DE60220305D1 - Verbrückte bicyclische (1,4) benzodiazepine als vasopressinrezeptorantagonisten - Google Patents
Verbrückte bicyclische (1,4) benzodiazepine als vasopressinrezeptorantagonistenInfo
- Publication number
- DE60220305D1 DE60220305D1 DE60220305T DE60220305T DE60220305D1 DE 60220305 D1 DE60220305 D1 DE 60220305D1 DE 60220305 T DE60220305 T DE 60220305T DE 60220305 T DE60220305 T DE 60220305T DE 60220305 D1 DE60220305 D1 DE 60220305D1
- Authority
- DE
- Germany
- Prior art keywords
- receptor antagonists
- benzodiazepines
- bicyclic
- broken
- vasopressin receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002536 vasopressin receptor antagonist Substances 0.000 title abstract 2
- 229940049706 benzodiazepine Drugs 0.000 title 1
- 150000001557 benzodiazepines Chemical class 0.000 title 1
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical class N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 abstract 1
- GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 abstract 1
- 102000002852 Vasopressins Human genes 0.000 abstract 1
- 108010004977 Vasopressins Proteins 0.000 abstract 1
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 abstract 1
- -1 bicyclic amino acid Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960003726 vasopressin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34104901P | 2001-10-29 | 2001-10-29 | |
| US341049P | 2001-10-29 | ||
| PCT/US2002/032789 WO2003037901A1 (en) | 2001-10-29 | 2002-10-11 | Bridged bicycle (1,4) benzodiazepine vasopressin receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60220305D1 true DE60220305D1 (de) | 2007-07-05 |
| DE60220305T2 DE60220305T2 (de) | 2008-01-17 |
Family
ID=23336043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60220305T Expired - Fee Related DE60220305T2 (de) | 2001-10-29 | 2002-10-11 | Verbrückte bicyclische (1,4) benzodiazepine als vasopressinrezeptorantagonisten |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6936604B2 (de) |
| EP (1) | EP1442040B1 (de) |
| JP (1) | JP2005507939A (de) |
| KR (1) | KR20050035173A (de) |
| CN (1) | CN1608068A (de) |
| AT (1) | ATE362934T1 (de) |
| CA (1) | CA2465497A1 (de) |
| DE (1) | DE60220305T2 (de) |
| ES (1) | ES2287326T3 (de) |
| HU (1) | HUP0401722A3 (de) |
| PL (1) | PL370114A1 (de) |
| WO (1) | WO2003037901A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1809296A4 (de) * | 2004-10-28 | 2009-03-11 | Janssen Pharmaceutica Nv | Neue [1,4]-benzodiazepine als vasopressin v2-rezeptorantagonisten |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3860600A (en) * | 1972-07-10 | 1975-01-14 | Sterling Drug Inc | Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines |
| US5258510A (en) * | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
| US5985869A (en) * | 1989-10-20 | 1999-11-16 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
| US5521173A (en) * | 1995-01-17 | 1996-05-28 | American Home Products Corporation | Tricyclic benzazepine vasopressin antagonists |
| US5700796A (en) * | 1995-01-17 | 1997-12-23 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| AU732214C (en) | 1997-03-31 | 2001-10-25 | Wakamoto Pharmaceutical Co., Ltd. | Biphenyl derivatives and drug composition |
| TR200102069T2 (tr) | 1999-01-19 | 2001-11-21 | Ortho-Mcneil Pharmaceutical, Inc. | Vasopresin reseptörü antagonistleri olarak trisiklik benzodiazepinler. |
-
2002
- 2002-10-11 PL PL02370114A patent/PL370114A1/xx not_active Application Discontinuation
- 2002-10-11 WO PCT/US2002/032789 patent/WO2003037901A1/en active IP Right Grant
- 2002-10-11 ES ES02778547T patent/ES2287326T3/es not_active Expired - Lifetime
- 2002-10-11 AT AT02778547T patent/ATE362934T1/de not_active IP Right Cessation
- 2002-10-11 JP JP2003540182A patent/JP2005507939A/ja not_active Withdrawn
- 2002-10-11 CA CA002465497A patent/CA2465497A1/en not_active Abandoned
- 2002-10-11 EP EP02778547A patent/EP1442040B1/de not_active Expired - Lifetime
- 2002-10-11 CN CNA028261682A patent/CN1608068A/zh active Pending
- 2002-10-11 HU HU0401722A patent/HUP0401722A3/hu unknown
- 2002-10-11 US US10/269,656 patent/US6936604B2/en not_active Expired - Lifetime
- 2002-10-11 KR KR1020047006413A patent/KR20050035173A/ko not_active Application Discontinuation
- 2002-10-11 DE DE60220305T patent/DE60220305T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20050035173A (ko) | 2005-04-15 |
| US6936604B2 (en) | 2005-08-30 |
| HUP0401722A3 (en) | 2008-07-28 |
| ES2287326T3 (es) | 2007-12-16 |
| CN1608068A (zh) | 2005-04-20 |
| PL370114A1 (en) | 2005-05-16 |
| US20030119822A1 (en) | 2003-06-26 |
| EP1442040B1 (de) | 2007-05-23 |
| CA2465497A1 (en) | 2003-05-08 |
| WO2003037901A1 (en) | 2003-05-08 |
| EP1442040A1 (de) | 2004-08-04 |
| ATE362934T1 (de) | 2007-06-15 |
| DE60220305T2 (de) | 2008-01-17 |
| HUP0401722A2 (hu) | 2005-01-28 |
| JP2005507939A (ja) | 2005-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |