DE602005024303D1 - Verfahren zur optischen auftrennung von amlodipin - Google Patents
Verfahren zur optischen auftrennung von amlodipinInfo
- Publication number
- DE602005024303D1 DE602005024303D1 DE602005024303T DE602005024303T DE602005024303D1 DE 602005024303 D1 DE602005024303 D1 DE 602005024303D1 DE 602005024303 T DE602005024303 T DE 602005024303T DE 602005024303 T DE602005024303 T DE 602005024303T DE 602005024303 D1 DE602005024303 D1 DE 602005024303D1
- Authority
- DE
- Germany
- Prior art keywords
- amlodipine
- optically active
- amlodipin
- optical separation
- amlodipines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020040100613A KR101152608B1 (ko) | 2004-12-02 | 2004-12-02 | (ｒ,ｓ)-암로디핀으로부터 암로디핀 이성질체의 분리방법 |
| KR1020040105612A KR100760014B1 (ko) | 2004-12-14 | 2004-12-14 | 암로디핀의 광학 분리방법 |
| PCT/KR2005/004101 WO2006059886A1 (en) | 2004-12-02 | 2005-12-02 | Optical resolution method of amlodipine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005024303D1 true DE602005024303D1 (de) | 2010-12-02 |
Family
ID=36565300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005024303T Active DE602005024303D1 (de) | 2004-12-02 | 2005-12-02 | Verfahren zur optischen auftrennung von amlodipin |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7772400B2 (de) |
| EP (1) | EP1831166B1 (de) |
| JP (1) | JP5124281B2 (de) |
| AT (1) | ATE485273T1 (de) |
| AU (1) | AU2005310406B2 (de) |
| BR (1) | BRPI0519093A2 (de) |
| CA (1) | CA2589099C (de) |
| DE (1) | DE602005024303D1 (de) |
| MX (1) | MX2007006663A (de) |
| RU (1) | RU2394026C2 (de) |
| WO (1) | WO2006059886A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101235116B1 (ko) * | 2005-10-17 | 2013-02-20 | 에스케이케미칼주식회사 | 광학활성 암로디핀 겐티세이트 염의 제조방법 |
| KR100828883B1 (ko) * | 2006-10-27 | 2008-05-09 | 씨제이제일제당 (주) | 라세믹 암로디핀으로부터 ｓ-(-)-암로디핀의 분리방법 |
| KR100868160B1 (ko) * | 2007-02-14 | 2008-11-12 | 한미약품 주식회사 | Ｓ-(-)-암로디핀 또는 이의 염의 제조방법 및 이에사용되는 중간체 |
| WO2017125351A1 (en) * | 2016-01-21 | 2017-07-27 | Laboratorios Lesvi Sl | Process for preparing (( r)-3-[(-1-methylpyrrolidin-2-yl)methyl]-5-(2-phenylsulfonylethyl)-1h-indole |
| ES2886067T3 (es) | 2016-10-07 | 2021-12-16 | Silvergate Pharmaceuticals Inc | Formulaciones de amlodipina |
| US10799453B2 (en) | 2018-04-11 | 2020-10-13 | Silvergate Pharmaceuticals, Inc. | Amlodipine formulations |
| EP3560922A1 (de) * | 2018-04-24 | 2019-10-30 | Bayer Aktiengesellschaft | Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid durch racemat-spaltung mittels diastereomerer weinsäureester |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8804630D0 (en) | 1988-02-27 | 1988-03-30 | Pfizer Ltd | Preparation of r-& s-amlodipine |
| GB9405833D0 (en) * | 1994-03-24 | 1994-05-11 | Pfizer Ltd | Separation of the enantiomers of amlodipine |
| US5621140A (en) * | 1994-12-22 | 1997-04-15 | Syntex (U.S.A.) Inc. | Resolution of ibuprofen |
| CN1100038C (zh) | 2000-02-21 | 2003-01-29 | 张喜田 | 氨氯地平对映体的拆分 |
| NZ532316A (en) * | 2001-10-24 | 2005-10-28 | Sepracor Inc | Method of resolving amlodipine racemate |
| US20030176706A1 (en) | 2002-03-18 | 2003-09-18 | Joshi Rohini Ramesh | Process for the preparation of [S(-) amlodipine - L (+)- hemitartarate] |
| KR100515294B1 (ko) * | 2002-09-11 | 2005-09-15 | 한림제약(주) | 에스-(-)-암로디핀 니코티네이트 결정성 2수화물 |
| CA2525700C (en) * | 2002-09-11 | 2009-11-24 | Hanlim Pharmaceutical Co., Ltd. | S-(-)-amlodipine nicotinate and process for the preparation thereof |
| KR100476636B1 (ko) * | 2002-09-11 | 2005-03-17 | 한림제약(주) | 엘-(+)-타르트레이트를 이용한 에스-(-)-암로디핀의 제조방법 |
| US6846932B1 (en) * | 2003-11-20 | 2005-01-25 | Council Of Scientific And Industrial Research | Process for preparation of chiral amlodipine salts |
| KR101235116B1 (ko) * | 2005-10-17 | 2013-02-20 | 에스케이케미칼주식회사 | 광학활성 암로디핀 겐티세이트 염의 제조방법 |
-
2005
- 2005-12-02 JP JP2007544270A patent/JP5124281B2/ja not_active Expired - Fee Related
- 2005-12-02 BR BRPI0519093-2A patent/BRPI0519093A2/pt not_active IP Right Cessation
- 2005-12-02 CA CA2589099A patent/CA2589099C/en not_active Expired - Fee Related
- 2005-12-02 DE DE602005024303T patent/DE602005024303D1/de active Active
- 2005-12-02 EP EP05821317A patent/EP1831166B1/de active Active
- 2005-12-02 AU AU2005310406A patent/AU2005310406B2/en not_active Ceased
- 2005-12-02 MX MX2007006663A patent/MX2007006663A/es not_active Application Discontinuation
- 2005-12-02 AT AT05821317T patent/ATE485273T1/de not_active IP Right Cessation
- 2005-12-02 RU RU2007119610/04A patent/RU2394026C2/ru not_active IP Right Cessation
- 2005-12-02 US US11/792,281 patent/US7772400B2/en not_active Expired - Fee Related
- 2005-12-02 WO PCT/KR2005/004101 patent/WO2006059886A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP1831166A1 (de) | 2007-09-12 |
| CA2589099C (en) | 2014-03-25 |
| AU2005310406A2 (en) | 2006-06-08 |
| AU2005310406B2 (en) | 2012-02-02 |
| ATE485273T1 (de) | 2010-11-15 |
| MX2007006663A (es) | 2012-10-05 |
| US7772400B2 (en) | 2010-08-10 |
| BRPI0519093A2 (pt) | 2008-12-23 |
| CA2589099A1 (en) | 2006-06-08 |
| AU2005310406A1 (en) | 2006-06-08 |
| EP1831166B1 (de) | 2010-10-20 |
| RU2007119610A (ru) | 2009-01-20 |
| JP2008521887A (ja) | 2008-06-26 |
| EP1831166A4 (de) | 2009-09-02 |
| JP5124281B2 (ja) | 2013-01-23 |
| RU2394026C2 (ru) | 2010-07-10 |
| WO2006059886A1 (en) | 2006-06-08 |
| US20080249314A1 (en) | 2008-10-09 |
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