DE60233477D1 - Mobilitätsmodifizierte nukleobasenpolymere und verfahren zu deren verwendung - Google Patents
Mobilitätsmodifizierte nukleobasenpolymere und verfahren zu deren verwendungInfo
- Publication number
- DE60233477D1 DE60233477D1 DE60233477T DE60233477T DE60233477D1 DE 60233477 D1 DE60233477 D1 DE 60233477D1 DE 60233477 T DE60233477 T DE 60233477T DE 60233477 T DE60233477 T DE 60233477T DE 60233477 D1 DE60233477 D1 DE 60233477D1
- Authority
- DE
- Germany
- Prior art keywords
- mobility
- polymers
- oligonucleobase
- modifying
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920000642 polymer Polymers 0.000 title abstract 9
- 239000003153 chemical reaction reagent Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 150000008300 phosphoramidites Chemical class 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 238000005251 capillar electrophoresis Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- -1 phosphate triester Chemical class 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Polyethers (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/836,704 US6743905B2 (en) | 2001-04-16 | 2001-04-16 | Mobility-modified nucleobase polymers and methods of using same |
| PCT/US2002/011824 WO2002083954A1 (en) | 2001-04-16 | 2002-04-15 | Mobility-modified nucleobase polymers and methods of using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60233477D1 true DE60233477D1 (de) | 2009-10-08 |
Family
ID=25272541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60233477T Expired - Lifetime DE60233477D1 (de) | 2001-04-16 | 2002-04-15 | Mobilitätsmodifizierte nukleobasenpolymere und verfahren zu deren verwendung |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US6743905B2 (https=) |
| EP (1) | EP1379698B1 (https=) |
| JP (2) | JP4452445B2 (https=) |
| AT (1) | ATE440966T1 (https=) |
| CA (1) | CA2443122A1 (https=) |
| DE (1) | DE60233477D1 (https=) |
| WO (1) | WO2002083954A1 (https=) |
Families Citing this family (92)
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| US20030207300A1 (en) * | 2000-04-28 | 2003-11-06 | Matray Tracy J. | Multiplex analytical platform using molecular tags |
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| US6743905B2 (en) * | 2001-04-16 | 2004-06-01 | Applera Corporation | Mobility-modified nucleobase polymers and methods of using same |
| PL373962A1 (en) | 2001-05-21 | 2005-09-19 | Aclara Biosciences, Inc. | Methods and compositions for analyzing proteins |
| WO2005005666A1 (en) * | 2002-11-19 | 2005-01-20 | Singulex, Inc. | Detection of target molecules through interaction with probes |
| US20040126765A1 (en) * | 2002-12-27 | 2004-07-01 | Adams Craig W. | Method and compositions for sequencing nucleic acid molecules |
| WO2005001129A2 (en) * | 2003-06-06 | 2005-01-06 | Applera Corporation | Mobility cassettes |
| EP1704245A1 (en) * | 2003-12-31 | 2006-09-27 | Applera Corporation | Multiplex protease profiling |
| US20080103053A1 (en) * | 2005-11-22 | 2008-05-01 | Helicos Biosciences Corporation | Methods and compositions for sequencing a nucleic acid |
| JP5503148B2 (ja) * | 2006-02-22 | 2014-05-28 | コヴィディエン リミテッド パートナーシップ | 生分解性リン酸エステルポリアミン |
| WO2007106690A2 (en) * | 2006-03-15 | 2007-09-20 | Siemens Healthcare Diagnostics Inc. | Degenerate nucleobase analogs |
| AU2007268075C1 (en) * | 2006-06-01 | 2013-03-07 | Trilink Biotechnologies | Chemically modified oligonucleotide primers for nucleic acid amplification |
| EP3543357A1 (en) | 2007-05-08 | 2019-09-25 | Trustees of Boston University | Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof |
| US8097712B2 (en) | 2007-11-07 | 2012-01-17 | Beelogics Inc. | Compositions for conferring tolerance to viral disease in social insects, and the use thereof |
| WO2010046829A1 (en) * | 2008-10-20 | 2010-04-29 | Koninklijke Philips Electronics N.V. | Separation free ser(r)s assay |
| WO2011027966A2 (en) * | 2009-09-03 | 2011-03-10 | Seegene, Inc. | Td probe and its uses |
| AU2010301128B2 (en) | 2009-09-30 | 2014-09-18 | Quantapore, Inc. | Ultrafast sequencing of biological polymers using a labeled nanopore |
| US8962584B2 (en) | 2009-10-14 | 2015-02-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Compositions for controlling Varroa mites in bees |
| ES2641642T3 (es) | 2010-03-08 | 2017-11-10 | Monsanto Technology Llc | Moléculas de polinucleótido para regulación génica en plantas |
| CA2821411C (en) | 2010-12-13 | 2020-02-25 | Quiapeg Pharmaceuticals Ab | Functionalized polymers |
| MX348495B (es) | 2011-09-13 | 2017-06-14 | Monsanto Technology Llc | Metodos y composiciones para el control de malezas. |
| CN103930549B (zh) | 2011-09-13 | 2020-09-18 | 孟山都技术公司 | 用于杂草控制的方法和组合物 |
| US10760086B2 (en) | 2011-09-13 | 2020-09-01 | Monsanto Technology Llc | Methods and compositions for weed control |
| EP3382027A3 (en) | 2011-09-13 | 2018-10-31 | Monsanto Technology LLC | Methods and compositions for weed control |
| EP2756084B1 (en) | 2011-09-13 | 2020-06-03 | Monsanto Technology LLC | Methods and compositions for weed control |
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| MX361938B (es) | 2011-09-13 | 2018-12-19 | Monsanto Technology Llc | Métodos y composiciones para el control de malezas. |
| US9840715B1 (en) | 2011-09-13 | 2017-12-12 | Monsanto Technology Llc | Methods and compositions for delaying senescence and improving disease tolerance and yield in plants |
| US9920326B1 (en) | 2011-09-14 | 2018-03-20 | Monsanto Technology Llc | Methods and compositions for increasing invertase activity in plants |
| WO2013126034A1 (en) * | 2012-02-22 | 2013-08-29 | Chemgenes Corporation | Synthesis of high purity dmt-c3-disulfide phosphoramidite |
| MX360866B (es) | 2012-05-24 | 2018-11-09 | A B Seeds Ltd | Composiciones y métodos para silenciar la expresión genética. |
| CA3114356C (en) | 2012-06-12 | 2023-08-22 | Quiapeg Pharmaceuticals Ab | Conjugates of biologically active molecules to functionalized polymers |
| EP3418395A1 (en) | 2012-09-06 | 2018-12-26 | Life Technologies Corporation | Multiplex y-str analysis |
| ES2763413T3 (es) | 2012-09-24 | 2020-05-28 | Seminis Vegetable Seeds Inc | Procedimientos y composiciones para prolongar la vida útil de productos vegetales |
| CA2888264A1 (en) | 2012-10-18 | 2014-04-24 | Monsanto Technology Llc | Methods and compositions for plant pest control |
| US9651539B2 (en) | 2012-10-28 | 2017-05-16 | Quantapore, Inc. | Reducing background fluorescence in MEMS materials by low energy ion beam treatment |
| UY35252A (es) | 2013-01-01 | 2014-07-31 | Seeds Ltd Ab | MÉTODOS PARA INTRODUCIR dsRNA EN SEMILLAS DE PLANTAS PARA MODULAR LA EXPRESIÓN GENÉTICA |
| US10683505B2 (en) | 2013-01-01 | 2020-06-16 | Monsanto Technology Llc | Methods of introducing dsRNA to plant seeds for modulating gene expression |
| EP2945484A4 (en) | 2013-01-15 | 2017-03-29 | Monsanto Technology LLC | Methods and compositions for plant pest control |
| US10000767B2 (en) | 2013-01-28 | 2018-06-19 | Monsanto Technology Llc | Methods and compositions for plant pest control |
| BR112015023051A2 (pt) | 2013-03-13 | 2017-11-14 | Monsanto Technology Llc | método para controle de ervas daninhas, composição herbicida, cassete de expressão microbiano e método de produção de polinucleotídeo |
| US10612019B2 (en) | 2013-03-13 | 2020-04-07 | Monsanto Technology Llc | Methods and compositions for weed control |
| US20140283211A1 (en) | 2013-03-14 | 2014-09-18 | Monsanto Technology Llc | Methods and Compositions for Plant Pest Control |
| US10568328B2 (en) | 2013-03-15 | 2020-02-25 | Monsanto Technology Llc | Methods and compositions for weed control |
| WO2014190322A2 (en) | 2013-05-24 | 2014-11-27 | Quantapore, Inc. | Nanopore-based nucleic acid analysis with mixed fret detection |
| US9850496B2 (en) | 2013-07-19 | 2017-12-26 | Monsanto Technology Llc | Compositions and methods for controlling Leptinotarsa |
| EP3030663B1 (en) | 2013-07-19 | 2019-09-04 | Monsanto Technology LLC | Compositions and methods for controlling leptinotarsa |
| EP3019559A4 (en) | 2013-08-22 | 2017-04-05 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| AU2014341879B2 (en) | 2013-11-04 | 2020-07-23 | Greenlight Biosciences, Inc. | Compositions and methods for controlling arthropod parasite and pest infestations |
| UA119253C2 (uk) | 2013-12-10 | 2019-05-27 | Біолоджикс, Інк. | Спосіб боротьби із вірусом у кліща varroa та у бджіл |
| WO2015108982A2 (en) | 2014-01-15 | 2015-07-23 | Monsanto Technology Llc | Methods and compositions for weed control using epsps polynucleotides |
| WO2015153339A2 (en) | 2014-04-01 | 2015-10-08 | Monsanto Technology Llc | Compositions and methods for controlling insect pests |
| CN106795515B (zh) | 2014-06-23 | 2021-06-08 | 孟山都技术公司 | 用于经由rna干扰调控基因表达的组合物和方法 |
| US11807857B2 (en) | 2014-06-25 | 2023-11-07 | Monsanto Technology Llc | Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression |
| CN106604993A (zh) | 2014-07-29 | 2017-04-26 | 孟山都技术公司 | 用于控制昆虫害虫的组合物和方法 |
| ES2789000T3 (es) | 2014-10-10 | 2020-10-23 | Quantapore Inc | Análisis de polinucleótidos basado en nanoporos con marcadores fluorescentes que se inactivan mutuamente |
| US9624537B2 (en) | 2014-10-24 | 2017-04-18 | Quantapore, Inc. | Efficient optical analysis of polymers using arrays of nanostructures |
| CN108064288B (zh) | 2015-01-22 | 2021-11-26 | 孟山都技术公司 | 用于控制叶甲属的组合物和方法 |
| JP6806694B2 (ja) | 2015-02-26 | 2021-01-06 | ソニー株式会社 | 共役基を含む水溶性蛍光染料または有色染料 |
| EP3302053B1 (en) | 2015-06-02 | 2021-03-17 | Monsanto Technology LLC | Compositions and methods for delivery of a polynucleotide into a plant |
| WO2016196782A1 (en) | 2015-06-03 | 2016-12-08 | Monsanto Technology Llc | Methods and compositions for introducing nucleic acids into plants |
| WO2017132330A1 (en) | 2016-01-26 | 2017-08-03 | Monsanto Technology Llc | Compositions and methods for controlling insect pests |
| AU2017240154B2 (en) | 2016-04-01 | 2021-08-12 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
| US9851359B2 (en) | 2016-04-06 | 2017-12-26 | Sony Corporation Of America | Ultra bright dimeric or polymeric dyes with spacing linker groups |
| KR102526802B1 (ko) | 2016-05-11 | 2023-05-02 | 소니그룹주식회사 | 초고명도 이량체성 또는 중합체성 염료 |
| US10823721B2 (en) | 2016-07-05 | 2020-11-03 | Quantapore, Inc. | Optically based nanopore sequencing |
| US10822647B2 (en) | 2016-07-12 | 2020-11-03 | Biodynamics S.R.L. | Methods for using long ssDNA polynucleotides as primers (superprimers) in PCR assays |
| US10465242B2 (en) | 2016-07-14 | 2019-11-05 | University Of Utah Research Foundation | Multi-sequence capture system |
| JP7312929B2 (ja) | 2016-07-29 | 2023-07-24 | ソニーグループ株式会社 | 超明色二量体またはポリマー色素およびその調製のための方法 |
| EP4011396A1 (en) | 2017-03-10 | 2022-06-15 | QuiaPEG Pharmaceuticals AB | Releasable conjugates |
| CN111093711A (zh) | 2017-10-05 | 2020-05-01 | 索尼公司 | 可编程的树枝状药物 |
| JP7551056B2 (ja) | 2017-10-05 | 2024-09-17 | ソニーグループ株式会社 | プログラマブルなポリマー薬物 |
| CN111836645A (zh) | 2017-11-16 | 2020-10-27 | 索尼公司 | 可编程的聚合药物 |
| US12194104B2 (en) | 2018-01-12 | 2025-01-14 | Sony Group Corporation | Phosphoalkyl ribose polymers comprising biologically active compounds |
| CN111565756A (zh) | 2018-01-12 | 2020-08-21 | 索尼公司 | 包含生物活性化合物的具有刚性间隔基团的聚合物 |
| EP3737419B1 (en) | 2018-01-12 | 2024-04-10 | Sony Group Corporation | Phosphoalkyl polymers comprising biologically active compounds |
| US11874280B2 (en) | 2018-03-19 | 2024-01-16 | Sony Group Corporation | Use of divalent metals for enhancement of fluorescent signals |
| KR102864292B1 (ko) | 2018-03-21 | 2025-09-26 | 소니그룹주식회사 | 링커 군을 갖는 중합체성 텐덤 염료 |
| US12006438B2 (en) | 2018-06-27 | 2024-06-11 | Sony Group Corporation | Polymeric dyes with linker groups comprising deoxyribose |
| EP3820944A1 (en) | 2018-07-13 | 2021-05-19 | Sony Corporation | Polymeric dyes having a backbone comprising organophosphate units |
| AU2019340472A1 (en) | 2018-09-12 | 2021-04-01 | Quiapeg Pharmaceuticals Ab | Releasable GLP-1 conjugates |
| WO2021062176A2 (en) | 2019-09-26 | 2021-04-01 | Sony Corporation | Polymeric tandem dyes with linker groups |
| EP4038081A1 (en) | 2019-09-30 | 2022-08-10 | Sony Group Corporation | Nucleotide probes |
| JP2023532494A (ja) * | 2020-06-30 | 2023-07-28 | イルミナ インコーポレイテッド | 少なくとも電気特性を使用した配列決定のための構成物及び方法 |
| EP4251764A1 (en) * | 2020-11-25 | 2023-10-04 | Sony Group Corporation | Polymer dyes |
| WO2022125564A1 (en) * | 2020-12-07 | 2022-06-16 | Sony Group Corporation | Spacing linker group design for brightness enhancement in dimeric or polymeric dyes |
| KR20220087091A (ko) * | 2020-12-17 | 2022-06-24 | 오토텔릭바이오 주식회사 | 고순도 안티센스 올리고뉴클레오타이드의 제조방법 |
| EP4074839A1 (en) * | 2021-04-16 | 2022-10-19 | Biotype GmbH | Optimized oligonucleotide tx probe for a multiplexing analysis of nucleic acids and a multiplexing method |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1218721B (de) * | 1960-07-20 | 1966-06-08 | Bayer Ag | Stabilisieren chlorhaltiger Polymerisate |
| NL261632A (https=) * | 1960-02-26 | |||
| US5470974A (en) | 1985-03-15 | 1995-11-28 | Neu-Gene Development Group | Uncharged polynucleotide-binding polymers |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US4914210A (en) | 1987-10-02 | 1990-04-03 | Cetus Corporation | Oligonucleotide functionalizing reagents |
| US5470967A (en) | 1990-04-10 | 1995-11-28 | The Dupont Merck Pharmaceutical Company | Oligonucleotide analogs with sulfamate linkages |
| US5470705A (en) * | 1992-04-03 | 1995-11-28 | Applied Biosystems, Inc. | Probe composition containing a binding domain and polymer chain and methods of use |
| ATE173767T1 (de) | 1992-04-03 | 1998-12-15 | Perkin Elmer Corp | Proben zusammensetzung und verfahren |
| US5696253A (en) | 1994-06-30 | 1997-12-09 | The Regents Of The University Of California | Polynucleoside chain with 3'→5' guanidyl linkages |
| EP0840741B1 (en) | 1995-06-07 | 2004-04-28 | Perseptive Biosystems, Inc. | Pna-dna chimeras and pna synthons for their preparation |
| NZ336539A (en) | 1996-10-15 | 2000-09-29 | Liposome Co Inc | Peptide-lipid conjugates, liposomes and liposomal drug delivery |
| US6339069B1 (en) | 1996-10-15 | 2002-01-15 | Elan Pharmaceuticalstechnologies, Inc. | Peptide-lipid conjugates, liposomes and lipsomal drug delivery |
| US6395486B1 (en) * | 1999-03-15 | 2002-05-28 | Applera Corporation | Probe/mobility modifier complexes for multiplexnucleic acid detection |
| US6743905B2 (en) | 2001-04-16 | 2004-06-01 | Applera Corporation | Mobility-modified nucleobase polymers and methods of using same |
-
2001
- 2001-04-16 US US09/836,704 patent/US6743905B2/en not_active Expired - Lifetime
-
2002
- 2002-04-15 EP EP02731376A patent/EP1379698B1/en not_active Expired - Lifetime
- 2002-04-15 JP JP2002581694A patent/JP4452445B2/ja not_active Expired - Fee Related
- 2002-04-15 AT AT02731376T patent/ATE440966T1/de not_active IP Right Cessation
- 2002-04-15 DE DE60233477T patent/DE60233477D1/de not_active Expired - Lifetime
- 2002-04-15 WO PCT/US2002/011824 patent/WO2002083954A1/en not_active Ceased
- 2002-04-15 CA CA002443122A patent/CA2443122A1/en not_active Abandoned
-
2004
- 2004-05-28 US US10/856,752 patent/US7074569B2/en not_active Expired - Lifetime
-
2006
- 2006-07-11 US US11/456,836 patent/US7897338B2/en not_active Expired - Fee Related
-
2009
- 2009-07-29 JP JP2009177108A patent/JP2009240332A/ja not_active Withdrawn
-
2011
- 2011-01-19 US US13/009,827 patent/US20110160082A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE440966T1 (de) | 2009-09-15 |
| EP1379698A4 (en) | 2007-04-25 |
| EP1379698A1 (en) | 2004-01-14 |
| EP1379698B1 (en) | 2009-08-26 |
| JP2009240332A (ja) | 2009-10-22 |
| US20020182602A1 (en) | 2002-12-05 |
| US7074569B2 (en) | 2006-07-11 |
| JP4452445B2 (ja) | 2010-04-21 |
| US7897338B2 (en) | 2011-03-01 |
| US20070026434A1 (en) | 2007-02-01 |
| JP2004535382A (ja) | 2004-11-25 |
| US20110160082A1 (en) | 2011-06-30 |
| US20050042644A1 (en) | 2005-02-24 |
| WO2002083954A1 (en) | 2002-10-24 |
| US6743905B2 (en) | 2004-06-01 |
| CA2443122A1 (en) | 2002-10-24 |
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