DE602007014372D1 - Kristalline formen von 4-ä2-(4-methylphenylsulfany norepinephrinwiederaufnahmehemmung zur behandlung neuropathischer schmerzen - Google Patents

Kristalline formen von 4-ä2-(4-methylphenylsulfany norepinephrinwiederaufnahmehemmung zur behandlung neuropathischer schmerzen

Info

Publication number
DE602007014372D1
DE602007014372D1 DE602007014372T DE602007014372T DE602007014372D1 DE 602007014372 D1 DE602007014372 D1 DE 602007014372D1 DE 602007014372 T DE602007014372 T DE 602007014372T DE 602007014372 T DE602007014372 T DE 602007014372T DE 602007014372 D1 DE602007014372 D1 DE 602007014372D1
Authority
DE
Germany
Prior art keywords
methylphenylsulfany
treatment
neuropathic pain
crystalline forms
recovery inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007014372T
Other languages
English (en)
Inventor
Benny Bang-Andersen
Andre Faldt
Tine Bryan Stensboel
Silke Miller
De Diego Heidi Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Priority claimed from PCT/DK2007/050076 external-priority patent/WO2007144006A1/en
Publication of DE602007014372D1 publication Critical patent/DE602007014372D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/08—Malonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/12—Glutaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/08—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE602007014372T 2006-06-16 2007-06-15 Kristalline formen von 4-ä2-(4-methylphenylsulfany norepinephrinwiederaufnahmehemmung zur behandlung neuropathischer schmerzen Active DE602007014372D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80500906P 2006-06-16 2006-06-16
DKPA200600816 2006-06-16
DKPA200700423 2007-03-20
PCT/DK2007/050076 WO2007144006A1 (en) 2006-06-16 2007-06-15 Crystalline forms of 4- [2- (4-methylphenylsulfanyl) -phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain

Publications (1)

Publication Number Publication Date
DE602007014372D1 true DE602007014372D1 (de) 2011-06-16

Family

ID=39722478

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007014372T Active DE602007014372D1 (de) 2006-06-16 2007-06-15 Kristalline formen von 4-ä2-(4-methylphenylsulfany norepinephrinwiederaufnahmehemmung zur behandlung neuropathischer schmerzen

Country Status (15)

Country Link
JP (1) JP2014098017A (de)
KR (1) KR101472595B1 (de)
AR (1) AR061480A1 (de)
AT (1) ATE508115T1 (de)
BR (1) BRPI0712758A2 (de)
CA (1) CA2784304A1 (de)
DE (1) DE602007014372D1 (de)
DK (1) DK2044020T3 (de)
MY (1) MY150698A (de)
NZ (1) NZ572856A (de)
PT (1) PT2044020E (de)
RS (1) RS51687B (de)
SI (1) SI2044020T1 (de)
TN (1) TNSN08461A1 (de)
TW (1) TWI444365B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101972931B1 (ko) 2017-10-19 2019-04-26 재단법인대구경북과학기술원 풍선 타입 피질전도 측정장치 및 이의 제조방법
CN116930385B (zh) * 2023-08-08 2024-02-20 北京爱思益普生物科技股份有限公司 一种高盐浓度制剂中化合物浓度的测定方法
CN117305360B (zh) * 2023-09-15 2024-09-24 江南大学 一种哺乳动物细胞核转染液及其制备方法和在细胞核内递送的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
EA016054B1 (ru) * 2006-06-16 2012-01-30 Х. Лундбекк А/С Кристаллические формы 4-[2-(4-метилфенилсульфанил)фенил] пиперидина с объединенным ингибированием повторного поглощения серотонина и норадреналина для лечения невропатической боли

Also Published As

Publication number Publication date
MY150698A (en) 2014-02-28
JP2014098017A (ja) 2014-05-29
KR101472595B1 (ko) 2014-12-15
TWI444365B (zh) 2014-07-11
BRPI0712758A2 (pt) 2012-09-25
AR061480A1 (es) 2008-08-27
CA2784304A1 (en) 2007-12-21
TW200817329A (en) 2008-04-16
PT2044020E (pt) 2011-05-12
NZ572856A (en) 2012-02-24
RS51687B (en) 2011-10-31
TNSN08461A1 (en) 2010-04-14
ATE508115T1 (de) 2011-05-15
SI2044020T1 (sl) 2011-06-30
KR20090018630A (ko) 2009-02-20
DK2044020T3 (da) 2011-08-15

Similar Documents

Publication Publication Date Title
ATE429218T1 (de) Pinolensäure zur behandlung von übergewicht
ATE434620T1 (de) Dihydrothienopyrimidine zur behandlung von entzündlichen erkrankungen
DE602006020327D1 (de) 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3-aminder-hemmer zur behandlung thromboembolischer erkrankungen
DE602006019560D1 (de) 2-cyanobenzolsulfonamidverbindungen zur behandlung von samen
ZA200907137B (en) Novel N-(8-heteroaryltetrahydronaphtalene-2yl) or N-(5-heteroarylchromane-3-yl) carboxamide derivatives for the treatment of pain
IL193484A0 (en) Gsk-3 inhibitors for the treatment of osteoporosis
ATE490825T1 (de) Behandlung von mineralschlämmen mit verbesserter pflanzenwachstumsrehabilitation
DE502005010499D1 (de) Implantat zur Behandlung von Fettsucht
ATE493986T1 (de) Diarylharnstoffe zur behandlung von pulmonaler hypertonie
DK2117525T3 (da) Anvendelse af 1-phenyl-3-dimethylamino-propanforbindelser til behandling af neuropatismerte
ATE534633T1 (de) Indazolderivate zur behandlung von hsp90- induzierten krankheiten
ATE476414T1 (de) Biphenyloxyessigsäurederivate zur behandlung von atemwegserkrankungen
DE602006009899D1 (de) Verwendung von oxycodon zur behandlung von viszeralem schmerz
DE602007005747D1 (de) System zur Entfernung von Kalkablagerungen
DE602006009764D1 (de) Terphenylderivate zur Alzheimerbehandlung
DK2310003T3 (da) Inhibitorer af Carnitin-Palmitoyl-Transferase-1 til behandling og forebyggelse af lidelser forårsaget af delipidering af neuralt væv
ATE537178T1 (de) Neue klasse von spiro-piperidinen zur behandlung neurodegenerativer krankheiten
DE602005016141D1 (de) S-mirtazapin zur behandlung von hitzewallungen
ATE525355T1 (de) 1-ä(4-äbenzoyl(methyl)aminoü-3- (phenyl)butylüazetidinderivate zur behandlung von gastrointestinalen erkrankungen 1
DE112007001255A5 (de) Tergurid/Protergurid zur Behandlung von chronischen Schmerzen
IL210489A0 (en) Use of hdac inhibitors for the treatment of hodgkin's disease
BRPI0814409A2 (pt) Tratamento de dor neuropática
DE602007014372D1 (de) Kristalline formen von 4-ä2-(4-methylphenylsulfany norepinephrinwiederaufnahmehemmung zur behandlung neuropathischer schmerzen
ATE482707T1 (de) 1-ä2h-1-benzopyran-2-on-8-ylü- piperazin- derivate zur behandlung von schmerzen
ATE446757T1 (de) 1-ä2h-1-benzopyran-2-one-8-ylü- piperazinderivative zur behandlung von bewegungsstörungen