DE60231057D1 - Chemokine mutanten, die als chemokine antagonisten wirken - Google Patents
Chemokine mutanten, die als chemokine antagonisten wirkenInfo
- Publication number
- DE60231057D1 DE60231057D1 DE60231057T DE60231057T DE60231057D1 DE 60231057 D1 DE60231057 D1 DE 60231057D1 DE 60231057 T DE60231057 T DE 60231057T DE 60231057 T DE60231057 T DE 60231057T DE 60231057 D1 DE60231057 D1 DE 60231057D1
- Authority
- DE
- Germany
- Prior art keywords
- chemokine
- mutants
- working
- antagonists
- chemokine antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102000019034 Chemokines Human genes 0.000 title 2
- 108010012236 Chemokines Proteins 0.000 title 2
- 108010040471 CC Chemokines Proteins 0.000 abstract 2
- 102000001902 CC Chemokines Human genes 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 102100032367 C-C motif chemokine 5 Human genes 0.000 abstract 1
- 108010055166 Chemokine CCL5 Proteins 0.000 abstract 1
- 102000001327 Chemokine CCL5 Human genes 0.000 abstract 1
- 108091035707 Consensus sequence Proteins 0.000 abstract 1
- 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01000761 | 2001-12-17 | ||
| PCT/EP2002/014325 WO2003051921A1 (en) | 2001-12-17 | 2002-12-16 | Chemokine mutants acting as chemokine antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60231057D1 true DE60231057D1 (de) | 2009-03-19 |
Family
ID=8176112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60231057T Expired - Lifetime DE60231057D1 (de) | 2001-12-17 | 2002-12-16 | Chemokine mutanten, die als chemokine antagonisten wirken |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7553483B2 (enExample) |
| EP (1) | EP1458756B1 (enExample) |
| JP (1) | JP2005525089A (enExample) |
| AT (1) | ATE421974T1 (enExample) |
| AU (1) | AU2002358144B2 (enExample) |
| CA (1) | CA2468790A1 (enExample) |
| DE (1) | DE60231057D1 (enExample) |
| ES (1) | ES2320743T3 (enExample) |
| IL (1) | IL162600A0 (enExample) |
| WO (1) | WO2003051921A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE394117T1 (de) | 2002-12-23 | 2008-05-15 | Serono Lab | Verwendung von cc-chemokine ccl5/rantes mutanten zur behandlung von lebererkrankungen |
| DK1439191T3 (da) * | 2004-01-19 | 2006-08-14 | Ares Trading Sa | Proces til oprensning af bakterielt udtrykte proteiner |
| WO2008134020A1 (en) * | 2007-04-26 | 2008-11-06 | University Of Vermont And State Agricultural College | Ccl18 and ccl3 methods and compositions for detecting and treating cancer |
| AU2008317495B2 (en) | 2007-08-02 | 2013-08-01 | Novimmune S.A. | Anti-RANTES antibodies and methods of use thereof |
| WO2010071610A1 (en) * | 2008-12-19 | 2010-06-24 | Agency For Science, Technology And Research (A*Star) | Severe chikungunya biomarkers |
| EP2380975A1 (de) * | 2010-04-22 | 2011-10-26 | Scil Proteins GmbH | Verfahren zur Herstellung von rekombinantem Thrombin |
| WO2011138785A2 (en) | 2010-05-05 | 2011-11-10 | Rappaport Family Institute For Research In The Medical Sciences | Use of ccl1 in therapy |
| US9717777B2 (en) | 2010-05-05 | 2017-08-01 | Rappaport Family Institute For Research In The Medical Sciences | Use of CCL1 in therapy |
| US10967015B2 (en) * | 2015-06-15 | 2021-04-06 | New York University | Method of treatment using oncolytic viruses |
| WO2017077062A1 (en) * | 2015-11-05 | 2017-05-11 | Ludwig-Maximilians-Universität München | A peptide derived from human neutrophile peptide 1 |
| KR102682118B1 (ko) | 2016-04-29 | 2024-07-08 | 주식회사유한양행 | Ccl3 변이체를 포함하는 융합 단백질 및 이의 용도 |
| AU2022359841A1 (en) | 2021-10-06 | 2024-05-02 | Virothera Ltd | Novel immune regulator |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0627003A1 (en) | 1991-12-23 | 1994-12-07 | British Bio-Technology Limited | Stem cell inhibiting proteins |
| EP0796330A1 (en) * | 1994-12-08 | 1997-09-24 | Glaxo Group Limited | Rantes peptide and fragments and compositions comprising it for treatment of inflammation |
| WO1998024908A1 (en) | 1996-12-05 | 1998-06-11 | Human Genome Sciences, Inc. | Human chemokine beta-13 |
| WO1998024817A1 (fr) * | 1996-12-05 | 1998-06-11 | Kyowa Hakko Kogyo Co., Ltd. | Nouvel adn, nouvelle proteine et nouvel anticorps |
| EP0906954A1 (en) | 1997-09-29 | 1999-04-07 | Applied Research Systems ARS Holding N.V. | Amino-terminal truncated c-c chemokines as chemokine antagonist |
| DE69832197T2 (de) | 1997-12-23 | 2006-05-24 | Fondazione Centro San Raffaele Del Monte Tabor | Rantes-mutanten und therapeutische anwendungen davon |
| JPH11243960A (ja) | 1998-03-06 | 1999-09-14 | Shionogi & Co Ltd | ヒトｃｃ型ケモカインエオタキシン３ |
| CA2335105C (en) * | 1998-07-22 | 2010-05-11 | Osprey Pharmaceuticals Limited | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
| WO2000078334A1 (en) * | 1999-06-17 | 2000-12-28 | University Of Maryland Biotechnology Institute | Chimeric chemokine-antigen polypeptides and uses therefor |
| AU2001261024A1 (en) | 2000-04-12 | 2001-10-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| UA77950C2 (en) | 2000-10-04 | 2007-02-15 | Applied Research Systems | Use of mutants of cc chemokines for treatment of multiple sclerosis |
-
2002
- 2002-12-16 ES ES02791832T patent/ES2320743T3/es not_active Expired - Lifetime
- 2002-12-16 EP EP02791832A patent/EP1458756B1/en not_active Expired - Lifetime
- 2002-12-16 AT AT02791832T patent/ATE421974T1/de not_active IP Right Cessation
- 2002-12-16 CA CA002468790A patent/CA2468790A1/en not_active Abandoned
- 2002-12-16 JP JP2003552801A patent/JP2005525089A/ja active Pending
- 2002-12-16 AU AU2002358144A patent/AU2002358144B2/en not_active Ceased
- 2002-12-16 IL IL16260002A patent/IL162600A0/xx unknown
- 2002-12-16 WO PCT/EP2002/014325 patent/WO2003051921A1/en not_active Ceased
- 2002-12-16 US US10/499,100 patent/US7553483B2/en not_active Expired - Fee Related
- 2002-12-16 DE DE60231057T patent/DE60231057D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1458756A1 (en) | 2004-09-22 |
| EP1458756B1 (en) | 2009-01-28 |
| CA2468790A1 (en) | 2003-06-26 |
| AU2002358144A1 (en) | 2003-06-30 |
| ES2320743T3 (es) | 2009-05-28 |
| US7553483B2 (en) | 2009-06-30 |
| AU2002358144B2 (en) | 2008-10-02 |
| WO2003051921A1 (en) | 2003-06-26 |
| US20050220757A1 (en) | 2005-10-06 |
| ATE421974T1 (de) | 2009-02-15 |
| JP2005525089A (ja) | 2005-08-25 |
| IL162600A0 (en) | 2005-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |