DE60205338D1 - Heterocyclische verbindungen und mittel, die die hirnfunktion verbessern und als wirkstoff diese verbindungen enthalten - Google Patents
Heterocyclische verbindungen und mittel, die die hirnfunktion verbessern und als wirkstoff diese verbindungen enthaltenInfo
- Publication number
- DE60205338D1 DE60205338D1 DE60205338T DE60205338T DE60205338D1 DE 60205338 D1 DE60205338 D1 DE 60205338D1 DE 60205338 T DE60205338 T DE 60205338T DE 60205338 T DE60205338 T DE 60205338T DE 60205338 D1 DE60205338 D1 DE 60205338D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- alkyl
- agents
- improve
- chem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 239000013543 active substance Substances 0.000 title 1
- 230000003925 brain function Effects 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001022385 | 2001-01-30 | ||
| JP2001022385 | 2001-01-30 | ||
| PCT/JP2002/000694 WO2002060907A1 (fr) | 2001-01-30 | 2002-01-30 | Composes heterocycliques et compositions ameliorant les fonctions cerebrales contenant ces derniers comme principe actif |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60205338D1 true DE60205338D1 (de) | 2005-09-08 |
| DE60205338T2 DE60205338T2 (de) | 2006-06-01 |
Family
ID=18887808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60205338T Expired - Lifetime DE60205338T2 (de) | 2001-01-30 | 2002-01-30 | Heterocyclische verbindungen und mittel, die die hirnfunktion verbessern und als wirkstoff diese verbindungen enthalten |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7141579B2 (de) |
| EP (1) | EP1357124B1 (de) |
| JP (1) | JP4285994B2 (de) |
| KR (1) | KR100850818B1 (de) |
| CN (1) | CN100338074C (de) |
| AT (1) | ATE301125T1 (de) |
| AU (1) | AU2002230098B2 (de) |
| CA (1) | CA2436589C (de) |
| DE (1) | DE60205338T2 (de) |
| ES (1) | ES2247304T3 (de) |
| WO (1) | WO2002060907A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1357124B1 (de) * | 2001-01-30 | 2005-08-03 | Zenyaku Kogyo Kabushiki Kaisha | Heterocyclische verbindungen und mittel, die die hirnfunktion verbessern und als wirkstoff diese verbindungen enthalten |
| EP1791833A2 (de) * | 2004-09-24 | 2007-06-06 | Allergan, Inc. | 4-(kondensiertes cyclisches methyl)imidazol-2-thione, die als alpha2-adrenerge agonisten wirken |
| EP1797043A1 (de) * | 2004-09-24 | 2007-06-20 | Allergan, Inc. | 4-(phenylmethyl und substituiertes phenylmethyl)imidazol-2-thione, die als spezifische alpha2-adrenerge agonisten wirken |
| US7348432B2 (en) | 2004-10-27 | 2008-03-25 | Janssen Phamaceutica N.V. | Pyridine imidazoles and aza-indoles as progesterone receptor modulators |
| JP5089377B2 (ja) * | 2005-03-11 | 2012-12-05 | 全薬工業株式会社 | 複素環式化合物を有効成分とする免疫抑制剤及び抗腫瘍剤 |
| JP5160764B2 (ja) * | 2006-10-13 | 2013-03-13 | 全薬工業株式会社 | 特定の構造の複素環化合物を含む抗鬱剤、脳保護剤、アミロイドβ沈着抑制剤または老化抑制剤 |
| US20090221554A1 (en) * | 2008-02-28 | 2009-09-03 | Zenyaku Kogyo Kabushiki Kaisha | Method of treating cognitive impairment |
| CN102438992A (zh) * | 2008-12-15 | 2012-05-02 | 加利福尼亚大学董事会 | 诱导淀粉样前体蛋白裂解以形成新片段的方法 |
| EP2413929A4 (de) * | 2009-04-02 | 2012-10-10 | Zenyaku Kogyo Co Ltd | Verfahren zur behandlung von kognitiver beeinträchtigung |
| CN102395366A (zh) * | 2009-04-14 | 2012-03-28 | 金·尼古拉斯·格林 | 降低前ADAM10分泌酶和/或β分泌酶水平的方法 |
| US20100298348A1 (en) * | 2009-05-11 | 2010-11-25 | Kim Nicholas Green | Method of Decreasing Ubiquitylated Protein Levels |
| EP2808021B1 (de) * | 2012-01-25 | 2017-08-23 | Tohoku University | Mittel zur verbesserung der gehirnfunktion |
| GB201321736D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| CN106478638A (zh) * | 2016-08-31 | 2017-03-08 | 安徽省鸿鑫生物科技有限公司 | 一种2‑羟基‑7‑甲基咪唑并[1,2‑a]嘧啶的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0774205B2 (ja) * | 1986-12-04 | 1995-08-09 | 三井石油化学工業株式会社 | 新規イミダゾ−ル誘導体 |
| JPH0670064B2 (ja) | 1986-12-08 | 1994-09-07 | 三井石油化学工業株式会社 | 二環性イミダゾ−ル誘導体 |
| EP0524055A1 (de) * | 1991-07-19 | 1993-01-20 | Synthelabo | Imidazo(2,1-b)benzothiazolderivate, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung |
| US5464843A (en) | 1992-06-23 | 1995-11-07 | G.D. Searle & Co. | Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury |
| JPH0841065A (ja) | 1994-07-29 | 1996-02-13 | Sanwa Kagaku Kenkyusho Co Ltd | １−アザビシクロ［３．３．０］オクタン誘導体の製法 |
| US6114334A (en) | 1995-07-13 | 2000-09-05 | Knoll Aktiengesellschaft | Piperazine derivatives as therapeutic agents |
| CA2387719C (en) * | 1999-07-30 | 2010-04-27 | Zenyaku Kogyo Kabushiki Kaisha | Azaindolizinone derivatives and cognitive enhancers comprising the same as effective components |
| EP1357124B1 (de) * | 2001-01-30 | 2005-08-03 | Zenyaku Kogyo Kabushiki Kaisha | Heterocyclische verbindungen und mittel, die die hirnfunktion verbessern und als wirkstoff diese verbindungen enthalten |
| JP5160764B2 (ja) * | 2006-10-13 | 2013-03-13 | 全薬工業株式会社 | 特定の構造の複素環化合物を含む抗鬱剤、脳保護剤、アミロイドβ沈着抑制剤または老化抑制剤 |
| US20090221554A1 (en) * | 2008-02-28 | 2009-09-03 | Zenyaku Kogyo Kabushiki Kaisha | Method of treating cognitive impairment |
-
2002
- 2002-01-30 EP EP02711234A patent/EP1357124B1/de not_active Expired - Lifetime
- 2002-01-30 CN CNB028076257A patent/CN100338074C/zh not_active Expired - Fee Related
- 2002-01-30 AT AT02711234T patent/ATE301125T1/de not_active IP Right Cessation
- 2002-01-30 DE DE60205338T patent/DE60205338T2/de not_active Expired - Lifetime
- 2002-01-30 KR KR1020037010002A patent/KR100850818B1/ko not_active IP Right Cessation
- 2002-01-30 US US10/466,321 patent/US7141579B2/en not_active Expired - Fee Related
- 2002-01-30 ES ES02711234T patent/ES2247304T3/es not_active Expired - Lifetime
- 2002-01-30 JP JP2002561475A patent/JP4285994B2/ja not_active Expired - Lifetime
- 2002-01-30 WO PCT/JP2002/000694 patent/WO2002060907A1/ja active IP Right Grant
- 2002-01-30 CA CA2436589A patent/CA2436589C/en not_active Expired - Fee Related
- 2002-01-30 AU AU2002230098A patent/AU2002230098B2/en not_active Ceased
-
2006
- 2006-05-15 US US11/433,416 patent/US7767824B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7767824B2 (en) | 2010-08-03 |
| US20060205742A1 (en) | 2006-09-14 |
| JP4285994B2 (ja) | 2009-06-24 |
| AU2002230098B2 (en) | 2007-06-14 |
| KR20030070145A (ko) | 2003-08-27 |
| WO2002060907A1 (fr) | 2002-08-08 |
| CN1531540A (zh) | 2004-09-22 |
| CA2436589A1 (en) | 2002-08-08 |
| EP1357124A4 (de) | 2004-02-04 |
| JPWO2002060907A1 (ja) | 2004-11-11 |
| CN100338074C (zh) | 2007-09-19 |
| EP1357124A1 (de) | 2003-10-29 |
| EP1357124B1 (de) | 2005-08-03 |
| CA2436589C (en) | 2010-10-19 |
| DE60205338T2 (de) | 2006-06-01 |
| US20040048879A1 (en) | 2004-03-11 |
| ATE301125T1 (de) | 2005-08-15 |
| US7141579B2 (en) | 2006-11-28 |
| ES2247304T3 (es) | 2006-03-01 |
| KR100850818B1 (ko) | 2008-08-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |