DE60223950D1 - Katonische amphiphile zur intrazellulären verabreichung therapeutischer moleküle, zusammensetzung, verfahren sowie deren verwendung - Google Patents
Katonische amphiphile zur intrazellulären verabreichung therapeutischer moleküle, zusammensetzung, verfahren sowie deren verwendungInfo
- Publication number
- DE60223950D1 DE60223950D1 DE60223950T DE60223950T DE60223950D1 DE 60223950 D1 DE60223950 D1 DE 60223950D1 DE 60223950 T DE60223950 T DE 60223950T DE 60223950 T DE60223950 T DE 60223950T DE 60223950 D1 DE60223950 D1 DE 60223950D1
- Authority
- DE
- Germany
- Prior art keywords
- amphiphiles
- intra
- catalyst
- composition
- therapeutic molecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2002/001148 WO2003080847A1 (en) | 2002-03-26 | 2002-03-26 | Cationic amphiphiles for intracellular delivery of therapeutic molecules its composition, process and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60223950D1 true DE60223950D1 (de) | 2008-01-17 |
DE60223950T2 DE60223950T2 (de) | 2008-11-13 |
Family
ID=28053166
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60223950T Expired - Lifetime DE60223950T2 (de) | 2002-03-26 | 2002-03-26 | Katonische amphiphile zur intrazellulären verabreichung therapeutischer moleküle, zusammensetzung, verfahren sowie deren verwendung |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1492876B1 (de) |
JP (1) | JP4252461B2 (de) |
AU (1) | AU2002247919A1 (de) |
DE (1) | DE60223950T2 (de) |
WO (1) | WO2003080847A1 (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201726599A (zh) * | 2012-07-06 | 2017-08-01 | 協和醱酵麒麟有限公司 | 陽離子性脂質 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61258269A (ja) * | 1985-05-13 | 1986-11-15 | Canon Inc | 静電荷像現像用電荷付与材 |
JPS632904A (ja) * | 1986-06-20 | 1988-01-07 | Ss Pharmaceut Co Ltd | 植物生長調節剤 |
JPS63301813A (ja) * | 1987-06-01 | 1988-12-08 | Nichibai Boeki Kk | 抗齲蝕剤 |
JPS6445302A (en) * | 1987-08-13 | 1989-02-17 | Yoshinori Tsuda | Vermicide |
SK278487B6 (en) * | 1989-12-20 | 1997-07-09 | Ferdinand Devinsky | The algicidal and herbicidal agent based on the organic mono ammoniacal bromides |
US5266567A (en) * | 1991-10-24 | 1993-11-30 | Rohm And Haas Company | Halopropargylated cyclic quaternary ammonium compounds as antimicrobial agents |
US5527928A (en) * | 1994-09-30 | 1996-06-18 | Nantz; Michael H. | Cationic transport reagents |
US5935936A (en) * | 1996-06-03 | 1999-08-10 | Genzyme Corporation | Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules |
CA2216765A1 (en) * | 1996-10-11 | 1998-04-11 | Rohm And Haas Company | Halopropargyl compounds as marine antifouling agents |
WO2001042200A1 (en) * | 1999-12-10 | 2001-06-14 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
FR2802925B1 (fr) * | 1999-12-23 | 2002-03-22 | Commissariat Energie Atomique | Amphiphiles cationiques, leurs applications et leur procede de synthese |
-
2002
- 2002-03-26 AU AU2002247919A patent/AU2002247919A1/en not_active Abandoned
- 2002-03-26 JP JP2003578572A patent/JP4252461B2/ja not_active Expired - Fee Related
- 2002-03-26 EP EP02716998A patent/EP1492876B1/de not_active Expired - Fee Related
- 2002-03-26 DE DE60223950T patent/DE60223950T2/de not_active Expired - Lifetime
- 2002-03-26 WO PCT/IB2002/001148 patent/WO2003080847A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DE60223950T2 (de) | 2008-11-13 |
EP1492876A1 (de) | 2005-01-05 |
JP4252461B2 (ja) | 2009-04-08 |
WO2003080847A1 (en) | 2003-10-02 |
EP1492876B1 (de) | 2007-12-05 |
AU2002247919A1 (en) | 2003-10-08 |
JP2005532278A (ja) | 2005-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |