DE602006020246D1 - Modulatoren der glucocorticoidrezeptor-, ap-1- und/oder nf-kb-aktivität und deren verwendung - Google Patents
Modulatoren der glucocorticoidrezeptor-, ap-1- und/oder nf-kb-aktivität und deren verwendungInfo
- Publication number
- DE602006020246D1 DE602006020246D1 DE602006020246T DE602006020246T DE602006020246D1 DE 602006020246 D1 DE602006020246 D1 DE 602006020246D1 DE 602006020246 T DE602006020246 T DE 602006020246T DE 602006020246 T DE602006020246 T DE 602006020246T DE 602006020246 D1 DE602006020246 D1 DE 602006020246D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- glucocorticoid receptor
- modulators
- activity
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Virology (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64346205P | 2005-01-13 | 2005-01-13 | |
US11/330,748 US7411071B2 (en) | 2005-01-13 | 2006-01-12 | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
PCT/US2006/001329 WO2006076633A1 (en) | 2005-01-13 | 2006-01-13 | MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-κB ACTIVITY AND USE THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006020246D1 true DE602006020246D1 (de) | 2011-04-07 |
Family
ID=37983673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006020246T Active DE602006020246D1 (de) | 2005-01-13 | 2006-01-13 | Modulatoren der glucocorticoidrezeptor-, ap-1- und/oder nf-kb-aktivität und deren verwendung |
Country Status (6)
Country | Link |
---|---|
US (1) | US7411071B2 (de) |
EP (1) | EP1844028B1 (de) |
JP (1) | JP2008526994A (de) |
AT (1) | ATE499350T1 (de) |
DE (1) | DE602006020246D1 (de) |
WO (1) | WO2006076633A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7569689B2 (en) * | 2004-01-16 | 2009-08-04 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7326728B2 (en) * | 2004-01-16 | 2008-02-05 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κβ activity and use thereof |
US7273881B2 (en) * | 2004-01-16 | 2007-09-25 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7253283B2 (en) * | 2004-01-16 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7625921B2 (en) * | 2004-01-16 | 2009-12-01 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7605264B2 (en) * | 2004-01-16 | 2009-10-20 | Bristol-Myers Squibb Company | Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
EP2094692B1 (de) * | 2006-11-01 | 2012-11-28 | Bristol-Myers Squibb Company | Modulatoren des glucocorticoidrezeptors, der ap-1- und/oder der nf-kappab-aktivität und deren verwendung |
US20160331729A9 (en) | 2007-04-11 | 2016-11-17 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
US8426439B2 (en) * | 2007-04-11 | 2013-04-23 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
US11241420B2 (en) | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
US20090275529A1 (en) * | 2008-05-05 | 2009-11-05 | Reiss Allison B | Method for improving cardiovascular risk profile of cox inhibitors |
US8293776B2 (en) * | 2008-08-05 | 2012-10-23 | The Regents Of The University Of Michigan | Compositions and methods for treating inflammatory conditions of the bowel |
US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
ES2848348T3 (es) | 2014-05-16 | 2021-08-06 | Cumberland Pharmaceuticals Inc | Composiciones y métodos de tratamiento con ifetroban de la fibrosis cardíaca |
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US3422104A (en) | 1964-10-20 | 1969-01-14 | Geigy Chem Corp | 9,10-dihydro-11-amino-alkylene-9,10-ethanoanthracenes |
US3517073A (en) | 1967-06-13 | 1970-06-23 | Eastman Kodak Co | Synthesis of a hydroxy group-containing polycyclic aromatic fused ring compound |
CS198678B1 (cs) | 1978-03-17 | 1980-06-30 | Jaroslav Horyna | Způsob přípravy 9,10-dihydro-9,10-ethanoantracenových derivátů |
US4786646A (en) | 1987-07-10 | 1988-11-22 | Hoffmann-La Roche Inc. | Cyclopropylpropenamides |
EP0405436B1 (de) | 1989-06-29 | 1995-11-15 | G.D. Searle & Co. | Stickstoff enthaltende Diheterocycloheteroethanoanthracenderivate als antipsychotische Mittel |
US5055468A (en) | 1989-10-30 | 1991-10-08 | G. D. Searle & Co. | Use of bridged tricyclic amine derivatives as anti-ischemic agents |
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US5514683A (en) | 1992-02-20 | 1996-05-07 | James Black Foundation Limited | Bicyclo 2,2,2!octane derivatives |
NZ249202A (en) | 1992-02-20 | 1996-06-25 | Black James Foundation | Bicyclo[2.2.2.]octane derivatives, preparation and pharmaceutical compositions thereof |
GB9316722D0 (en) | 1993-08-12 | 1993-09-29 | Black James Foundation | Bicyclo (2.2.2)octane derivatives |
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PL375442A1 (en) | 2002-07-18 | 2005-11-28 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
US7605264B2 (en) | 2004-01-16 | 2009-10-20 | Bristol-Myers Squibb Company | Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7625921B2 (en) | 2004-01-16 | 2009-12-01 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7326728B2 (en) | 2004-01-16 | 2008-02-05 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κβ activity and use thereof |
US7569689B2 (en) | 2004-01-16 | 2009-08-04 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
-
2006
- 2006-01-12 US US11/330,748 patent/US7411071B2/en active Active
- 2006-01-13 DE DE602006020246T patent/DE602006020246D1/de active Active
- 2006-01-13 WO PCT/US2006/001329 patent/WO2006076633A1/en active Application Filing
- 2006-01-13 EP EP06718408A patent/EP1844028B1/de not_active Not-in-force
- 2006-01-13 JP JP2007551424A patent/JP2008526994A/ja active Pending
- 2006-01-13 AT AT06718408T patent/ATE499350T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2006076633A1 (en) | 2006-07-20 |
EP1844028A1 (de) | 2007-10-17 |
US7411071B2 (en) | 2008-08-12 |
US20060154975A1 (en) | 2006-07-13 |
JP2008526994A (ja) | 2008-07-24 |
EP1844028B1 (de) | 2011-02-23 |
ATE499350T1 (de) | 2011-03-15 |
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