ATE386031T1 - Benzoylaminopyridylcarbonsäurederivate als glucokinaseaktivatoren - Google Patents
Benzoylaminopyridylcarbonsäurederivate als glucokinaseaktivatorenInfo
- Publication number
- ATE386031T1 ATE386031T1 AT04798661T AT04798661T ATE386031T1 AT E386031 T1 ATE386031 T1 AT E386031T1 AT 04798661 T AT04798661 T AT 04798661T AT 04798661 T AT04798661 T AT 04798661T AT E386031 T1 ATE386031 T1 AT E386031T1
- Authority
- AT
- Austria
- Prior art keywords
- benzoylaminopyridyl
- carboxylic acid
- acid derivatives
- glucokinase activators
- methyl
- Prior art date
Links
- 239000012190 activator Substances 0.000 title abstract 2
- IYUARXLBPNSYLE-UHFFFAOYSA-N 3-benzamidopyridine-2-carboxylic acid Chemical class OC(=O)C1=NC=CC=C1NC(=O)C1=CC=CC=C1 IYUARXLBPNSYLE-UHFFFAOYSA-N 0.000 title 1
- 102000030595 Glucokinase Human genes 0.000 title 1
- 108010021582 Glucokinase Proteins 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- External Artificial Organs (AREA)
- Feeding And Guiding Record Carriers (AREA)
- Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0327760.5A GB0327760D0 (en) | 2003-11-29 | 2003-11-29 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE386031T1 true ATE386031T1 (de) | 2008-03-15 |
Family
ID=29798044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04798661T ATE386031T1 (de) | 2003-11-29 | 2004-11-25 | Benzoylaminopyridylcarbonsäurederivate als glucokinaseaktivatoren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090018157A1 (de) |
| EP (1) | EP1689741B1 (de) |
| JP (1) | JP2007512300A (de) |
| CN (1) | CN1886401A (de) |
| AT (1) | ATE386031T1 (de) |
| DE (1) | DE602004011814T2 (de) |
| ES (1) | ES2299886T3 (de) |
| GB (1) | GB0327760D0 (de) |
| WO (1) | WO2005054233A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| ATE426597T1 (de) * | 2004-02-18 | 2009-04-15 | Astrazeneca Ab | Benzamidderivate und deren verwendung als glucokinaseaktivierende mittel |
| TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
| US7642259B2 (en) * | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
| JP2009500442A (ja) * | 2005-07-09 | 2009-01-08 | アストラゼネカ アクチボラグ | ２型糖尿病を処置するためのグルコキナーゼのモジュレーターとしての２−ヘテロシクリルオキシベンゾイルアミノヘテロシクリル化合物 |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| JP2009509988A (ja) | 2005-09-29 | 2009-03-12 | サノフィ−アベンティス | フェニル−及びピリジニル−１，２，４−オキサジアゾロン誘導体、その製造方法、及び医薬品としてのその使用 |
| US8034822B2 (en) | 2006-03-08 | 2011-10-11 | Takeda San Diego, Inc. | Glucokinase activators |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| US8008332B2 (en) | 2006-05-31 | 2011-08-30 | Takeda San Diego, Inc. | Substituted indazoles as glucokinase activators |
| SA07280576B1 (ar) * | 2006-10-26 | 2011-06-22 | استرازينيكا ايه بي | مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز |
| WO2008079787A2 (en) | 2006-12-20 | 2008-07-03 | Takeda San Diego, Inc. | Glucokinase activators |
| US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
| MX2011001333A (es) | 2008-08-04 | 2011-03-15 | Astrazeneca Ab | Derivados de pirazolo [3, 4] pirimidin-4-ilo y sus usos para tratar la diabetes y obesidad. |
| GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
| GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
| AR076221A1 (es) * | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad |
| WO2010116177A1 (en) | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102300D0 (sv) * | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
-
2003
- 2003-11-29 GB GBGB0327760.5A patent/GB0327760D0/en not_active Ceased
-
2004
- 2004-11-25 CN CNA2004800353262A patent/CN1886401A/zh active Pending
- 2004-11-25 ES ES04798661T patent/ES2299886T3/es not_active Expired - Lifetime
- 2004-11-25 US US10/579,552 patent/US20090018157A1/en not_active Abandoned
- 2004-11-25 DE DE602004011814T patent/DE602004011814T2/de not_active Expired - Fee Related
- 2004-11-25 EP EP04798661A patent/EP1689741B1/de not_active Expired - Lifetime
- 2004-11-25 JP JP2006540608A patent/JP2007512300A/ja not_active Withdrawn
- 2004-11-25 AT AT04798661T patent/ATE386031T1/de not_active IP Right Cessation
- 2004-11-25 WO PCT/GB2004/004956 patent/WO2005054233A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005054233A1 (en) | 2005-06-16 |
| GB0327760D0 (en) | 2003-12-31 |
| CN1886401A (zh) | 2006-12-27 |
| DE602004011814D1 (en) | 2008-03-27 |
| JP2007512300A (ja) | 2007-05-17 |
| US20090018157A1 (en) | 2009-01-15 |
| HK1092803A1 (en) | 2007-02-16 |
| ES2299886T3 (es) | 2008-06-01 |
| EP1689741B1 (de) | 2008-02-13 |
| EP1689741A1 (de) | 2006-08-16 |
| DE602004011814T2 (de) | 2009-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |