DE602004029399D1 - - Google Patents
Info
- Publication number
- DE602004029399D1 DE602004029399D1 DE602004029399T DE602004029399T DE602004029399D1 DE 602004029399 D1 DE602004029399 D1 DE 602004029399D1 DE 602004029399 T DE602004029399 T DE 602004029399T DE 602004029399 T DE602004029399 T DE 602004029399T DE 602004029399 D1 DE602004029399 D1 DE 602004029399D1
- Authority
- DE
- Germany
- Prior art keywords
- antagonists
- subject
- present
- neutralize
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55762004P | 2004-03-29 | 2004-03-29 | |
US55762104P | 2004-03-29 | 2004-03-29 | |
US55762204P | 2004-03-29 | 2004-03-29 | |
US10/842,011 US20050025763A1 (en) | 2003-05-08 | 2004-05-07 | Therapeutic use of anti-CS1 antibodies |
US10/982,357 US7709610B2 (en) | 2003-05-08 | 2004-11-05 | Therapeutic use of anti-CS1 antibodies |
PCT/US2004/037430 WO2005102387A2 (en) | 2004-03-29 | 2004-11-08 | Therapeutic use of anti-cs1 antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004029399D1 true DE602004029399D1 (de) | 2010-11-11 |
Family
ID=35197500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004029399T Active DE602004029399D1 (de) | 2004-03-29 | 2004-11-08 |
Country Status (13)
Country | Link |
---|---|
US (6) | US7709610B2 (de) |
EP (2) | EP1729803B1 (de) |
KR (1) | KR101146775B1 (de) |
CN (1) | CN1960750B (de) |
AT (1) | ATE482722T1 (de) |
AU (2) | AU2004318675B2 (de) |
BR (1) | BRPI0418695A (de) |
CA (1) | CA2561065A1 (de) |
DE (1) | DE602004029399D1 (de) |
IL (1) | IL178121A (de) |
MX (1) | MXPA06011241A (de) |
PL (1) | PL2301576T3 (de) |
WO (1) | WO2005102387A2 (de) |
Families Citing this family (66)
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US20090010920A1 (en) | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
US9051373B2 (en) | 2003-05-02 | 2015-06-09 | Xencor, Inc. | Optimized Fc variants |
US20050025763A1 (en) * | 2003-05-08 | 2005-02-03 | Protein Design Laboratories, Inc. | Therapeutic use of anti-CS1 antibodies |
US9714282B2 (en) | 2003-09-26 | 2017-07-25 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
ATE498010T1 (de) * | 2004-03-01 | 2011-02-15 | Immune Disease Inst Inc | Natürliche igm-antikörper und inhibitoren davon |
US20100136684A1 (en) * | 2004-03-01 | 2010-06-03 | Carroll Michael C | Natural IgM Antibodies |
US20150010550A1 (en) | 2004-07-15 | 2015-01-08 | Xencor, Inc. | OPTIMIZED Fc VARIANTS |
EP3299027A1 (de) | 2005-11-04 | 2018-03-28 | Genentech, Inc. | Verwendung von komplementweginhibitoren zur behandlung von augenkrankheiten |
US20080095768A1 (en) * | 2006-08-07 | 2008-04-24 | Pdl Biopharma, Inc. | Use of allogeneic effector cells and anti-cs1 antibodies for selective killing of multiple myeloma cells |
NZ574979A (en) * | 2006-08-07 | 2012-06-29 | Abbott Biotherapeutics Corp | Compositions and methods using anti-cs1 antibodies to treat multiple myeloma |
US8632772B2 (en) * | 2006-08-07 | 2014-01-21 | Dana-Farber Cancer Institute | Methods of treating multiple myeloma using combination therapies based on anti-CS1 antibodies |
CA2939806A1 (en) | 2006-11-02 | 2008-05-08 | Genentech, Inc. | Humanized anti-factor d antibodies and uses thereof |
US20100152136A1 (en) * | 2006-12-08 | 2010-06-17 | Shaughnessy Jr John D | TP53 Gene expression and uses thereof |
CR20170001A (es) | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
US9229008B2 (en) | 2008-08-19 | 2016-01-05 | Merck Sharp & Dohme Corp. | IL-8 level as a determinant of responsivity of a cancer to treatment |
US8586543B2 (en) | 2008-08-19 | 2013-11-19 | Merck Sharp & Dohme Corp. | IL-8 biomarker for monitoring cancer treatment with certain ERK inhibitors |
JP2012507555A (ja) * | 2008-10-31 | 2012-03-29 | アボット バイオセラピューティクス コーポレイション | 稀少疾患の治療における抗cs1抗体の使用 |
MX2011005910A (es) | 2008-12-04 | 2011-06-17 | Opko Curna Llc | Tratamiento de enfermedades relacionadas con eritropoyetina (epo) mediante inhibicion del transcrito antisentido natural a eritropoyetina. |
CA2765815A1 (en) | 2009-06-26 | 2010-12-29 | Opko Curna, Llc | Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene |
ES2701626T3 (es) * | 2009-12-28 | 2019-02-25 | Oncotherapy Science Inc | Anticuerpos anti-CDH3 y sus usos |
US8362210B2 (en) | 2010-01-19 | 2013-01-29 | Xencor, Inc. | Antibody variants with enhanced complement activity |
AU2011258425B2 (en) | 2010-05-27 | 2015-12-10 | Merck Sharp & Dohme Llc | Method for preparing antibodies having improved properties |
CA2834589A1 (en) | 2011-05-25 | 2012-11-29 | Merck Sharp & Dohme Corp. | Method for preparing fc-containing polypeptides having improved properties |
EA201700111A1 (ru) | 2011-10-28 | 2018-02-28 | Тева Фармасьютикал Австралия Пти Лтд | Полипептидные конструкции и их применение |
JP6403166B2 (ja) * | 2012-08-03 | 2018-10-10 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | 単一抗原抗pd−l1およびpd−l2二重結合抗体およびその使用方法 |
NO2760138T3 (de) | 2012-10-01 | 2018-08-04 | ||
JP6162319B2 (ja) | 2013-03-12 | 2017-07-12 | デシミューン セラピューティクス,インコーポレイテッド | ヒト化抗n2抗体 |
ES2951899T3 (es) * | 2013-03-15 | 2023-10-25 | Mayo Found Medical Education & Res | Identificación y monitorización de inmunoglobulinas monoclonales por masa molecular |
JP6574754B2 (ja) | 2013-03-19 | 2019-09-11 | ベイジン シェノゲン ファーマ グループ リミテッド | エストロゲン受容体関連疾患を処置するための抗体及び方法 |
CA2909952C (en) | 2013-04-29 | 2021-10-12 | Teva Pharmaceuticals Australia Pty Ltd. | Anti-cd38 antibodies and fusions to attenuated interferon alpha-2b |
US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
PL2992020T3 (pl) * | 2013-05-03 | 2020-06-01 | Ohio State Innovation Foundation | Odpornościowe komórki efektorowe wyrażające inżynierowane chimeryczne receptory antygenu swoiste dla CS1 |
MX2016001356A (es) | 2013-08-01 | 2016-10-26 | Ludwig Inst For Cancer Res Ltd | Proteina anti-garp y sus usos. |
EP2832747A1 (de) * | 2013-08-01 | 2015-02-04 | Université Catholique de Louvain | Anti-GARP-Protein und Verwendungen davon |
JP6463359B2 (ja) | 2013-08-12 | 2019-01-30 | ジェネンテック, インコーポレイテッド | 補体関連病態を治療するための組成物及び方法 |
EP3041869A1 (de) * | 2013-09-05 | 2016-07-13 | Duke University | Anti-nav1,7-antikörper und verfahren zur verwendung davon |
WO2015069703A1 (en) | 2013-11-06 | 2015-05-14 | Bristol-Myers Squibb Company | Immunotherapeutic dosing regimens and combinations thereof |
EP3066128B1 (de) | 2013-11-06 | 2018-10-31 | Bristol-Myers Squibb Company | Kombination aus anti-kir- und anti-cs1-antikörpern zur behandlung von multiplem myelom |
CN105829347B (zh) * | 2013-12-20 | 2020-09-08 | 豪夫迈·罗氏有限公司 | 双特异性her2抗体及使用方法 |
WO2015154052A1 (en) | 2014-04-04 | 2015-10-08 | Mayo Foundation For Medical Education And Research | Isotyping immunoglobulins using accurate molecular mass |
WO2015168468A1 (en) | 2014-05-01 | 2015-11-05 | Genentech, Inc. | Anti-factor d antibody variants and uses thereof |
UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
US10526391B2 (en) | 2014-07-22 | 2020-01-07 | The University Of Notre Dame Du Lac | Molecular constructs and uses thereof |
US10690676B2 (en) | 2014-07-29 | 2020-06-23 | Mayo Roundation for Medical Education and Research | Quantifying monoclonal antibody therapeutics by LC-MS/MS |
WO2016065409A1 (en) | 2014-10-29 | 2016-05-06 | Teva Pharmaceuticals Australia Pty Ltd | INTERFERON α2B VARIANTS |
US10011657B2 (en) | 2014-10-31 | 2018-07-03 | Abbvie Biotherapeutics Inc. | Anti-CS1 antibodies and antibody drug conjugates |
JP2017537927A (ja) | 2014-12-04 | 2017-12-21 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | がん(骨髄腫)を処置するための抗cs1および抗pd1抗体の併用 |
AU2016219785B2 (en) | 2015-02-20 | 2021-10-28 | Ohio State Innovation Foundation | Bivalent antibody directed against NKG2D and tumor associated antigens |
CA2990478A1 (en) | 2015-06-29 | 2017-01-05 | Bristol-Myers Squibb Company | Immunotherapeutic dosing regimens comprising pomalidomide and an anti-cs1 antibody for treating cancer |
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CN108472382A (zh) | 2015-10-30 | 2018-08-31 | 豪夫迈·罗氏有限公司 | 抗-因子d抗体变体缀合物及其用途 |
US10407510B2 (en) | 2015-10-30 | 2019-09-10 | Genentech, Inc. | Anti-factor D antibodies and conjugates |
RU2756275C2 (ru) | 2016-03-01 | 2021-09-29 | Юссум Рисёрч Девелопмент Компани Оф Зэ Хибру Юниверсити Оф Иерусалим Лтд. | Антитела, специфические к рецептору полиовируса (pvr) человека |
AU2017325022B2 (en) | 2016-09-07 | 2022-10-13 | Mayo Foundation For Medical Education And Research | Identification and monitoring of cleaved immunoglobulins by molecular mass |
EP3351271A1 (de) * | 2017-01-23 | 2018-07-25 | TheraPharm GmbH | Radioimmunkonjugate zur verwendung bei der behandlung von krankheiten im zusammenhang mit knochenmark |
GB201707561D0 (en) | 2017-05-11 | 2017-06-28 | Argenx Bvba | GARP-TGF-beta antibodies |
CN111133002A (zh) | 2017-08-07 | 2020-05-08 | 恩比伊治疗股份公司 | 具有高体内耐受性的基于蒽环类药的抗体药物缀合物 |
EP3681528A4 (de) | 2017-09-13 | 2021-07-21 | Mayo Foundation for Medical Education and Research | Identifizierung und überwachung des apoptosehemmers von makrophagen |
SG11202010493XA (en) | 2018-05-18 | 2020-11-27 | Glycotope Gmbh | Anti-muc1 antibody |
US11951131B2 (en) | 2018-07-03 | 2024-04-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-SLAMF7 chimeric antigen receptors |
KR20210116437A (ko) | 2018-11-20 | 2021-09-27 | 코넬 유니버시티 | 방사성핵종의 마크로사이클릭 복합체 및 암의 방사선 요법에서의 이의 용도 |
CN113227135A (zh) | 2018-12-28 | 2021-08-06 | 斯帕克斯治疗公司 | 用于治疗癌症和其他疾病的对紧密连接蛋白18.2具有特异性的结合分子、其组合物和方法 |
CN114729383A (zh) | 2019-07-02 | 2022-07-08 | 弗莱德哈钦森癌症研究中心 | 重组ad35载体及相关基因疗法改进 |
KR20220092578A (ko) | 2019-11-05 | 2022-07-01 | 브리스톨-마이어스 스큅 컴퍼니 | M-단백질 검정 및 이의 용도 |
KR20220143063A (ko) | 2020-02-19 | 2022-10-24 | 남미 테라퓨틱스, 인크. | 암의 치료에 유용한 TGFβ 길항제 전구약물을 함유하는 제제화된 및/또는 공동-제제화된 리포솜 조성물 및 그의 방법 |
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