DE60201590D1 - Antidepressiv wirksame azaheterocyclymethyl-derivative von oxaheterocycyl-anellierten (1,4)-benzodioxanen - Google Patents

Antidepressiv wirksame azaheterocyclymethyl-derivative von oxaheterocycyl-anellierten (1,4)-benzodioxanen

Info

Publication number
DE60201590D1
DE60201590D1 DE2002601590 DE60201590T DE60201590D1 DE 60201590 D1 DE60201590 D1 DE 60201590D1 DE 2002601590 DE2002601590 DE 2002601590 DE 60201590 T DE60201590 T DE 60201590T DE 60201590 D1 DE60201590 D1 DE 60201590D1
Authority
DE
Germany
Prior art keywords
oxaheterocycyl
azaheterocyclymethyl
antidepressively
anellenated
benzodioxanes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE2002601590
Other languages
English (en)
Other versions
DE60201590T2 (de
Inventor
Paul Stack
Hong Gao
Suzanne Gildersleeve
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of DE60201590D1 publication Critical patent/DE60201590D1/de
Publication of DE60201590T2 publication Critical patent/DE60201590T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE60201590T 2001-04-26 2002-04-24 Antidepressiv wirksame azaheterocyclymethyl-derivative von oxaheterocycyl-anellierten (1,4)-benzodioxanen Expired - Fee Related DE60201590T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28656901P 2001-04-26 2001-04-26
US286569P 2001-04-26
PCT/US2002/012831 WO2002088135A1 (en) 2001-04-26 2002-04-24 Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans

Publications (2)

Publication Number Publication Date
DE60201590D1 true DE60201590D1 (de) 2004-11-18
DE60201590T2 DE60201590T2 (de) 2005-02-17

Family

ID=23099201

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60201590T Expired - Fee Related DE60201590T2 (de) 2001-04-26 2002-04-24 Antidepressiv wirksame azaheterocyclymethyl-derivative von oxaheterocycyl-anellierten (1,4)-benzodioxanen

Country Status (12)

Country Link
US (1) US6552049B2 (de)
EP (1) EP1381613B1 (de)
JP (1) JP2004532236A (de)
CN (1) CN1503798A (de)
AT (1) ATE279415T1 (de)
BR (1) BR0209343A (de)
CA (1) CA2445543A1 (de)
DE (1) DE60201590T2 (de)
DK (1) DK1381613T3 (de)
ES (1) ES2229138T3 (de)
MX (1) MXPA03009825A (de)
WO (1) WO2002088135A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706736B2 (en) * 2001-04-26 2004-03-16 Wyeth Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans
US6911445B2 (en) * 2002-09-12 2005-06-28 Wyeth Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
EP2332940B1 (de) 2004-03-30 2012-10-31 Vertex Pharmaceuticals Incorporated Als Inhibitoren von JAK und anderen Proteinkinasen geeignete Azaindole
JP2005314260A (ja) * 2004-04-28 2005-11-10 Japan Science & Technology Agency フラボンｃ配糖体の製法
WO2006089053A2 (en) 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
JP5406039B2 (ja) 2006-12-21 2014-02-05 バーテックス ファーマシューティカルズ インコーポレイテッド タンパク質キナーゼ阻害剤として有用な５−シアノ−４−（ピロロ［２，３ｂ］ピリジン−３−イル）−ピリミジン誘導体
ES2604667T3 (es) 2009-06-17 2017-03-08 Vertex Pharmaceuticals Incorporated Inhibidores de la replicación de virus de influenza
CA2822057A1 (en) 2010-12-16 2012-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
MX2016006200A (es) 2013-11-13 2016-08-08 Vertex Pharma Metodos para preparar inhibidores de la replicacion de virus de influenza.
EP3068776B1 (de) 2013-11-13 2019-05-29 Vertex Pharmaceuticals Incorporated Hemmer der influenzavirenreplikation
EP3294717B1 (de) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Verfahren zur herstellung von inhibitoren der influenzavirenreplikation
EP3294735B8 (de) 2015-05-13 2022-01-05 Vertex Pharmaceuticals Incorporated Hemmer der influenzavirenreplikation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135474A1 (de) 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
DE4140540A1 (de) 1991-12-09 1993-06-17 Bayer Ag Neue azaheterocyclylmethyl-chromane
DE69433401T2 (de) 1993-08-19 2004-09-16 Janssen Pharmaceutica N.V. Gefässverengende dihydrobenzopyranderivate
US5741789A (en) 1995-01-17 1998-04-21 Eli Lilly And Company Compounds having effects on serotonin-related systems
GB9526495D0 (en) 1995-12-23 1996-02-28 Knoll Ag Therapeutic agents
US5869490A (en) 1996-10-15 1999-02-09 American Home Products Corporation Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one
DE69722020T2 (de) * 1996-10-15 2004-01-22 Wyeth Azaheterocyclylmethyl-derivate von 2,3,8,9-tetrahydro-7h-1,4-dioxino[2,3-e]indol-8-on
GB9627005D0 (en) 1996-12-27 1997-02-12 Knoll Ag Therapeutic agents
GB9704948D0 (en) 1997-03-11 1997-04-30 Knoll Ag Therapeutic agents
AU8743098A (en) * 1997-08-22 1999-03-16 Eli Lilly And Company Limited Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands
US6458802B1 (en) * 2001-03-14 2002-10-01 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline

Also Published As

Publication number Publication date
CN1503798A (zh) 2004-06-09
DK1381613T3 (da) 2005-01-24
DE60201590T2 (de) 2005-02-17
CA2445543A1 (en) 2002-11-07
EP1381613B1 (de) 2004-10-13
US20020183353A1 (en) 2002-12-05
ATE279415T1 (de) 2004-10-15
MXPA03009825A (es) 2005-03-07
WO2002088135A1 (en) 2002-11-07
BR0209343A (pt) 2004-06-15
JP2004532236A (ja) 2004-10-21
ES2229138T3 (es) 2005-04-16
US6552049B2 (en) 2003-04-22
EP1381613A1 (de) 2004-01-21

Similar Documents

Publication Publication Date Title
WO2002085896A8 (en) Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan
DE60201590D1 (de) Antidepressiv wirksame azaheterocyclymethyl-derivative von oxaheterocycyl-anellierten (1,4)-benzodioxanen
ME00039B (me) Fenil-piperazin derivati kao inhibitori resorbcije serotonina
HK1068622A1 (en) Novel heteroaryl derivatives, their preparation and use
HRP20080262T3 (en) 4-(2-phenyloxyphenyl)-piperidine or -1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors
DE60213576D1 (de) ANTIDEPRESSIVE AZAHETEROCYCLYLMETHYL-DERIVATE VON 2,3-DIHYDRO-1,4-DIOXINOi2,3-föCHINOXALIN
PT1392700E (pt) Derivados aza-heterociclilmetilo antidepressivos de 7,8-di-hidro-1,6,9-troxa-3-aza-ciclopenta(a)naftaleno
DE60206048D1 (de) Antidepressive (sssri) azaheterocyclylmethylderivate von 7,8-dihydro-3h-6,9-dioxa-1,3-diazacyclopenta [a] naphthalin
DE60201592D1 (de) ANTIDEPRESSIVE INDOLTETRAHYDROPYRIDIN-DERIVATE VON 2,3-DIHYDRO-7H[1,4]DIOXINO[2,3-e]INDOL
ATE404543T1 (de) Benzoxazocine und ihre verwendung als monoamin- wiederaufnahme inhibitoren
MXPA05010678A (es) Derivados de 4-(2-fenilsulfanil-fenil)-1,2,3,6-tetrahidropiridina como inhibidores de recaptacion de serotonina.
CA2451229A1 (en) Indole derivatives
EA200501580A1 (ru) Производные 4-(2-фенилоксифенил)пиперидина или -1,2,3,6- тетрагидропиридина в качестве ингибиторов обратного захвата серотонина
UA81472C2 (en) 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors
CA2521030A1 (en) 4-(2-phenyloxyphenyl)-piperidine or -1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee