DE60213633T2 - Wortmanninanaloge und verfahren zu deren verwendung - Google Patents

Wortmanninanaloge und verfahren zu deren verwendung Download PDF

Info

Publication number
DE60213633T2
DE60213633T2 DE60213633T DE60213633T DE60213633T2 DE 60213633 T2 DE60213633 T2 DE 60213633T2 DE 60213633 T DE60213633 T DE 60213633T DE 60213633 T DE60213633 T DE 60213633T DE 60213633 T2 DE60213633 T2 DE 60213633T2
Authority
DE
Germany
Prior art keywords
wortmannin
compound
analogs
kinase
proliferation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60213633T
Other languages
German (de)
English (en)
Other versions
DE60213633D1 (de
Inventor
Peter Pittsburgh WIPF
Garth Tucson POWIS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
University of Arizona
Original Assignee
University of Pittsburgh
University of Arizona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh, University of Arizona filed Critical University of Pittsburgh
Application granted granted Critical
Publication of DE60213633D1 publication Critical patent/DE60213633D1/de
Publication of DE60213633T2 publication Critical patent/DE60213633T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pyrane Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
DE60213633T 2001-09-14 2002-09-16 Wortmanninanaloge und verfahren zu deren verwendung Expired - Lifetime DE60213633T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32214301P 2001-09-14 2001-09-14
US32213901P 2001-09-14 2001-09-14
US322143P 2001-09-14
US322139P 2001-09-14
PCT/US2002/029365 WO2003024183A2 (en) 2001-09-14 2002-09-16 Wortmannin analogs and methods of using same

Publications (2)

Publication Number Publication Date
DE60213633D1 DE60213633D1 (de) 2006-09-14
DE60213633T2 true DE60213633T2 (de) 2007-11-08

Family

ID=26983283

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60213633T Expired - Lifetime DE60213633T2 (de) 2001-09-14 2002-09-16 Wortmanninanaloge und verfahren zu deren verwendung

Country Status (8)

Country Link
EP (1) EP1435941B8 (cg-RX-API-DMAC7.html)
JP (1) JP4540986B2 (cg-RX-API-DMAC7.html)
AT (1) ATE334671T1 (cg-RX-API-DMAC7.html)
AU (1) AU2002330029B2 (cg-RX-API-DMAC7.html)
CA (1) CA2458318C (cg-RX-API-DMAC7.html)
DE (1) DE60213633T2 (cg-RX-API-DMAC7.html)
MX (1) MXPA04002445A (cg-RX-API-DMAC7.html)
WO (1) WO2003024183A2 (cg-RX-API-DMAC7.html)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7081475B2 (en) 2001-09-14 2006-07-25 Prolx Pharmaceuticals Corp. Wortmannin analogs and methods of using same
DE10219545A1 (de) * 2002-04-26 2003-11-06 Lang Florian Regulation der Apoptose
US7230139B2 (en) 2002-12-05 2007-06-12 Gemin X Biotechnologies Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents
WO2004093918A2 (en) * 2003-04-23 2004-11-04 Wyeth Holdings Corporation Peg-wortmannin conjugates
DE102004043463A1 (de) * 2004-06-09 2006-02-09 Heinz Voigt Mittel zur Krebsbekämpfung unter Verwendung von Schimmelpilzextrakten
US7446124B2 (en) 2004-07-09 2008-11-04 Prolx Pharmaceuticals Corp. Wortmannin analogs and methods of using same in combination with chemotherapeutic agents
BRPI0516592A (pt) 2004-10-13 2008-09-23 Wyeth Corp composto de fórmula
US8716299B2 (en) * 2004-12-20 2014-05-06 University Of South Florida XIAP-targeted prostate cancer therapy
EP1940386A4 (en) * 2005-09-01 2010-06-23 Beth Israel Hospital WORDMAN'S CONJUGATES AND USES THEREOF
US20070116736A1 (en) * 2005-11-23 2007-05-24 Argentieri Dennis C Local vascular delivery of PI3 kinase inhibitors alone or in combination with sirolimus to prevent restinosis following vascular injury
ATE536181T1 (de) 2005-12-30 2011-12-15 Univ Arizona Metabolite von wortmannin-analogen und verwendungsverfahren dafür
WO2007120897A2 (en) * 2006-04-13 2007-10-25 The Trustees Of Columbia University In The City Of New York Compositions and intraluminal devices for inhibiting vascular stenosis
AU2011261249A1 (en) * 2010-06-04 2012-12-20 Oncothyreon Inc. Cancer treatment with wortmannin analogs
EP2576535A4 (en) * 2010-06-04 2014-03-12 Oncothyreon Inc COMBINED CANCER THERAPIES WITH WORDMAN ANALOG
US11197854B1 (en) 2018-11-14 2021-12-14 National Technology & Engineering Solutions Of Sandia, Llc Inhibitors for targeting flaviviruses
BR112021011894A2 (pt) 2018-12-21 2021-09-08 Daiichi Sankyo Company, Limited Composição farmacêutica

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2302021A (en) * 1996-10-16 1997-01-08 Lilly Co Eli Inhibiting bone loss or resorption

Also Published As

Publication number Publication date
MXPA04002445A (es) 2005-07-25
EP1435941A2 (en) 2004-07-14
CA2458318C (en) 2011-03-15
WO2003024183A3 (en) 2003-06-12
WO2003024183A2 (en) 2003-03-27
EP1435941B8 (en) 2006-10-25
JP2005507880A (ja) 2005-03-24
AU2002330029B2 (en) 2006-07-06
EP1435941A4 (en) 2004-12-08
DE60213633D1 (de) 2006-09-14
CA2458318A1 (en) 2003-03-27
JP4540986B2 (ja) 2010-09-08
ATE334671T1 (de) 2006-08-15
EP1435941B1 (en) 2006-08-02

Similar Documents

Publication Publication Date Title
US6703414B2 (en) Device and method for treating restenosis
DE60213633T2 (de) Wortmanninanaloge und verfahren zu deren verwendung
CA2304770C (en) A use of steroidal saponins for the prophylaxis or treatment of dementia, and novel steroidal saponin compounds
DE60208385T2 (de) Antineoplastische kombinationspräparate
EP0641566A1 (en) Methods of inhibiting vascular restenosis
US7776908B2 (en) Wortmannin analogs and methods of using same
US6096740A (en) Dexanabinol derivatives and their use as neuroprotective pharmaceutical compositions
DE60027648T2 (de) Sulfonamide enthaltende indolderivate
WO1995020958A1 (en) Dexanabinol derivatives and their use as neuroprotective pharmaceutical compositions
AU2005333515B2 (en) Wortmannin analogs and methods of using same in combination with chemotherapeutic agents
AU2002330029A1 (en) Wortmannin analogs and methods of using same
DE69533194T2 (de) PYRAZOLO(3,4-g)CHINOXALINE ALS PDGF-REZEPTOR PROTEIN TYROSIN-KINASE INHIBITOREN
US5514706A (en) Pharmaceutical compounds
JPH06510280A (ja) タンパクキナーゼｃ阻害および新規化合物バラノール
US5789439A (en) Pharmaceutical use of forskolin derivatives
DE60007168T2 (de) Benzopyranyl-guanidin-derivate, verfahren zu deren herstellung sowie diese enthaltenden pharmazeutische zusammensetzungen
DE69916571T2 (de) Hemmer der angiogenese und der urokinase produktion und seine medizinische anwendung
EP1914230B1 (en) Wortmannin analogs and methods of using same
AU2006202635B2 (en) Wortmannin analogs and methods of using same
WO1992022545A1 (en) New coumarin derivatives
DE3410848A1 (de) Arzneimittel zur behandlung von tumoren in der metastasenphase
EP0573391A1 (de) Thiosemicarbazonsäureester und ihre Anwendung als Arzneimittelwirkstoff
EP0684231A1 (de) Pharmazeutisches Präparat zur Modulierung der Immunreaktion und neue Indol- und Chinolinderivate

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: ARIZONA BOARD OF REGENTS, ON BEHALF OF THE UNIVERS

Owner name: UNIVERSITY OF PITTSBURGH, PITTSBURGH, PA., US

8364 No opposition during term of opposition