DE602005013216D1 - Mercaptoimidazole als ccr2-rezeptorantagonisten - Google Patents

Mercaptoimidazole als ccr2-rezeptorantagonisten

Info

Publication number
DE602005013216D1
DE602005013216D1 DE602005013216T DE602005013216T DE602005013216D1 DE 602005013216 D1 DE602005013216 D1 DE 602005013216D1 DE 602005013216 T DE602005013216 T DE 602005013216T DE 602005013216 T DE602005013216 T DE 602005013216T DE 602005013216 D1 DE602005013216 D1 DE 602005013216D1
Authority
DE
Germany
Prior art keywords
mercaptoimidazole
receptor antagonists
ccr2 receptor
ccr2
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602005013216T
Other languages
English (en)
Inventor
Gustaaf Maria Boeckx
Lommen Guy Van
Julien G Doyon
Erwin Coesemans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34957884&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602005013216(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE602005013216D1 publication Critical patent/DE602005013216D1/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/425—Thiazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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DE602005013216T 2004-05-26 2005-05-24 Mercaptoimidazole als ccr2-rezeptorantagonisten Expired - Fee Related DE602005013216D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2004050933 2004-05-26
PCT/EP2005/052369 WO2005118578A1 (en) 2004-05-26 2005-05-24 Mercaptoimidazoles as ccr2 receptor antagonists

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DE602005010577D1 (de) * 2004-05-26 2008-12-04 Janssen Pharmaceutica Nv Mercaptoimidazole als ccr2-rezeptorantagonisten
DK3050574T3 (da) 2015-01-28 2020-01-20 Univ Bordeaux Anvendelse af plerixafor til behandling og/eller forebyggelse af akutte forværringer af kronisk obstruktiv lungesygdom
SG11201810602YA (en) * 2016-06-03 2018-12-28 Chemocentryx Inc Method of treating liver fibrosis
EP3833762A4 (de) 2018-08-09 2022-09-28 Verseau Therapeutics, Inc. Oligonukleotidzusammensetzungen zum targeting von ccr2 und csf1r und verwendungen davon
CN113412261A (zh) * 2019-04-08 2021-09-17 四川科伦博泰生物医药股份有限公司 苯并咪唑化合物、其制备方法及其用途

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FR1487326A (fr) 1966-01-18 1967-07-07 Clin Byla Ets Dérivés imidazoliques et leur préparation
JPS5343958B2 (de) 1972-07-29 1978-11-24
US4770689A (en) * 1986-03-10 1988-09-13 Janssen Pharmaceutica N.V. Herbicidal imidazole-5-carboxylic acid derivatives
DE10107683A1 (de) 2001-02-19 2002-08-29 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
CA2463198A1 (en) * 2001-10-03 2003-04-17 Ucb, S.A. Pyrrolidinone derivatives
DE10222103A1 (de) * 2002-05-17 2003-11-27 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
WO2004069809A1 (en) 2003-02-03 2004-08-19 Janssen Pharmaceutica N.V. Mercaptoimidazoles as ccr2 receptor antagonists

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ZA200609846B (en) 2008-07-30
TW200606154A (en) 2006-02-16
EA200602193A1 (ru) 2007-04-27
CA2566187A1 (en) 2005-12-15
ATE425161T1 (de) 2009-03-15
AU2005250156A1 (en) 2005-12-15
WO2005118578A1 (en) 2005-12-15
JP2008500310A (ja) 2008-01-10
MY140571A (en) 2009-12-31
US20070249691A1 (en) 2007-10-25
EP1753758A1 (de) 2007-02-21
CN1956980A (zh) 2007-05-02
AR049386A1 (es) 2006-07-26
KR20070020070A (ko) 2007-02-16
MXPA06013764A (es) 2007-02-08
NO20066011L (no) 2007-02-23
IL179518A0 (en) 2007-05-15
EP1753758B1 (de) 2009-03-11
BRPI0511599A (pt) 2008-01-02

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