DE60208534T2 - Verwendung von antikörper gegen mag zur behandlung ischämischer schlaganfälle - Google Patents
Verwendung von antikörper gegen mag zur behandlung ischämischer schlaganfälle Download PDFInfo
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- DE60208534T2 DE60208534T2 DE60208534T DE60208534T DE60208534T2 DE 60208534 T2 DE60208534 T2 DE 60208534T2 DE 60208534 T DE60208534 T DE 60208534T DE 60208534 T DE60208534 T DE 60208534T DE 60208534 T2 DE60208534 T2 DE 60208534T2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0103174.9A GB0103174D0 (en) | 2001-02-08 | 2001-02-08 | Novel method of treatment |
| GB0103174 | 2001-02-08 | ||
| PCT/GB2002/000551 WO2002062383A2 (en) | 2001-02-08 | 2002-02-08 | Antagonists of myelin-associated glycoprotein and their use in the treatment and/or prevention of neurological diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60208534D1 DE60208534D1 (de) | 2006-03-30 |
| DE60208534T2 true DE60208534T2 (de) | 2006-11-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60208534T Expired - Lifetime DE60208534T2 (de) | 2001-02-08 | 2002-02-08 | Verwendung von antikörper gegen mag zur behandlung ischämischer schlaganfälle |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20040170627A1 (enExample) |
| EP (2) | EP1645285A3 (enExample) |
| JP (2) | JP5005156B2 (enExample) |
| AT (1) | ATE314861T1 (enExample) |
| AU (1) | AU2002229928A1 (enExample) |
| CY (1) | CY1105549T1 (enExample) |
| DE (1) | DE60208534T2 (enExample) |
| DK (1) | DK1357941T3 (enExample) |
| ES (1) | ES2254655T3 (enExample) |
| GB (1) | GB0103174D0 (enExample) |
| WO (1) | WO2002062383A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0103174D0 (en) * | 2001-02-08 | 2001-03-28 | Smithkline Beecham Plc | Novel method of treatment |
| US20040151721A1 (en) | 2001-10-19 | 2004-08-05 | O'keefe Theresa | Humanized anti-CCR2 antibodies and methods of use therefor |
| AR040778A1 (es) * | 2002-08-06 | 2005-04-20 | Glaxo Group Ltd | Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina). |
| GB0306309D0 (en) * | 2003-03-19 | 2003-04-23 | Glaxo Group Ltd | Method of treatment |
| US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
| MXPA05012307A (es) * | 2003-05-16 | 2006-07-03 | Acorda Therapeutics Inc | Mutantes que degradan proteoglicanos para tratamiento del snc. |
| JP2007521248A (ja) * | 2003-12-10 | 2007-08-02 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | ヒト化抗ｃｃｒ２抗体および該抗体を使用する方法 |
| CA2623635C (en) | 2005-09-26 | 2013-04-02 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase abci mutants |
| US20100189721A1 (en) * | 2007-07-06 | 2010-07-29 | Smithkline Beecham Corporation | Antibody formulations |
| US8974782B2 (en) | 2011-02-07 | 2015-03-10 | Glaxo Group Limited | Treatment of stroke comprising anti-MAG antibodies |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873316A (en) * | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US5250414A (en) * | 1988-11-04 | 1993-10-05 | Erziehungsdirektion Of The Canton Zurich | Diagnostic methods using neurite growth regulatory factors |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5154924A (en) * | 1989-09-07 | 1992-10-13 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
| US5527527A (en) * | 1989-09-07 | 1996-06-18 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
| US5182107A (en) * | 1989-09-07 | 1993-01-26 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates |
| GB9403250D0 (en) * | 1994-02-21 | 1994-04-13 | Univ Mcgill | Therapeutic use of myelin-associated glycoprotein (mag) |
| US5792743A (en) * | 1995-04-19 | 1998-08-11 | Acorda Therapeutics | Method for promoting neural growth comprising administering a soluble neural cell adhesion molecule |
| US6576607B1 (en) * | 1995-04-19 | 2003-06-10 | Acorda Therapeutics | Methods using CNS neurite outgrowth modulators |
| JP4841017B2 (ja) * | 1995-06-27 | 2011-12-21 | リサーチ ファウンデーション オブ シーユーエヌワイ， ハンター カレッジ | ミエリン会合糖タンパク質（ｍａｇ）およびそのインヒビターを用いた組成物および方法 |
| DE69818106T2 (de) * | 1997-10-28 | 2004-06-17 | The University Of British Columbia, Vancouver | Immunologische zusammensetzungen und verfahren zur transienten änderung des zentralnervensystem-myelins der saügetiere und förderung der nerven-regenerierung |
| BR9815289A (pt) * | 1997-11-14 | 2001-12-26 | Euro Celtique Sa | Imunoglobulina modificada, molécula, ácidonucleico isolado, célula contendo o mesmo, animalnão-humano recombinante, composiçãofarmacêutica, composição de vacina, processospara identificar ou medir ou detectar um antìgenode câncer, um antìgeno de um agente de doençainfecciosa, um ligante, e um receptor em umaamostra a ser testada, kits para detecção de umantìgeno de câncer, de um antìgeno de um agentede doença infecciosa, de um receptor celular paraum agente de doença infecciosa, de um ligante, e deum antìgeno de câncer, processos de diagnósticoou de exame para a presença de ou umapredisposição para desenvolvimento de um câncertipificado pela presença aumentada de umantìgeno de câncer, e para a presença de umagente de doença infecciosa, processos detratamento ou de prevenção de um câncertipificado pela presença de um antìgeno de câncer,de uma doença infecciosa tipificada pela presençade um antìgeno de agente de doença infecciosa, ede uma doença causada por um agente de doençainfecciosa que se liga em um receptor celular,processos para modulação de atividade de umprimeiro membro de um par de ligação, processo deprodução de uma imunoglobulina modificada,processo de produção de um ácido nucleicocodificador de imunoglobulina modificada, e, ácidonucleico isolado |
| WO1999053945A1 (en) * | 1998-04-16 | 1999-10-28 | Samuel David | Neuron growth inhibitory molecules or derivatives thereof used to immunize mammals thereby promoting axon regeneration |
| GB9908533D0 (en) * | 1999-04-14 | 1999-06-09 | Novartis Ag | Organic compounds |
| GB0103174D0 (en) * | 2001-02-08 | 2001-03-28 | Smithkline Beecham Plc | Novel method of treatment |
| US20040002790A1 (en) * | 2002-06-28 | 2004-01-01 | Paul Senn | Sensitive devices and sensitive applications |
| AR040778A1 (es) * | 2002-08-06 | 2005-04-20 | Glaxo Group Ltd | Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina). |
| GB0306309D0 (en) * | 2003-03-19 | 2003-04-23 | Glaxo Group Ltd | Method of treatment |
-
2001
- 2001-02-08 GB GBGB0103174.9A patent/GB0103174D0/en not_active Ceased
-
2002
- 2002-02-08 EP EP05077130A patent/EP1645285A3/en not_active Withdrawn
- 2002-02-08 AT AT02711034T patent/ATE314861T1/de active
- 2002-02-08 ES ES02711034T patent/ES2254655T3/es not_active Expired - Lifetime
- 2002-02-08 EP EP02711034A patent/EP1357941B1/en not_active Expired - Lifetime
- 2002-02-08 WO PCT/GB2002/000551 patent/WO2002062383A2/en not_active Ceased
- 2002-02-08 US US10/467,253 patent/US20040170627A1/en not_active Abandoned
- 2002-02-08 DK DK02711034T patent/DK1357941T3/da active
- 2002-02-08 JP JP2002562389A patent/JP5005156B2/ja not_active Expired - Fee Related
- 2002-02-08 DE DE60208534T patent/DE60208534T2/de not_active Expired - Lifetime
- 2002-02-08 AU AU2002229928A patent/AU2002229928A1/en not_active Abandoned
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2006
- 2006-02-01 CY CY20061100125T patent/CY1105549T1/el unknown
-
2007
- 2007-05-09 US US11/746,355 patent/US20080014195A1/en not_active Abandoned
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2008
- 2008-05-27 JP JP2008137916A patent/JP2008291031A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2254655T3 (es) | 2006-06-16 |
| JP2008291031A (ja) | 2008-12-04 |
| AU2002229928A1 (en) | 2002-08-19 |
| DK1357941T3 (da) | 2006-05-01 |
| ATE314861T1 (de) | 2006-02-15 |
| DE60208534D1 (de) | 2006-03-30 |
| CY1105549T1 (el) | 2010-07-28 |
| JP5005156B2 (ja) | 2012-08-22 |
| EP1645285A2 (en) | 2006-04-12 |
| JP2004523538A (ja) | 2004-08-05 |
| EP1357941B1 (en) | 2006-01-04 |
| WO2002062383A2 (en) | 2002-08-15 |
| EP1357941A2 (en) | 2003-11-05 |
| GB0103174D0 (en) | 2001-03-28 |
| EP1645285A3 (en) | 2010-04-14 |
| US20040170627A1 (en) | 2004-09-02 |
| WO2002062383A3 (en) | 2003-04-10 |
| US20080014195A1 (en) | 2008-01-17 |
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