DE60222734D1 - Mikropartikel und Verfahren zur deren Herstellung - Google Patents

Mikropartikel und Verfahren zur deren Herstellung

Info

Publication number
DE60222734D1
DE60222734D1 DE60222734T DE60222734T DE60222734D1 DE 60222734 D1 DE60222734 D1 DE 60222734D1 DE 60222734 T DE60222734 T DE 60222734T DE 60222734 T DE60222734 T DE 60222734T DE 60222734 D1 DE60222734 D1 DE 60222734D1
Authority
DE
Germany
Prior art keywords
active substance
microparticles
suspension
polymer
nano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60222734T
Other languages
English (en)
Other versions
DE60222734T2 (de
Inventor
Celal Dr Albayrak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALRISE Biosystems GmbH
Original Assignee
ALRISE Biosystems GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALRISE Biosystems GmbH filed Critical ALRISE Biosystems GmbH
Publication of DE60222734D1 publication Critical patent/DE60222734D1/de
Application granted granted Critical
Publication of DE60222734T2 publication Critical patent/DE60222734T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
DE60222734T 2002-03-15 2002-03-15 Mikropartikel und Verfahren zur deren Herstellung Expired - Lifetime DE60222734T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02005393A EP1344520B1 (de) 2002-03-15 2002-03-15 Mikropartikel und Verfahren zur deren Herstellung

Publications (2)

Publication Number Publication Date
DE60222734D1 true DE60222734D1 (de) 2007-11-15
DE60222734T2 DE60222734T2 (de) 2008-07-17

Family

ID=27763347

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60222734T Expired - Lifetime DE60222734T2 (de) 2002-03-15 2002-03-15 Mikropartikel und Verfahren zur deren Herstellung

Country Status (7)

Country Link
US (1) US8802148B2 (de)
EP (1) EP1344520B1 (de)
AT (1) ATE374598T1 (de)
AU (1) AU2003230658A1 (de)
DE (1) DE60222734T2 (de)
ES (1) ES2292655T3 (de)
WO (1) WO2003077887A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60222734T2 (de) * 2002-03-15 2008-07-17 Alrise Biosystems Gmbh Mikropartikel und Verfahren zur deren Herstellung
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
DE10351087A1 (de) * 2003-10-31 2005-05-25 Bayer Technology Services Gmbh Feste Wirkstoff-Formulierung
FR2869801B1 (fr) * 2004-05-05 2008-09-12 Ethypharm Sa Procede de preparation de compositions a liberation prolongee et utilisation de ces compositions pour le traitement des affections chroniques du systeme nerveux central (snc)
RU2464972C2 (ru) * 2005-12-22 2012-10-27 Новартис Аг Композиции с замедленным высвобождением, включающие октреотид и два или более сополимера полилактида и гликолида
EP2078052B1 (de) * 2006-10-31 2010-07-28 Surmodics Pharmaceuticals, Inc. Kugelförmige polymer-teilchen
US8946200B2 (en) * 2006-11-02 2015-02-03 Southwest Research Institute Pharmaceutically active nanosuspensions
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
CA2682826C (en) 2007-04-02 2013-08-13 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
CN101821322B (zh) 2007-06-22 2012-12-05 Fio公司 制备量子点掺杂的聚合物微珠的系统和方法
US8551786B2 (en) * 2007-07-09 2013-10-08 Fio Corporation Systems and methods for enhancing fluorescent detection of target molecules in a test sample
US20100257027A1 (en) * 2007-07-23 2010-10-07 Fio Corporation Method and system for collating, storing, analyzing and enabling access to collected and analyzed data associated with biological and environmental test subjects
WO2009046540A1 (en) * 2007-10-12 2009-04-16 Fio Corporation Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto
US8404850B2 (en) * 2008-03-13 2013-03-26 Southwest Research Institute Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors
US8652506B2 (en) * 2008-06-05 2014-02-18 Boston Scientific Scimed, Inc. Bio-degradable block co-polymers for controlled release
BRPI0915514A2 (pt) 2008-06-25 2016-01-26 Fio Corp sistema e método de infra-estrutura de alerta de ameaça biológica, dispositivo de alerta de ameaça biológica e um método para alertar um usuário do mesmo
US8722706B2 (en) * 2008-08-15 2014-05-13 Southwest Research Institute Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts
CA2735273A1 (en) 2008-08-29 2010-03-04 Fio Corporation A single-use handheld diagnostic test device, and an associated system and method for testing biological and environmental test samples
US8309134B2 (en) * 2008-10-03 2012-11-13 Southwest Research Institute Modified calcium phosphate nanoparticle formation
RU2578023C2 (ru) 2009-01-13 2016-03-20 Эф-Ай-Оу Корпорейшн Портативный диагностический прибор и способ его применения с электронным устройством и диагностическим картриджем при диагностическом экспресс-исследовании
US8410455B2 (en) * 2009-04-17 2013-04-02 University Of Florida Research Foundation, Inc. Excitation-intensity-dependent, color-tunable, dual emitting nanocrystals
US9028873B2 (en) * 2010-02-08 2015-05-12 Southwest Research Institute Nanoparticles for drug delivery to the central nervous system
WO2011163469A1 (en) 2010-06-23 2011-12-29 Teva Pharmaceutical Industries Ltd. Hydrated form of anti-inflammatory roflumilast-n-oxide
GB201016433D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Apparatus and method for making solid beads
GB201016436D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Method of making solid beads
US8652366B2 (en) * 2010-11-01 2014-02-18 Board Of Regents, The University Of Texas System Aerosol-mediated particle synthesis
US20160303102A1 (en) * 2013-12-05 2016-10-20 Alrise Biosystems Gmbh Process for the production of drug formulations for oral administration
EP3307245A1 (de) 2015-06-11 2018-04-18 Alrise Biosystems GmbH Verfahren zur herstellung von mit arzneimitteln geladenen mikropartikeln

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2653255B2 (ja) * 1990-02-13 1997-09-17 武田薬品工業株式会社 長期徐放型マイクロカプセル
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
JP3277342B2 (ja) * 1992-09-02 2002-04-22 武田薬品工業株式会社 徐放性マイクロカプセルの製造法
GB9412273D0 (en) * 1994-06-18 1994-08-10 Univ Nottingham Administration means
DE19508049C2 (de) * 1995-02-23 1997-02-06 Schering Ag Verwendung von Methylenmalondiesterderivaten zur Herstellung von gasenthaltenden Mikropartikeln
DE19510690A1 (de) * 1995-03-14 1996-09-19 Schering Ag Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie
DE19545257A1 (de) * 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
DE19611769A1 (de) * 1996-03-14 1997-09-18 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie deren Verwendung in der Ultraschall Diagnostik
US5858531A (en) * 1996-10-24 1999-01-12 Bio Syntech Method for preparation of polymer microparticles free of organic solvent traces
US20030049320A1 (en) * 2000-12-18 2003-03-13 Wockhardt Limited Novel in-situ forming controlled release microcarrier delivery system
ATE361057T1 (de) * 2000-12-21 2007-05-15 Alrise Biosystems Gmbh Verfahren umfassend einen induzierten phasenübergang zur herstellung von hydrophobe wirkstoffe enthaltenden mikropartikeln
US20040126900A1 (en) * 2001-04-13 2004-07-01 Barry Stephen E High affinity peptide- containing nanoparticles
US7081489B2 (en) * 2001-08-09 2006-07-25 Florida State University Research Foundation Polymeric encapsulation of nanoparticles
DE60222734T2 (de) * 2002-03-15 2008-07-17 Alrise Biosystems Gmbh Mikropartikel und Verfahren zur deren Herstellung

Also Published As

Publication number Publication date
WO2003077887A1 (en) 2003-09-25
ES2292655T3 (es) 2008-03-16
EP1344520B1 (de) 2007-10-03
US20050106257A1 (en) 2005-05-19
ATE374598T1 (de) 2007-10-15
DE60222734T2 (de) 2008-07-17
EP1344520A1 (de) 2003-09-17
US8802148B2 (en) 2014-08-12
AU2003230658A1 (en) 2003-09-29

Similar Documents

Publication Publication Date Title
DE60222734D1 (de) Mikropartikel und Verfahren zur deren Herstellung
ATE319432T1 (de) Verfahren zur herstellung von submikropartikel- suspensionen pharmazeutischer substanzen
ATE256458T1 (de) Verfahren zur mikroverkapselung von wasserlöslichen substanzen
DK1765294T3 (da) Nukleinsyremikrokugler samt deres fremstilling og afgivelse
DE60328421D1 (de) Verfahren zur herstellung von super-hydrophoben oberflächen, daraus hergestellte oberflächen und deren verwendung
DE602004020538D1 (de) Verfahren und Vorrichtung zur Laserbestrahlung, sowie Verfahren zur Herstellung von Halbleiter.
DE50104019D1 (de) Verfahren zur agglomeration dispergierter kautschuke
ATE342316T1 (de) Verfahren zur herstellung von mikroperlen die fettlösliche substanzen enthalten
ATE405606T1 (de) Poröse polymerische vesikel sowie verfahren zu deren herstellung
ATE481362T1 (de) Verfahren zur herstellung von hydrophob modifizierten polymere
ATE426586T1 (de) Verfahren zur herstellung von cyclohexanon und cyclohexanol
ATE334136T1 (de) Verfahren zur herstellung von azithromycin
DE502005001316D1 (de) Verfahren zur herstellung von gut in wasser redispergierbaren polymerisatpulvern
ATE404588T1 (de) Verfahren zur herstellung von chondroitinsulfaten aus k4-polysaccharid und so hergestellte produkte
DE60143261D1 (de) Hämatologie-blutkontrolle und verfahren zu ihrer herstellung
TW200722461A (en) Method of producing cyclic polyolefin film, cyclic polyolefin film produced by the production method, method of preparing liquid dispersion of fine particles, liquid dispersion of fine particles and method of preparing dope
ATE506346T1 (de) Verfahren zur herstellung von (z)-1-phenyl-1-(n,n-diethylaminocarbonyl)idomet ylcyclopropan
ATE235475T1 (de) Intermediate und verfahren zur herstellung optisch aktiver oktansäure-derivate
DE602004026096D1 (de) Verfahren zur herstellung von polyacrolein
EP2324864A4 (de) Verbundmaterial mit einer matrix von hohem molekulargewicht und einem verbundstoff von niedrigem molekulargewicht sowie verfahren zu seiner herstellung
DE60130575D1 (de) Verfahren zur herstellung von acylphenylalaninen
ATE503747T1 (de) Verfahren zur herstellung von 6,7-bis(2- methoxyethoxy)-chinazolin-4-on
ATE402162T1 (de) Verfahren zur aufreinigung von thioctansäure in wasser
DE60034765D1 (de) Verfahren zur herstellung von poly(p-dioxanon), und poly(p-dioxanon)-monofilament und verfahren zur herstellung desselben
ATE420168T1 (de) Verfahren zur herstellung von extrachromosomalen nukleinsäuremolekülen

Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: ALBAYRAK, CELAL DR., 82152 PLANEGG, DE

8364 No opposition during term of opposition