EA201290329A1 - Селективные гетрероциклические модуляторы рецептора сфингозин-1-фосфата - Google Patents

Селективные гетрероциклические модуляторы рецептора сфингозин-1-фосфата

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Publication number
EA201290329A1
EA201290329A1 EA201290329A EA201290329A EA201290329A1 EA 201290329 A1 EA201290329 A1 EA 201290329A1 EA 201290329 A EA201290329 A EA 201290329A EA 201290329 A EA201290329 A EA 201290329A EA 201290329 A1 EA201290329 A1 EA 201290329A1
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EA
Eurasian Patent Office
Prior art keywords
phosphate receptor
sphingozin
heterrocyclic
modulators
selective
Prior art date
Application number
EA201290329A
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English (en)
Other versions
EA025672B1 (ru
Inventor
Маркус Эф Боэм
Эстер Мартинборуг
Ингурти Брэнчмери
Маниша Мурджани
Юнко Тамийя
Лиминг Хуанг
Адам Ричард Йегер
Original Assignee
Рецептос, Инк.
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Application filed by Рецептос, Инк. filed Critical Рецептос, Инк.
Publication of EA201290329A1 publication Critical patent/EA201290329A1/ru
Publication of EA025672B1 publication Critical patent/EA025672B1/ru

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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  • Chemical & Material Sciences (AREA)
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  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Описаны соединения, которые селективно модулируют рецептор сфингозин-1-фосфата, включая соединения, которые модулируют подтип 1 рецептора S1P. Описаны способы хирального синтеза таких соединений. Описаны применения, способы лечения или профилактики и способы получения композиций по изобретению, включая соединения по изобретению для лечения или профилактики заболеваний, злокачественных состояний и нарушений, для которых медицински показано модулирование рецептора сфингозин-1-фосфата.
EA201290329A 2009-11-13 2010-11-15 Селективные гетероциклические модуляторы рецептора сфингозин-1-фосфата EA025672B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26129509P 2009-11-13 2009-11-13
US26247409P 2009-11-18 2009-11-18
PCT/US2010/056759 WO2011060391A1 (en) 2009-11-13 2010-11-15 Selective heterocyclic sphingosine 1 phosphate receptor modulators

Publications (2)

Publication Number Publication Date
EA201290329A1 true EA201290329A1 (ru) 2012-12-28
EA025672B1 EA025672B1 (ru) 2017-01-30

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US (3) US8507538B2 (ru)
EP (1) EP2498609B1 (ru)
JP (1) JP5922027B2 (ru)
KR (1) KR101771755B1 (ru)
CN (2) CN102753022B (ru)
AU (1) AU2010319982B2 (ru)
BR (1) BR112012011431A8 (ru)
CA (1) CA2780641C (ru)
DK (1) DK2498609T3 (ru)
EA (1) EA025672B1 (ru)
ES (1) ES2675799T3 (ru)
HK (1) HK1213873A1 (ru)
IL (1) IL219692A (ru)
MX (1) MX2012005559A (ru)
MY (1) MY169497A (ru)
NZ (1) NZ599914A (ru)
PT (1) PT2498609T (ru)
WO (1) WO2011060391A1 (ru)

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CN112062785B (zh) * 2019-06-11 2023-06-27 广东东阳光药业有限公司 奥扎莫德及其中间体的制备方法
US20230330077A1 (en) * 2020-09-28 2023-10-19 Lg Chem, Ltd. Use of sphingosine-1-phosphate receptor agonist
KR20220043047A (ko) * 2020-09-28 2022-04-05 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제의 용도
KR20220142379A (ko) * 2021-04-14 2022-10-21 주식회사 엘지화학 습식과립법에 의한 스핑고신-1-인산 수용체 효능제를 포함하는 경구용 고형 제제의 제조 방법
EP4321153A1 (en) * 2021-04-14 2024-02-14 Lg Chem, Ltd. Pharmaceutical composition comprising sphingosine-1-phosphate receptor agonist with controlled particle size
WO2022220595A1 (ko) * 2021-04-14 2022-10-20 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제를 포함하는 고형 제제의 제조 방법
CN117202893A (zh) * 2021-04-14 2023-12-08 株式会社Lg化学 包含鞘氨醇-1-磷酸受体激动剂的可直接压缩的药物组合物

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CA2780641C (en) 2019-03-05
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EP2498609A1 (en) 2012-09-19
EA025672B1 (ru) 2017-01-30
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PT2498609T (pt) 2018-07-06
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IL219692A (en) 2017-06-29
US20150252037A1 (en) 2015-09-10
US8507538B2 (en) 2013-08-13
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CA2780641A1 (en) 2011-05-19
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US20140039183A1 (en) 2014-02-06
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BR112012011431A8 (pt) 2017-12-26
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BR112012011431A2 (pt) 2015-10-06
CN105130922A (zh) 2015-12-09
AU2010319982A1 (en) 2012-05-31
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US20110183953A1 (en) 2011-07-28
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