DE602005025988D1 - Zwischenprodukte für die herstellung von pramipexol - Google Patents

Zwischenprodukte für die herstellung von pramipexol

Info

Publication number
DE602005025988D1
DE602005025988D1 DE602005025988T DE602005025988T DE602005025988D1 DE 602005025988 D1 DE602005025988 D1 DE 602005025988D1 DE 602005025988 T DE602005025988 T DE 602005025988T DE 602005025988 T DE602005025988 T DE 602005025988T DE 602005025988 D1 DE602005025988 D1 DE 602005025988D1
Authority
DE
Germany
Prior art keywords
preparation
pramipexol
intermediate products
pramipexole
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602005025988T
Other languages
German (de)
English (en)
Inventor
Graziano Castaldi
Alberto Bologna
Pietro Allegrini
Gabriele Razzetti
Vittorio Lucchini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dipharma Francis SRL
Original Assignee
Dipharma Francis SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI20040531 external-priority patent/ITMI20040531A1/it
Priority claimed from ITMI20050126 external-priority patent/ITMI20050126A1/it
Application filed by Dipharma Francis SRL filed Critical Dipharma Francis SRL
Publication of DE602005025988D1 publication Critical patent/DE602005025988D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602005025988T 2004-03-19 2005-03-11 Zwischenprodukte für die herstellung von pramipexol Expired - Lifetime DE602005025988D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI20040531 ITMI20040531A1 (it) 2004-03-19 2004-03-19 Intermedi per la preparazione di pramipexolo
ITMI20050126 ITMI20050126A1 (it) 2005-01-28 2005-01-28 Intermedi per la preparazione di pramipexolo
PCT/EP2005/002641 WO2005092871A2 (en) 2004-03-19 2005-03-11 Intermediates for the preparation of pramipexole

Publications (1)

Publication Number Publication Date
DE602005025988D1 true DE602005025988D1 (de) 2011-03-03

Family

ID=34963371

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005025988T Expired - Lifetime DE602005025988D1 (de) 2004-03-19 2005-03-11 Zwischenprodukte für die herstellung von pramipexol

Country Status (8)

Country Link
US (2) US7741490B2 (https=)
EP (2) EP1730129B1 (https=)
JP (1) JP2007529446A (https=)
AT (1) ATE496036T1 (https=)
CA (1) CA2560128A1 (https=)
DE (1) DE602005025988D1 (https=)
IL (1) IL178156A0 (https=)
WO (1) WO2005092871A2 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL378587A1 (pl) * 2005-12-29 2007-07-09 Instytut Farmaceutyczny Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) * 2006-01-13 2007-07-14 Dipharma Spa Sintesi di intermedi pr la preparazione di pramipexolo
US8518926B2 (en) * 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
ES2379117T3 (es) 2006-05-16 2012-04-20 Knopp Neurosciences, Inc. Composiciones de R(+) y S(-) pramipexol y métodos de utilización de las mismas
EP1878731B1 (en) * 2006-06-26 2008-08-20 Helm AG Process for producing pramipexole
US8524695B2 (en) * 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
CA2681110A1 (en) * 2007-03-14 2008-09-18 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
GB0721332D0 (en) 2007-10-31 2007-12-12 Motac Neuroscience Ltd Medicaments
GB0721333D0 (en) * 2007-10-31 2007-12-12 Motac Neuroscience Ltd Medicaments
KR20110071064A (ko) * 2008-08-19 2011-06-28 크놉 뉴로사이언시스 인코포레이티드 (ｒ)-프라미펙솔을 사용하는 조성물 및 방법
CN101676272A (zh) * 2008-09-17 2010-03-24 北京德众万全药物技术开发有限公司 一种普拉克索的制备方法
WO2011021214A2 (en) * 2009-08-07 2011-02-24 Msn Laboratories Limited Improved process for the preparation of (s)-2-amino-4,5,6,7-tetrahydro-6 - (propylamino) benzothiazole and its pharmaceutically acceptable salts
ITMI20101998A1 (it) * 2010-10-27 2012-04-28 Dipharma Francis Srl Procedimento per la racemizzazione di acidi carbossilici
CN102442972B (zh) * 2011-10-18 2014-06-25 济南富创医药科技有限公司 一种普拉克索及其二盐酸盐一水合物的工业化制备方法
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
CN103183649A (zh) * 2011-12-31 2013-07-03 天津药物研究院 2-氨基-6-丙氨基-4,5,6,7-四氢苯并噻唑的制备方法
CN103183650A (zh) * 2011-12-31 2013-07-03 天津药物研究院 (s)-(-)2-氨基-6-丙氨基-4,5,6,7-四氢苯并噻唑的制备方法
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
EP3838271B1 (en) 2013-07-12 2025-09-03 Areteia Therapeutics, Inc. Treating elevated levels of eosinophils and/or basophils
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
ES2813674T3 (es) 2013-08-13 2021-03-24 Knopp Biosciences Llc Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b
CA2921381A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
EP4192453A4 (en) * 2020-08-05 2024-11-13 Areteia Therapeutics, Inc. USE OF DEXPRAMIPEXOLE TO TREAT MODERATE TO SEVERE ASTHMA

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3447075A1 (de) * 1984-12-22 1986-07-03 Dr. Karl Thomae Gmbh, 7950 Biberach Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
ATE45735T1 (de) 1984-12-22 1989-09-15 Thomae Gmbh Dr K Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel.
ZA864626B (en) 1985-06-24 1988-02-24 Lilly Co Eli Dialkylaminotetrahydrobenzothiazoles and oxazoles
US4988699A (en) 1989-03-14 1991-01-29 Warner-Lambert Company Substituted tetrahydrobenzothiazoles as dopaminergic agents
ID26328A (id) * 1997-12-22 2000-12-14 Bayer Ag Penghambat raf kinase menggunakan urea heterosiklik tersubstitusi aril dan heteroaril
JP2000119226A (ja) * 1998-10-13 2000-04-25 Banyu Pharmaceut Co Ltd クルチウス転移反応を固相合成に利用した新規な芳香族アミン類又は芳香族複素環アミン類の製造方法
ES2187249B1 (es) 2000-09-18 2004-09-16 Synthon Bv Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.
JP2002173476A (ja) * 2000-12-07 2002-06-21 Sumitomo Pharmaceut Co Ltd １，４−フェニレンジアミン誘導体及びその製造法
CL2004000553A1 (es) * 2003-03-20 2005-02-04 Actelion Pharmaceuticals Ltd Uso de compuestos derivados de guanidina como antagonistas del receptor de neuropeptido ff; compuestos derivados de guanidina; procedimientos de preparacion; y composicion farmaceutica que los comprende.
EP1640369A4 (en) * 2003-06-27 2007-10-31 Dainippon Sumitomo Pharma Co THIAZOLIMINE COMPOUND AND OXAZOLIMINE COMPOUND

Also Published As

Publication number Publication date
ATE496036T1 (de) 2011-02-15
JP2007529446A (ja) 2007-10-25
WO2005092871A2 (en) 2005-10-06
EP2289885A1 (en) 2011-03-02
US20100222595A1 (en) 2010-09-02
IL178156A0 (en) 2006-12-31
CA2560128A1 (en) 2005-10-06
US20070191439A1 (en) 2007-08-16
WO2005092871A3 (en) 2005-12-01
US8203002B2 (en) 2012-06-19
EP1730129A2 (en) 2006-12-13
US7741490B2 (en) 2010-06-22
EP1730129B1 (en) 2011-01-19

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