 DE60234542 D1 DE 60234542D1 DE 60234542 T DE60234542 T DE 60234542T DE 60234542 T DE60234542 T DE 60234542T DE 60234542 D1 DE60234542 D1 DE 60234542D1
Authority
DE
Germany
Prior art keywords
polyamine
preparation
gamma
retinoid conjugates
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60234542T
Other languages
English (en)
Inventor
Dionysios Papaioannou
Dionysios Drainas
Life Sciences S A Ha Biomedica
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE60234542D1 publication Critical patent/DE60234542D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/547Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE60234542T 2002-08-22 2002-08-22 Polyamin-retinoid konjugate und deren herstellung Expired - Lifetime DE60234542D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GR2002/000045 WO2004018001A1 (en) 2002-08-22 2002-08-22 Polyamine conjugates with acidic retinoids and preparation thereof

Publications (1)

Publication Number Publication Date
DE60234542D1 true DE60234542D1 (de) 2010-01-07

Family

ID=31898327

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60234542T Expired - Lifetime DE60234542D1 (de) 2002-08-22 2002-08-22 Polyamin-retinoid konjugate und deren herstellung

Country Status (10)

Country Link
US (1) US7517913B2 (de)
EP (1) EP1569694B1 (de)
AT (1) ATE449613T1 (de)
AU (1) AU2002324242A1 (de)
CY (1) CY1110285T1 (de)
DE (1) DE60234542D1 (de)
DK (1) DK1569694T3 (de)
ES (1) ES2336772T3 (de)
PT (1) PT1569694E (de)
WO (1) WO2004018001A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517913B2 (en) 2002-08-22 2009-04-14 Dionysios Papaioannou Polyamine conjugates with acidic retinoids and preparation thereof
US9072778B2 (en) 2005-12-20 2015-07-07 University Of Hawaii Treatment regimen for N-MYC, c-MYC, and L-MYC amplified and overexpressed tumors
US20080312174A1 (en) * 2007-06-05 2008-12-18 Nitto Denko Corporation Water soluble crosslinked polymers
EP2207570A2 (de) * 2007-09-14 2010-07-21 Nitto Denko Corporation Arzneimittelträger
US20100221328A1 (en) * 2008-12-31 2010-09-02 Wertz Christian F Sustained-release formulations
DE102011080131A1 (de) 2011-07-29 2013-01-31 Evonik Degussa Gmbh Niedermolekulare Produkte, und deren Verwendung als reversible oder permanente Niedertemperatur-Vernetzer bei Diels-Alder-Reaktionen
CN102603555B (zh) * 2012-03-22 2014-04-16 浙江大学 一种全反式维甲酸酰胺衍生物及其制备方法和应用
JP2015221830A (ja) * 2015-08-26 2015-12-10 チョンシー ユー 非常に高い皮膚浸透率を有するレチノイド及びレチノイド様化合物の正に荷電した水溶性プロドラッグ
GR1009980B (el) 2020-03-10 2021-04-22 Πανεπιστημιο Πατρων Κρυσταλλικες μορφες αλατων της ν1-ν12-δι(all-trans-ρετινοϋλο)σπερμινης, διεργασιες για την παραγωγη τους, και φαρμακευτικες συνθεσεις αυτων

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9702310D0 (en) 1997-02-05 1997-03-26 Univ Hertfordshire Invention
FR2763853B1 (fr) * 1997-05-28 2000-01-07 Oreal Association d'un retinoide avec un polymere polyamine
US7517913B2 (en) 2002-08-22 2009-04-14 Dionysios Papaioannou Polyamine conjugates with acidic retinoids and preparation thereof

Also Published As

Publication number Publication date
EP1569694B1 (de) 2009-11-25
AU2002324242A1 (en) 2004-03-11
US7517913B2 (en) 2009-04-14
US20060189696A1 (en) 2006-08-24
ATE449613T1 (de) 2009-12-15
DK1569694T3 (da) 2010-03-29
ES2336772T3 (es) 2010-04-16
WO2004018001A1 (en) 2004-03-04
CY1110285T1 (el) 2015-01-14
EP1569694A1 (de) 2005-09-07
PT1569694E (pt) 2010-02-23

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