DE602005005512T2 - Antagonisten des Vanilloid-Rezeptors, insbesondere Sulfonamidderivate, welche den TRPV1-Rezeptor antagonisieren - Google Patents

Antagonisten des Vanilloid-Rezeptors, insbesondere Sulfonamidderivate, welche den TRPV1-Rezeptor antagonisieren Download PDF

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Publication number
DE602005005512T2
DE602005005512T2 DE602005005512T DE602005005512T DE602005005512T2 DE 602005005512 T2 DE602005005512 T2 DE 602005005512T2 DE 602005005512 T DE602005005512 T DE 602005005512T DE 602005005512 T DE602005005512 T DE 602005005512T DE 602005005512 T2 DE602005005512 T2 DE 602005005512T2
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DE
Germany
Prior art keywords
hydroxy
compounds
nmr
methoxy
yield
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE602005005512T
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German (de)
English (en)
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DE602005005512D1 (de
Inventor
Pier Giovanni Baraldi
Pier Andrea Borea
Pierangelo Geppetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmeste SRL
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Pharmeste SRL
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Publication of DE602005005512D1 publication Critical patent/DE602005005512D1/de
Application granted granted Critical
Publication of DE602005005512T2 publication Critical patent/DE602005005512T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/47—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE602005005512T 2004-10-26 2005-10-18 Antagonisten des Vanilloid-Rezeptors, insbesondere Sulfonamidderivate, welche den TRPV1-Rezeptor antagonisieren Expired - Lifetime DE602005005512T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT002042A ITMI20042042A1 (it) 2004-10-26 2004-10-26 Derivati solfonammidici antagonisti del recettore dei vanilloidi trpv1
ITMI20042042 2004-10-26
PCT/EP2005/011206 WO2006045498A1 (en) 2004-10-26 2005-10-18 Sulfonamido compounds that antagonise the vanilloid trpv1 receptor

Publications (2)

Publication Number Publication Date
DE602005005512D1 DE602005005512D1 (de) 2008-04-30
DE602005005512T2 true DE602005005512T2 (de) 2009-04-16

Family

ID=35501228

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005005512T Expired - Lifetime DE602005005512T2 (de) 2004-10-26 2005-10-18 Antagonisten des Vanilloid-Rezeptors, insbesondere Sulfonamidderivate, welche den TRPV1-Rezeptor antagonisieren

Country Status (8)

Country Link
US (1) US7579378B2 (enExample)
EP (1) EP1805138B1 (enExample)
JP (1) JP5080260B2 (enExample)
AT (1) ATE389634T1 (enExample)
DE (1) DE602005005512T2 (enExample)
ES (1) ES2303275T3 (enExample)
IT (1) ITMI20042042A1 (enExample)
WO (1) WO2006045498A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1861357B1 (en) * 2005-03-19 2013-04-24 Amorepacific Corporation Novel compounds or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
WO2009081222A1 (en) 2007-12-21 2009-07-02 Glenmark Pharmaceuticals, S.A. Substituted tricyclic pyridine or pyrimidine vanilloid receptor ligands
CN106146362B (zh) * 2015-04-15 2018-04-03 南京理工大学 一种合成c‑7280948的方法
CN107759477A (zh) * 2017-11-20 2018-03-06 阿里化学(常州)有限公司 一种对硝基苯乙胺盐酸盐的生产制备方法
EP4074317A1 (en) 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0693386B1 (en) 1994-07-21 1997-02-05 Nippon Paper Industries Co., Ltd. Aminobenzenesulfonamide derivatives as colour-developers for thermosensitive recording materials
ATE328868T1 (de) * 2000-08-21 2006-06-15 Pacific Corp Neue (thio)harnstoffverbindungen und arzneimittelkompositionen, die diese enthalten
DE60133743T2 (de) * 2000-08-21 2009-07-02 Pacific Corp. Neue thiourea-derivate und pharmazeutische zusammensetzungen die diese enthalten
WO2002070467A1 (en) * 2001-02-26 2002-09-12 4Sc Ag Derivatives of diphenylurea, diphenyloxalic acid diamide and diphenylsulfuric acid diamide and their use as medicaments

Also Published As

Publication number Publication date
US20090118374A1 (en) 2009-05-07
EP1805138B1 (en) 2008-03-19
WO2006045498A1 (en) 2006-05-04
ITMI20042042A1 (it) 2005-01-26
DE602005005512D1 (de) 2008-04-30
JP2008517884A (ja) 2008-05-29
EP1805138A1 (en) 2007-07-11
US7579378B2 (en) 2009-08-25
JP5080260B2 (ja) 2012-11-21
ATE389634T1 (de) 2008-04-15
ES2303275T3 (es) 2008-08-01

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