DE602008006720D1 - Neue disubstituierte phenylpyrrolidine als modulatoren der kortikalen katecholaminergen neurotransmission - Google Patents
Neue disubstituierte phenylpyrrolidine als modulatoren der kortikalen katecholaminergen neurotransmissionInfo
- Publication number
- DE602008006720D1 DE602008006720D1 DE602008006720T DE602008006720T DE602008006720D1 DE 602008006720 D1 DE602008006720 D1 DE 602008006720D1 DE 602008006720 T DE602008006720 T DE 602008006720T DE 602008006720 T DE602008006720 T DE 602008006720T DE 602008006720 D1 DE602008006720 D1 DE 602008006720D1
- Authority
- DE
- Germany
- Prior art keywords
- catecholaminergen
- cortic
- neurotransmission
- modulators
- phenylpyrrolidines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 title 1
- 230000005062 synaptic transmission Effects 0.000 title 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000003943 catecholamines Chemical class 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 210000003710 cerebral cortex Anatomy 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 210000005171 mammalian brain Anatomy 0.000 abstract 1
- 229960002748 norepinephrine Drugs 0.000 abstract 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94199307P | 2007-06-05 | 2007-06-05 | |
| SE0701386 | 2007-06-05 | ||
| PCT/EP2008/056912 WO2008148799A1 (en) | 2007-06-05 | 2008-06-04 | New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602008006720D1 true DE602008006720D1 (de) | 2011-06-16 |
Family
ID=39672106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602008006720T Active DE602008006720D1 (de) | 2007-06-05 | 2008-06-04 | Neue disubstituierte phenylpyrrolidine als modulatoren der kortikalen katecholaminergen neurotransmission |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100197760A1 (https=) |
| EP (1) | EP2155669B1 (https=) |
| JP (1) | JP2010529080A (https=) |
| CN (1) | CN101711234A (https=) |
| AT (1) | ATE508110T1 (https=) |
| AU (1) | AU2008258597A1 (https=) |
| CA (1) | CA2689692A1 (https=) |
| DE (1) | DE602008006720D1 (https=) |
| MX (1) | MX2009012716A (https=) |
| NZ (1) | NZ581363A (https=) |
| WO (1) | WO2008148799A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008258599B2 (en) | 2007-06-05 | 2013-06-13 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission |
| EP2367787B1 (en) | 2008-11-24 | 2013-01-09 | NSAB, Filial af NeuroSearch Sweden AB, Sverige | 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission |
| CN102224135A (zh) | 2008-11-24 | 2011-10-19 | Nsab神经研究瑞典公司分公司 | 用作皮质儿茶酚胺能神经传递调节剂的新3-苯基-氮杂环丁烷衍生物 |
| CA2831435C (en) * | 2011-03-31 | 2018-05-01 | Chevron U.S.A. Inc. | Novel process and catalyst system for improving dewaxing catalyst stability and lubricant oil yield |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US364414A (en) * | 1887-06-07 | Gael hollweg | ||
| US2878264A (en) * | 1959-03-17 | Substituted amino alcohols | ||
| US3118907A (en) * | 1961-08-14 | 1964-01-21 | Mead Johnson & Co | 3-substituted-3-pyrrolidinols |
| US3647790A (en) * | 1969-04-08 | 1972-03-07 | American Home Prod | Ouinoxalinyl-oxazolidines and -oxazines |
| DE69231854T2 (de) * | 1991-04-17 | 2001-10-04 | Pharmacia & Upjohn Co., Kalamazoo | Substituierte (s)-3-phenylpiperidin derivate, deren herstellung und deren verwendung als dopamin autorezeptor antagonisten |
| US5129962A (en) * | 1991-10-22 | 1992-07-14 | International Business Machines Corporation | Tacky, no-clean thermally dissipated soldering flux |
| US20020169155A1 (en) * | 1998-09-04 | 2002-11-14 | Millennium Pharmaceuticals, Inc. | Chemokine receptor anagonists and methods of use therefor |
| SE9904723D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| SE9904724D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
| TWI308976B (en) * | 2003-02-14 | 2009-04-21 | Chunghwa Picture Tubes Ltd | Process and structure of linquid crystal panel with one drop fill |
| NZ543102A (en) * | 2003-04-24 | 2008-12-24 | Incyte Corp | Aza spiro alkane derivatives as inhibitors of metalloproteases |
| AU2004274309B2 (en) * | 2003-09-22 | 2010-04-08 | Msd K.K. | Novel piperidine derivative |
| TWI350168B (en) * | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| KR100690854B1 (ko) * | 2005-11-08 | 2007-03-09 | 엘지전자 주식회사 | 멀티태스킹이 가능한 휴대용 단말기 및 그의 멀티태스킹처리방법 |
| US8329704B2 (en) * | 2005-12-21 | 2012-12-11 | Janssen Pharmaceutica, N.V. | Substituted pyrazinone derivatives for use in MCH-1 mediated diseases |
| US20080070649A1 (en) * | 2006-09-06 | 2008-03-20 | Uchida Toshi K | Free Space Optical Interconnections in Cellular Telephone Handsets |
-
2008
- 2008-06-04 JP JP2010510782A patent/JP2010529080A/ja active Pending
- 2008-06-04 AU AU2008258597A patent/AU2008258597A1/en not_active Abandoned
- 2008-06-04 AT AT08760493T patent/ATE508110T1/de not_active IP Right Cessation
- 2008-06-04 MX MX2009012716A patent/MX2009012716A/es active IP Right Grant
- 2008-06-04 US US12/663,211 patent/US20100197760A1/en not_active Abandoned
- 2008-06-04 WO PCT/EP2008/056912 patent/WO2008148799A1/en not_active Ceased
- 2008-06-04 DE DE602008006720T patent/DE602008006720D1/de active Active
- 2008-06-04 EP EP08760493A patent/EP2155669B1/en not_active Not-in-force
- 2008-06-04 CA CA2689692A patent/CA2689692A1/en not_active Abandoned
- 2008-06-04 CN CN200880018786A patent/CN101711234A/zh active Pending
- 2008-06-04 NZ NZ581363A patent/NZ581363A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2155669B1 (en) | 2011-05-04 |
| NZ581363A (en) | 2011-10-28 |
| WO2008148799A1 (en) | 2008-12-11 |
| CN101711234A (zh) | 2010-05-19 |
| EP2155669A1 (en) | 2010-02-24 |
| US20100197760A1 (en) | 2010-08-05 |
| AU2008258597A1 (en) | 2008-12-11 |
| MX2009012716A (es) | 2009-12-14 |
| ATE508110T1 (de) | 2011-05-15 |
| CA2689692A1 (en) | 2008-12-11 |
| JP2010529080A (ja) | 2010-08-26 |
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