DE60221640T2 - Bimodale trockenpulverzusammensetzung zur inhalation - Google Patents
Bimodale trockenpulverzusammensetzung zur inhalation Download PDFInfo
- Publication number
- DE60221640T2 DE60221640T2 DE60221640T DE60221640T DE60221640T2 DE 60221640 T2 DE60221640 T2 DE 60221640T2 DE 60221640 T DE60221640 T DE 60221640T DE 60221640 T DE60221640 T DE 60221640T DE 60221640 T2 DE60221640 T2 DE 60221640T2
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- pharmaceutical composition
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- bimodal
- fine
- composition according
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- Expired - Lifetime
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- YAJCHEVQCOHZDC-QMMNLEPNSA-N actrapid Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3N=CNC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@H](C)CC)[C@H](C)CC)[C@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C(N)=O)C1=CNC=N1 YAJCHEVQCOHZDC-QMMNLEPNSA-N 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
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- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 229940125388 beta agonist Drugs 0.000 description 1
- 235000019406 chloropentafluoroethane Nutrition 0.000 description 1
- 229960003821 choline theophyllinate Drugs 0.000 description 1
- 239000013066 combination product Substances 0.000 description 1
- 229940127555 combination product Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical class OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
- 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 229940066493 expectorants Drugs 0.000 description 1
- UHCBBWUQDAVSMS-UHFFFAOYSA-N fluoroethane Chemical compound CCF UHCBBWUQDAVSMS-UHFFFAOYSA-N 0.000 description 1
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- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 description 1
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- 229960000193 formoterol fumarate Drugs 0.000 description 1
- 229960003610 formoterol fumarate dihydrate Drugs 0.000 description 1
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- 238000011835 investigation Methods 0.000 description 1
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- 229960004958 ketotifen Drugs 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229940071648 metered dose inhaler Drugs 0.000 description 1
- 229960002259 nedocromil sodium Drugs 0.000 description 1
- RLANKEDHRWMNRO-UHFFFAOYSA-M oxtriphylline Chemical compound C[N+](C)(C)CCO.O=C1N(C)C(=O)N(C)C2=C1[N-]C=N2 RLANKEDHRWMNRO-UHFFFAOYSA-M 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0102902 | 2001-02-06 | ||
| GBGB0102902.4A GB0102902D0 (en) | 2001-02-06 | 2001-02-06 | Medicaments |
| GB0109215 | 2001-04-12 | ||
| GB0109215A GB0109215D0 (en) | 2001-04-12 | 2001-04-12 | Medicaments |
| PCT/GB2002/000480 WO2002062317A2 (en) | 2001-02-06 | 2002-02-05 | Bimodal dry powder formulation for inhalation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60221640D1 DE60221640D1 (de) | 2007-09-20 |
| DE60221640T2 true DE60221640T2 (de) | 2008-05-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60221640T Expired - Lifetime DE60221640T2 (de) | 2001-02-06 | 2002-02-05 | Bimodale trockenpulverzusammensetzung zur inhalation |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20060292085A1 (enExample) |
| EP (1) | EP1359902B1 (enExample) |
| JP (1) | JP5154732B2 (enExample) |
| AT (1) | ATE369121T1 (enExample) |
| BR (1) | BR0207062A (enExample) |
| CA (1) | CA2435982C (enExample) |
| DE (1) | DE60221640T2 (enExample) |
| ES (1) | ES2291452T3 (enExample) |
| MX (1) | MXPA03007017A (enExample) |
| NO (1) | NO20033451L (enExample) |
| PL (1) | PL365736A1 (enExample) |
| WO (1) | WO2002062317A2 (enExample) |
Families Citing this family (6)
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|---|---|---|---|---|
| US6962151B1 (en) * | 1999-11-05 | 2005-11-08 | Pari GmbH Spezialisten für effektive Inhalation | Inhalation nebulizer |
| US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
| WO2004052374A1 (en) * | 2002-12-12 | 2004-06-24 | Altana Pharma Ag | Combination medicament |
| TWI359675B (en) | 2003-07-10 | 2012-03-11 | Dey L P | Bronchodilating β-agonist compositions |
| AU2014248455B2 (en) | 2013-04-01 | 2018-12-06 | Pulmatrix Operating Company, Inc. | Tiotropium dry powders |
| CA2965759C (en) | 2014-10-31 | 2023-12-12 | Glaxosmithkline Intellectual Property Development Limited | Powdered polypeptides with decreased disulfide impurities comprising divalent cationic materials |
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| US385626A (en) * | 1888-07-03 | Farm-gate | ||
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| LU53824A1 (enExample) * | 1967-06-06 | 1969-03-24 | ||
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-
2002
- 2002-02-05 BR BR0207062-6A patent/BR0207062A/pt not_active Application Discontinuation
- 2002-02-05 JP JP2002562324A patent/JP5154732B2/ja not_active Expired - Fee Related
- 2002-02-05 AT AT02712031T patent/ATE369121T1/de active
- 2002-02-05 ES ES02712031T patent/ES2291452T3/es not_active Expired - Lifetime
- 2002-02-05 EP EP02712031A patent/EP1359902B1/en not_active Revoked
- 2002-02-05 WO PCT/GB2002/000480 patent/WO2002062317A2/en not_active Ceased
- 2002-02-05 CA CA2435982A patent/CA2435982C/en not_active Expired - Fee Related
- 2002-02-05 DE DE60221640T patent/DE60221640T2/de not_active Expired - Lifetime
- 2002-02-05 PL PL02365736A patent/PL365736A1/xx unknown
- 2002-02-05 MX MXPA03007017A patent/MXPA03007017A/es unknown
-
2003
- 2003-08-04 NO NO20033451A patent/NO20033451L/no not_active Application Discontinuation
-
2006
- 2006-08-29 US US11/511,730 patent/US20060292085A1/en not_active Abandoned
-
2010
- 2010-01-07 US US12/683,959 patent/US20100136121A1/en not_active Abandoned
-
2014
- 2014-07-31 US US14/448,493 patent/US20140342001A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP5154732B2 (ja) | 2013-02-27 |
| US20060292085A1 (en) | 2006-12-28 |
| ES2291452T3 (es) | 2008-03-01 |
| CA2435982C (en) | 2014-05-06 |
| NO20033451L (no) | 2003-10-03 |
| MXPA03007017A (es) | 2004-09-13 |
| US20140342001A1 (en) | 2014-11-20 |
| US20100136121A1 (en) | 2010-06-03 |
| WO2002062317A2 (en) | 2002-08-15 |
| NO20033451D0 (no) | 2003-08-04 |
| WO2002062317A3 (en) | 2002-11-21 |
| EP1359902B1 (en) | 2007-08-08 |
| CA2435982A1 (en) | 2002-08-15 |
| EP1359902A2 (en) | 2003-11-12 |
| BR0207062A (pt) | 2004-10-05 |
| DE60221640D1 (de) | 2007-09-20 |
| PL365736A1 (en) | 2005-01-10 |
| ATE369121T1 (de) | 2007-08-15 |
| JP2004523536A (ja) | 2004-08-05 |
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| 8363 | Opposition against the patent |