WO2004005892A3 - Antimicrobial activity of interferon-inducible elr chemokines - Google Patents

Antimicrobial activity of interferon-inducible elr chemokines Download PDF

Info

Publication number
WO2004005892A3
WO2004005892A3 PCT/US2003/021848 US0321848W WO2004005892A3 WO 2004005892 A3 WO2004005892 A3 WO 2004005892A3 US 0321848 W US0321848 W US 0321848W WO 2004005892 A3 WO2004005892 A3 WO 2004005892A3
Authority
WO
WIPO (PCT)
Prior art keywords
ifn
inducible
chemokines
antimicrobial activity
interferon
Prior art date
Application number
PCT/US2003/021848
Other languages
French (fr)
Other versions
WO2004005892A2 (en
Inventor
Robert M Strieter
Marie D Burdick
Alexander M Cole
Tomas Ganz
Original Assignee
Univ California
Robert M Strieter
Marie D Burdick
Alexander M Cole
Tomas Ganz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Robert M Strieter, Marie D Burdick, Alexander M Cole, Tomas Ganz filed Critical Univ California
Priority to AU2003259117A priority Critical patent/AU2003259117A1/en
Publication of WO2004005892A2 publication Critical patent/WO2004005892A2/en
Publication of WO2004005892A3 publication Critical patent/WO2004005892A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention identifies and characterizes representative member chemoattractant molecules, or chemokines, which exert antimicrobial activity. More particularly, recombinant monokine induced by ifn-Ϝ, ifn-Ϝ-inducible protein of low molecular weight size, and ifn-inducible t cell α chemoattractant, and members of the ifn-inducible tripeptide motif glu-leu-arg (elr)-cxc chemokines are antimicrobial against bacteria including e. Coli and I. Monocytogenes. The concentration of at least two elr-cxc chemokines (ip-10/cxcl10 and mig/cxcl9) released from ifn-Ϝ-stimulated pbmc in 24 hours are about 25 to about 35-fold higher, respectively, than from unstimulated cells.
PCT/US2003/021848 2002-07-10 2003-07-10 Antimicrobial activity of interferon-inducible elr chemokines WO2004005892A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003259117A AU2003259117A1 (en) 2002-07-10 2003-07-10 Antimicrobial activity of interferon-inducible elr chemokines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39513502P 2002-07-10 2002-07-10
US60/395,135 2002-07-10

Publications (2)

Publication Number Publication Date
WO2004005892A2 WO2004005892A2 (en) 2004-01-15
WO2004005892A3 true WO2004005892A3 (en) 2006-06-15

Family

ID=30115820

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/021848 WO2004005892A2 (en) 2002-07-10 2003-07-10 Antimicrobial activity of interferon-inducible elr chemokines

Country Status (2)

Country Link
AU (1) AU2003259117A1 (en)
WO (1) WO2004005892A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100393742C (en) * 2005-07-27 2008-06-11 中山大学 Antibacterial tripeptides and modified chemicals, and application
US20120321687A1 (en) * 2010-02-19 2012-12-20 University Of Virginia Patent Foundation Compositions and methods for using and identifying antimicrobial agents
KR102152637B1 (en) * 2014-07-31 2020-09-08 (주)아모레퍼시픽 Composition for skin whitening containing a chemokine
CN108137505B (en) * 2015-07-17 2021-07-06 富士胶片株式会社 Nitrogen-containing heterocyclic compound
AU2017385292B2 (en) 2016-12-27 2020-05-14 Fujifilm Corporation Antitumor agent and bromodomain inhibitor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355252B1 (en) * 1997-02-21 2002-03-12 Isis Innovation Ltd. Soluble vaccinia virus protein that binds chemokines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355252B1 (en) * 1997-02-21 2002-03-12 Isis Innovation Ltd. Soluble vaccinia virus protein that binds chemokines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIU M.T. ET AL.: "The cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease", JOURNAL OF IMMUNOLOGY, vol. 165, no. 5, 1 September 2000 (2000-09-01), pages 2327 - 2330, XP002198987 *
LUSTER A.D.: "Chemokines - chemotactic cytokines that mediate inflammation", N. ENG. J. MED., vol. 338, no. 7, 12 February 1998 (1998-02-12), pages 436 - 445, XP008063963 *

Also Published As

Publication number Publication date
AU2003259117A8 (en) 2004-01-23
AU2003259117A1 (en) 2004-01-23
WO2004005892A2 (en) 2004-01-15

Similar Documents

Publication Publication Date Title
WO2007110231A3 (en) MODIFIED INTERFERON-β (IFN-β) POLYPEPTIDES
AU2003297244A1 (en) Methods and compositions for purification of nucleic acid from a host cell
DE69034204D1 (en) Leukocyte Adhesion / Endothelial Cell Molecules (ELAMs) and Molecules Effective in Leukocyte Adhesion (MILAs)
DK0720482T3 (en) Prosaposin and cytokine-derived peptides as therapeutic agents
ATE369434T1 (en) ADENO-ASSOCIATED VIRUS VECTORS AND THEIR USES
ATE367394T1 (en) ENHANCEMENT IN THE CELL OF PHOSPHONATE ANALOGUES OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS THEMSELVES
EP2014678A3 (en) KDR peptides and vaccines comprising the same
DE60239729D1 (en) MALE FERTILITY-DRIVING NUCLEOTIDE SEQUENCES AND THEIR USE
WO2004005892A3 (en) Antimicrobial activity of interferon-inducible elr chemokines
CA2380924A1 (en) Compositions for treating viral infections, and methods therefor
WO2004065406A3 (en) Rantes-derived peptides with anti-hiv activity
DE60231057D1 (en) CHEMOKINE MUTANTS WORKING AS CHEMOKINE ANTAGONISTS
GB2440089A (en) Regeneration system its production and use
WO2001040313A3 (en) Feline immunoregulatory proteins, nucleic acid molecules, and uses thereof
CA2495529A1 (en) Noonan syndrome gene
BR9811853A (en) Processes to increase yield in plants
CA2273855A1 (en) Novel feline fc epsilon receptor alpha chain nucleic acid molecules, proteins and uses thereof
SG146640A1 (en) Isolated photoprotein mtclytin, and use thereof
DE69934415D1 (en) NEW COLLECTIN
WO2000002913B1 (en) Chemotaxis-inhibiting protein of staphylococcus (chips) and its use
WO2003092736A3 (en) Peptide nucleic acid conjugates with transporter peptides
WO2002072632A3 (en) Nucleic acids of the human abcc11 gene, vectors containing such nucleic acids and uses thereof.
ATE465247T1 (en) IDENTIFICATION OF 3-KETOSTEROID 9-ALFA-HYDROXYLASE GENES AND BLOCKED MICROORGANISMS IN 3-KETOSTEROID 9-ALFA-HYDROXYLASE ACTIVITY
WO2002086067A3 (en) Mycobacterial sulfation pathway proteins and methods of use thereof
BR0313613A (en) Main allergen variants phl p 1 of timothy grass

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase