CY1110285T1 - Συζευγματα πολυαμινων με οξινα ρετινοειδη και παρασκευες τους - Google Patents
Συζευγματα πολυαμινων με οξινα ρετινοειδη και παρασκευες τουςInfo
- Publication number
- CY1110285T1 CY1110285T1 CY20101100060T CY101100060T CY1110285T1 CY 1110285 T1 CY1110285 T1 CY 1110285T1 CY 20101100060 T CY20101100060 T CY 20101100060T CY 101100060 T CY101100060 T CY 101100060T CY 1110285 T1 CY1110285 T1 CY 1110285T1
- Authority
- CY
- Cyprus
- Prior art keywords
- conjugates
- polyamines
- preparations
- gamma
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Έχουν εφευρεθεί πρωτότυπα συζεύγματα πολυαμινών τα οποία αποκτήθηκαν εύκολα χρησιμοποιώντας ως στάδιο-κλειδί τη συμπύκνωση γραμμικών, διαμορφωτικώς περιορισμένων, κυκλικών και διακλαδισμένων πολυαμινών ή κατάλληλα προστατευμένων παραγώγων τους με παράγωγα της βιταμίνης Α. Αυτές οι ενώσεις αναστέλλουν το ριβοένζυμο ριβονουκλεάση Ρ (RNase Ρ) καθώς και τη παραγωγή ιντερλευκίνης-2 (IL-2) και ιντερφερόνης-γ (IFN-γ) από περιφερικά μονοπύρηνα κύτταρα του αίματος in vitro.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02758661A EP1569694B1 (en) | 2002-08-22 | 2002-08-22 | Polyamine conjugates with acidic retinoids and preparation thereof |
PCT/GR2002/000045 WO2004018001A1 (en) | 2002-08-22 | 2002-08-22 | Polyamine conjugates with acidic retinoids and preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110285T1 true CY1110285T1 (el) | 2015-01-14 |
Family
ID=31898327
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100060T CY1110285T1 (el) | 2002-08-22 | 2010-01-20 | Συζευγματα πολυαμινων με οξινα ρετινοειδη και παρασκευες τους |
Country Status (10)
Country | Link |
---|---|
US (1) | US7517913B2 (el) |
EP (1) | EP1569694B1 (el) |
AT (1) | ATE449613T1 (el) |
AU (1) | AU2002324242A1 (el) |
CY (1) | CY1110285T1 (el) |
DE (1) | DE60234542D1 (el) |
DK (1) | DK1569694T3 (el) |
ES (1) | ES2336772T3 (el) |
PT (1) | PT1569694E (el) |
WO (1) | WO2004018001A1 (el) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004018001A1 (en) | 2002-08-22 | 2004-03-04 | Dionysios Papaioannou | Polyamine conjugates with acidic retinoids and preparation thereof |
US9072778B2 (en) | 2005-12-20 | 2015-07-07 | University Of Hawaii | Treatment regimen for N-MYC, c-MYC, and L-MYC amplified and overexpressed tumors |
US20080312174A1 (en) * | 2007-06-05 | 2008-12-18 | Nitto Denko Corporation | Water soluble crosslinked polymers |
CA2698812A1 (en) * | 2007-09-14 | 2009-03-19 | Nitto Denko Corporation | Drug carriers |
US20100221328A1 (en) * | 2008-12-31 | 2010-09-02 | Wertz Christian F | Sustained-release formulations |
DE102011080131A1 (de) | 2011-07-29 | 2013-01-31 | Evonik Degussa Gmbh | Niedermolekulare Produkte, und deren Verwendung als reversible oder permanente Niedertemperatur-Vernetzer bei Diels-Alder-Reaktionen |
CN102603555B (zh) * | 2012-03-22 | 2014-04-16 | 浙江大学 | 一种全反式维甲酸酰胺衍生物及其制备方法和应用 |
JP2015221830A (ja) * | 2015-08-26 | 2015-12-10 | チョンシー ユー | 非常に高い皮膚浸透率を有するレチノイド及びレチノイド様化合物の正に荷電した水溶性プロドラッグ |
GR1009980B (el) * | 2020-03-10 | 2021-04-22 | Πανεπιστημιο Πατρων | Κρυσταλλικες μορφες αλατων της ν1-ν12-δι(all-trans-ρετινοϋλο)σπερμινης, διεργασιες για την παραγωγη τους, και φαρμακευτικες συνθεσεις αυτων |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9702310D0 (en) * | 1997-02-05 | 1997-03-26 | Univ Hertfordshire | Invention |
FR2763853B1 (fr) * | 1997-05-28 | 2000-01-07 | Oreal | Association d'un retinoide avec un polymere polyamine |
WO2004018001A1 (en) | 2002-08-22 | 2004-03-04 | Dionysios Papaioannou | Polyamine conjugates with acidic retinoids and preparation thereof |
-
2002
- 2002-08-22 WO PCT/GR2002/000045 patent/WO2004018001A1/en not_active Application Discontinuation
- 2002-08-22 US US10/549,905 patent/US7517913B2/en not_active Expired - Fee Related
- 2002-08-22 AT AT02758661T patent/ATE449613T1/de active
- 2002-08-22 AU AU2002324242A patent/AU2002324242A1/en not_active Abandoned
- 2002-08-22 DE DE60234542T patent/DE60234542D1/de not_active Expired - Lifetime
- 2002-08-22 ES ES02758661T patent/ES2336772T3/es not_active Expired - Lifetime
- 2002-08-22 EP EP02758661A patent/EP1569694B1/en not_active Expired - Lifetime
- 2002-08-22 PT PT02758661T patent/PT1569694E/pt unknown
- 2002-08-22 DK DK02758661.9T patent/DK1569694T3/da active
-
2010
- 2010-01-20 CY CY20101100060T patent/CY1110285T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK1569694T3 (da) | 2010-03-29 |
ATE449613T1 (de) | 2009-12-15 |
PT1569694E (pt) | 2010-02-23 |
US20060189696A1 (en) | 2006-08-24 |
EP1569694B1 (en) | 2009-11-25 |
WO2004018001A1 (en) | 2004-03-04 |
ES2336772T3 (es) | 2010-04-16 |
EP1569694A1 (en) | 2005-09-07 |
AU2002324242A1 (en) | 2004-03-11 |
US7517913B2 (en) | 2009-04-14 |
DE60234542D1 (de) | 2010-01-07 |
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