DE602006018499D1 - Verwendung von konjugaten von doxorubicin mit lactosaminiertem albumin - Google Patents

Verwendung von konjugaten von doxorubicin mit lactosaminiertem albumin

Info

Publication number
DE602006018499D1
DE602006018499D1 DE602006018499T DE602006018499T DE602006018499D1 DE 602006018499 D1 DE602006018499 D1 DE 602006018499D1 DE 602006018499 T DE602006018499 T DE 602006018499T DE 602006018499 T DE602006018499 T DE 602006018499T DE 602006018499 D1 DE602006018499 D1 DE 602006018499D1
Authority
DE
Germany
Prior art keywords
hccs
treatment
conjugate
doxorubicin
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006018499T
Other languages
English (en)
Inventor
Luigi Fiume
Stefano Giuseppina Di
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNI DI BOLOGNA DIPARTIMENTO DI PATOLOGIA
Universita di Bologna
Original Assignee
UNI DI BOLOGNA DIPARTIMENTO DI PATOLOGIA
Universita di Bologna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNI DI BOLOGNA DIPARTIMENTO DI PATOLOGIA, Universita di Bologna filed Critical UNI DI BOLOGNA DIPARTIMENTO DI PATOLOGIA
Publication of DE602006018499D1 publication Critical patent/DE602006018499D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE602006018499T 2005-09-20 2006-09-19 Verwendung von konjugaten von doxorubicin mit lactosaminiertem albumin Active DE602006018499D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001743A ITMI20051743A1 (it) 2005-09-20 2005-09-20 Uso di coniugati della doxorubicina con albumina lattosaminata
PCT/EP2006/066489 WO2007039448A2 (en) 2005-09-20 2006-09-19 Use of conjugates of doxorubicin with lactosaminated albumin

Publications (1)

Publication Number Publication Date
DE602006018499D1 true DE602006018499D1 (de) 2011-01-05

Family

ID=37665721

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006018499T Active DE602006018499D1 (de) 2005-09-20 2006-09-19 Verwendung von konjugaten von doxorubicin mit lactosaminiertem albumin

Country Status (8)

Country Link
US (1) US20080227710A1 (de)
EP (1) EP1937310B8 (de)
CN (1) CN101267842A (de)
AT (1) ATE489139T1 (de)
DE (1) DE602006018499D1 (de)
ES (1) ES2357031T3 (de)
IT (1) ITMI20051743A1 (de)
WO (1) WO2007039448A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20040928A1 (it) 2004-05-07 2004-08-07 Uni Di Bologna Dipartiment O D Procedura per la preparazione di coniugati della doxorubicina con l'albumina umana lattosaminata
CN103656659B (zh) * 2012-09-26 2016-01-06 包骏 一种靶向载体、抗肿瘤药物及其应用
CN106344930B (zh) * 2015-07-16 2021-08-17 亚飞（上海）生物医药科技有限公司 分子定点靶向和激活的短肽阿霉素的制备和用途
RU2696096C2 (ru) * 2017-12-07 2019-07-31 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Низкомолекулярные конъюгаты противоопухолевых агентов и высокоселективных лигандов асиалогликопротеинового рецептора для терапии онкологических патологий печени
CN108671238A (zh) * 2018-05-14 2018-10-19 江苏医药职业学院 一种联合治疗高肿瘤渗透性白蛋白纳米系统的制备方法
CN109157662B (zh) * 2018-06-06 2021-07-20 北京大学 一种人血清白蛋白-阿霉素交联物纳米颗粒及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0646018A1 (de) * 1992-06-17 1995-04-05 Advanced Magnetics Incorporated Arabinogalactan derivate und ihre anwendungen
ITMI20040928A1 (it) * 2004-05-07 2004-08-07 Uni Di Bologna Dipartiment O D Procedura per la preparazione di coniugati della doxorubicina con l'albumina umana lattosaminata
KR101313712B1 (ko) * 2005-01-05 2013-10-01 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 이중 영상화 및 방사선화학요법용 접합체: 조성물,제조방법 및 적용

Also Published As

Publication number Publication date
EP1937310B1 (de) 2010-11-24
US20080227710A1 (en) 2008-09-18
WO2007039448A3 (en) 2007-05-31
EP1937310A2 (de) 2008-07-02
ITMI20051743A1 (it) 2007-03-21
ES2357031T3 (es) 2011-04-15
CN101267842A (zh) 2008-09-17
ATE489139T1 (de) 2010-12-15
EP1937310B8 (de) 2011-07-13
WO2007039448A2 (en) 2007-04-12

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