DE60226321D1 - Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren - Google Patents

Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren

Info

Publication number
DE60226321D1
DE60226321D1 DE60226321T DE60226321T DE60226321D1 DE 60226321 D1 DE60226321 D1 DE 60226321D1 DE 60226321 T DE60226321 T DE 60226321T DE 60226321 T DE60226321 T DE 60226321T DE 60226321 D1 DE60226321 D1 DE 60226321D1
Authority
DE
Germany
Prior art keywords
compositions
systemic administration
methods
sequences
code
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60226321T
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English (en)
Other versions
DE60226321T2 (de
Inventor
Brian Clancy
Debra D Pittman
Howard Seeherman
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Wyeth LLC
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Wyeth LLC
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Filing date
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Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of DE60226321D1 publication Critical patent/DE60226321D1/de
Application granted granted Critical
Publication of DE60226321T2 publication Critical patent/DE60226321T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
DE60226321T 2001-06-01 2002-05-31 Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren Expired - Fee Related DE60226321T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29515301P 2001-06-01 2001-06-01
US295153P 2001-06-01
PCT/US2002/017011 WO2002099037A2 (en) 2001-06-01 2002-05-31 Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins

Publications (2)

Publication Number Publication Date
DE60226321D1 true DE60226321D1 (de) 2008-06-12
DE60226321T2 DE60226321T2 (de) 2009-07-09

Family

ID=23136452

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60226321T Expired - Fee Related DE60226321T2 (de) 2001-06-01 2002-05-31 Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren

Country Status (11)

Country Link
US (2) US7226587B2 (de)
EP (1) EP1399023B1 (de)
JP (1) JP2005500280A (de)
AT (1) ATE393573T1 (de)
CA (1) CA2449008A1 (de)
DE (1) DE60226321T2 (de)
DK (1) DK1399023T3 (de)
ES (1) ES2305246T3 (de)
HK (1) HK1063201A1 (de)
NZ (1) NZ530045A (de)
WO (1) WO2002099037A2 (de)

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US20050272678A1 (en) * 2004-02-11 2005-12-08 Bodine Peter Van N BMP-6 estrogen responsive element and methods of use thereof
AU2006230434A1 (en) * 2005-03-30 2006-10-05 Wyeth Methods for stimulating hair growth by administering BMPs
US8911759B2 (en) * 2005-11-01 2014-12-16 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
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EP3147296A1 (de) 2005-11-14 2017-03-29 Merial, Inc. Gentherapie für nierenversagen
US7790161B2 (en) * 2006-03-28 2010-09-07 Wyeth Llc GDF-9/BMP-15 modulators for the treatment of bone disorders
US8034014B2 (en) * 2007-03-06 2011-10-11 Biomet Biologics, Llc Angiogenesis initation and growth
EP2331057B1 (de) * 2008-09-10 2019-03-20 University of Bradford Zusammensetzungen und verfahren zur modulation der pigmentierung der haut
US10136891B2 (en) * 2015-03-25 2018-11-27 Ethicon Llc Naturally derived bioabsorbable polymer gel adhesive for releasably attaching a staple buttress to a surgical stapler
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WO2002099037A3 (en) 2003-02-27
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US20060099186A1 (en) 2006-05-11
HK1063201A1 (en) 2004-12-17
EP1399023A4 (de) 2006-02-01
EP1399023A2 (de) 2004-03-24
ES2305246T3 (es) 2008-11-01
CA2449008A1 (en) 2002-12-12
EP1399023B1 (de) 2008-04-30
ATE393573T1 (de) 2008-05-15
NZ530045A (en) 2007-07-27
WO2002099037A2 (en) 2002-12-12
US20030170208A1 (en) 2003-09-11
JP2005500280A (ja) 2005-01-06
DE60226321T2 (de) 2009-07-09

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