DE60212959D1 - Eine sulfonimid-gruppe enthaltende oxazolidinone als antibiotika - Google Patents

Eine sulfonimid-gruppe enthaltende oxazolidinone als antibiotika

Info

Publication number
DE60212959D1
DE60212959D1 DE60212959T DE60212959T DE60212959D1 DE 60212959 D1 DE60212959 D1 DE 60212959D1 DE 60212959 T DE60212959 T DE 60212959T DE 60212959 T DE60212959 T DE 60212959T DE 60212959 D1 DE60212959 D1 DE 60212959D1
Authority
DE
Germany
Prior art keywords
antibiotics
group containing
sulfonimide group
membered
linked
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60212959T
Other languages
English (en)
Other versions
DE60212959T2 (de
Inventor
John Betts
Lingard Swain
James Hales
Khai Huynh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0108765A external-priority patent/GB0108765D0/en
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE60212959D1 publication Critical patent/DE60212959D1/de
Publication of DE60212959T2 publication Critical patent/DE60212959T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60212959T 2001-04-07 2002-04-03 Eine sulfonimid-gruppe enthaltende oxazolidinone als antibiotika Expired - Fee Related DE60212959T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0108765A GB0108765D0 (en) 2001-04-07 2001-04-07 Method
GB0108765 2001-04-07
US33058801P 2001-10-25 2001-10-25
US330588P 2001-10-25
PCT/GB2002/001644 WO2002081470A1 (en) 2001-04-07 2002-04-03 Oxazolidinones containing a sulfonimid group as antibiotics

Publications (2)

Publication Number Publication Date
DE60212959D1 true DE60212959D1 (de) 2006-08-17
DE60212959T2 DE60212959T2 (de) 2007-02-15

Family

ID=26245945

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60212959T Expired - Fee Related DE60212959T2 (de) 2001-04-07 2002-04-03 Eine sulfonimid-gruppe enthaltende oxazolidinone als antibiotika

Country Status (7)

Country Link
US (1) US20050032861A1 (de)
EP (1) EP1385844B1 (de)
JP (1) JP2004531518A (de)
AT (1) ATE332299T1 (de)
DE (1) DE60212959T2 (de)
ES (1) ES2268011T3 (de)
WO (1) WO2002081470A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1427711E (pt) 2001-09-11 2005-11-30 Astrazeneca Ab Derivados de oxazolidinona e/ou isoxazolina como agentes antibacterianos
BR0307103A (pt) * 2002-01-24 2004-12-28 Upjohn Co Dihidrotiazina e dihidrotiopirano oxazolidinovas antimicrobianas
NZ535591A (en) 2002-02-28 2006-07-28 Astrazeneca Ab Oxazolidinone derivatives, processes for their preparation, and pharmaceutical compositions containing them
BR0308056A (pt) * 2002-02-28 2004-12-07 Astrazeneca Ab Composto, pró-droga, método para a produção de um efeito antibacteriano em um animal de sangue quente, uso de um composto, composição farmacêutica, e, processo para a preparação de um composto
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
CA2507628A1 (en) * 2002-11-28 2004-06-10 Astrazeneca Ab Oxazolidinones as antibacterial agents
GB0306358D0 (en) 2003-03-20 2003-04-23 Astrazeneca Ab Chemical compounds
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
PT1656370E (pt) 2003-06-03 2012-11-29 Rib X Pharmaceuticals Inc Compostos biaril-heterocíclicos e métodos de os produzir e de os utilizar
TW200526649A (en) 2003-12-17 2005-08-16 Rib X Pharmaceuticals Inc Halogenated biaryl heterocyclic compounds and methods of making and using the same
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
AU2006231919A1 (en) 2005-04-06 2006-10-12 Pharmacia & Upjohn Company Llc 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
ATE496914T1 (de) 2005-06-08 2011-02-15 Rib X Pharmaceuticals Inc Verfahren zur synthese von triazolen
DE602006010702D1 (de) 2005-06-29 2010-01-07 Pharmacia & Upjohn Co Llc Homomorpholinoxazolidinone als antibakterielle mittel
WO2010042887A2 (en) 2008-10-10 2010-04-15 Trius Therapeutics Methods for preparing oxazolidinones and compositions containing them
US8841306B2 (en) 2008-11-20 2014-09-23 Panacea Biotec Ltd. Antimicrobials
AU2010210627B2 (en) 2009-02-03 2016-03-03 Merck Sharp & Dohme Llc Crystalline form of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US8580767B2 (en) 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
AU2010264027B9 (en) 2009-06-26 2013-06-13 Panacea Biotec Ltd. Novel azabicyclohexanes
EP2766373B1 (de) * 2011-10-11 2016-08-17 Council of Scientific & Industrial Research Sila-analoga von oxazolidinon-derivaten und ihre herstellung
WO2020147504A1 (en) * 2019-01-18 2020-07-23 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1222708A (en) * 1968-10-22 1971-02-17 Delalande Sa Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
ES2193201T3 (es) * 1994-11-15 2003-11-01 Upjohn Co Agentes antibacterianos tipo oxazolidonas sustituidas con oxazina y tiazina biciclica.
RU2175324C2 (ru) * 1995-09-01 2001-10-27 Фармация Энд Апджон Компани Фенилоксазолидиноны, имеющие с-с-связь с 4-8-членными гетероциклическими кольцами
CZ298060B6 (cs) * 1996-04-11 2007-06-06 Pharmacia & Upjohn Company Zpusob prípravy oxazolidinonu
DE19707628A1 (de) * 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
ATE293609T1 (de) * 1997-05-30 2005-05-15 Upjohn Co Antibakteriell wirksam oxazolidinone mit einer thiocarbonylfunktionalität
PL356478A1 (en) * 1999-12-21 2004-06-28 Pharmacia & Upjohn Company Oxazolidinones having a sulfoximine functionality and their use as antimicrobial agents

Also Published As

Publication number Publication date
ES2268011T3 (es) 2007-03-16
EP1385844B1 (de) 2006-07-05
EP1385844A1 (de) 2004-02-04
ATE332299T1 (de) 2006-07-15
DE60212959T2 (de) 2007-02-15
WO2002081470A1 (en) 2002-10-17
JP2004531518A (ja) 2004-10-14
US20050032861A1 (en) 2005-02-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee