DE602004027310D1 - Herstellungsverfahren zur produktion aktiver und löslicher proteine in prokaryonten und polycistronische vektoren dafür - Google Patents
Herstellungsverfahren zur produktion aktiver und löslicher proteine in prokaryonten und polycistronische vektoren dafürInfo
- Publication number
- DE602004027310D1 DE602004027310D1 DE602004027310T DE602004027310T DE602004027310D1 DE 602004027310 D1 DE602004027310 D1 DE 602004027310D1 DE 602004027310 T DE602004027310 T DE 602004027310T DE 602004027310 T DE602004027310 T DE 602004027310T DE 602004027310 D1 DE602004027310 D1 DE 602004027310D1
- Authority
- DE
- Germany
- Prior art keywords
- prokaryons
- soluble proteins
- manufacturing active
- polycistronic vectors
- vectors therefor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020040031977A KR100484653B1 (ko) | 2004-05-06 | 2004-05-06 | 원핵세포에서 활성형의 가용성 단백질을 제조하는 방법 및 이를 위한 폴리시스트론 벡터 |
PCT/KR2004/001393 WO2005108585A1 (en) | 2004-05-06 | 2004-06-11 | Preparation method for the production of active and soluble proteins in prokaryotes and polycistronic vectors therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004027310D1 true DE602004027310D1 (de) | 2010-07-01 |
Family
ID=35320239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004027310T Active DE602004027310D1 (de) | 2004-05-06 | 2004-06-11 | Herstellungsverfahren zur produktion aktiver und löslicher proteine in prokaryonten und polycistronische vektoren dafür |
Country Status (8)
Country | Link |
---|---|
US (1) | US7811786B1 (de) |
EP (1) | EP1747274B9 (de) |
JP (1) | JP4510884B2 (de) |
KR (1) | KR100484653B1 (de) |
CN (1) | CN101023174B (de) |
AT (1) | ATE468398T1 (de) |
DE (1) | DE602004027310D1 (de) |
WO (1) | WO2005108585A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2615983A1 (en) | 2005-07-21 | 2007-02-01 | Abbott Laboratories | Multiple gene expression including sorf constructs and methods with polyproteins, pro-proteins, and proteolysis |
SG193652A1 (en) | 2007-03-23 | 2013-10-30 | Wisconsin Alumni Res Found | Somatic cell reprogramming |
DK2297307T3 (en) | 2008-06-04 | 2016-07-25 | Cellular Dynamics Int Inc | PROCEDURES FOR THE MANUFACTURE OF IPS CELLS USING NON-VIRAL METHODS |
WO2010019569A1 (en) | 2008-08-12 | 2010-02-18 | Cellular Dynamics International. Inc. | Methods for the production of ips cells |
EP2501796A4 (de) * | 2009-11-18 | 2012-12-19 | Murray Goulburn Coop Co Ltd | Rekombinante mikroorganismen |
GB201018664D0 (en) * | 2010-11-05 | 2010-12-22 | Msd Biolog Uk Ltd | Expression process |
CN102329811B (zh) * | 2011-09-15 | 2014-08-13 | 生工生物工程(上海)股份有限公司 | 一种氨苄青霉素抗性质粒载体及其制备与应用 |
HUP1200171A1 (hu) * | 2012-03-19 | 2013-09-30 | Richter Gedeon Nyrt | Módszerek polipeptidek elõállítására |
KR101477235B1 (ko) | 2012-09-28 | 2015-01-02 | 선문대학교 산학협력단 | 합성생물학에서 사용되는 멀티-모노시스트로닉 벡터의 제작과 응용 |
WO2014082080A2 (en) * | 2012-11-26 | 2014-05-30 | Callidus Biopharma, Inc. | Methods for coupling targeting peptides onto recombinant lysosomal enzymes for improved treatments of lysosomal storage diseases |
US11034966B2 (en) * | 2014-08-28 | 2021-06-15 | Synthetic Biologics, Inc. | E. coli-based production of beta-lactamase |
CN104946647A (zh) * | 2015-06-08 | 2015-09-30 | 南京理工大学 | 一种莱茵衣藻基因间表达处理元件 |
CN105420263B (zh) * | 2015-12-16 | 2019-07-26 | 温州医科大学 | 重组人成纤维细胞生长因子-17的生产方法 |
CN106434733B (zh) * | 2016-08-01 | 2019-09-27 | 江南大学 | 一种适用于谷氨酸棒杆菌的表达载体及其应用 |
JP7083124B2 (ja) | 2017-04-25 | 2022-06-10 | 国立大学法人弘前大学 | ムコン酸産生形質転換微生物及びその利用 |
CN110945123B (zh) * | 2017-06-23 | 2023-06-23 | 珠海亿胜生物制药有限公司 | 生产可溶性重组人碱性成纤维细胞生长因子(rh-bFGF)的方法 |
WO2018232750A1 (zh) * | 2017-06-23 | 2018-12-27 | 珠海亿胜生物制药有限公司 | 重组人碱性成纤维细胞生长因子(rh-bFGF)以及包含rh-bFGF的药物组合物 |
KR102440312B1 (ko) * | 2020-08-28 | 2022-09-05 | 한국해양과학기술원 | 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL80511A0 (en) | 1985-11-05 | 1987-02-27 | Genetics Inst | Multiply amplifiable vectors for high level expression of exogenous dna |
JP2570651B2 (ja) * | 1986-10-09 | 1997-01-08 | 藤沢薬品工業株式会社 | Met−インスリン様成長因子Iの製造方法 |
US5648254A (en) * | 1988-01-15 | 1997-07-15 | Zymogenetics, Inc. | Co-expression in eukaryotic cells |
AU2660397A (en) | 1996-04-05 | 1997-10-29 | Board Of Regents, The University Of Texas System | Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells |
KR100203919B1 (ko) | 1996-10-04 | 1999-06-15 | 신동권 | 수용성 단백질을 생산하는 새로운 발현 플라스미드 |
KR100254063B1 (ko) | 1997-09-30 | 2000-04-15 | 신동권 | 재조합대장균을이용한재조합단백질의제조방법 |
ATE463580T1 (de) | 2000-12-26 | 2010-04-15 | Sekisui Chemical Co Ltd | Verfahren zur herstellung von rekombinantem protein und fusionsprotein |
SI1368483T1 (sl) * | 2001-03-09 | 2013-01-31 | Genentech, Inc. | Postopek za pripravo polipeptidov |
KR20040007892A (ko) | 2002-07-11 | 2004-01-28 | 주식회사 바이오프로젠 | 재조합 인간 훼리틴 단백질 및 그 제조방법 |
-
2004
- 2004-05-06 KR KR1020040031977A patent/KR100484653B1/ko active IP Right Grant
- 2004-06-11 WO PCT/KR2004/001393 patent/WO2005108585A1/en active Application Filing
- 2004-06-11 DE DE602004027310T patent/DE602004027310D1/de active Active
- 2004-06-11 JP JP2007511267A patent/JP4510884B2/ja active Active
- 2004-06-11 CN CN200480043539XA patent/CN101023174B/zh active Active
- 2004-06-11 US US11/579,753 patent/US7811786B1/en active Active
- 2004-06-11 AT AT04736706T patent/ATE468398T1/de not_active IP Right Cessation
- 2004-06-11 EP EP04736706A patent/EP1747274B9/de active Active
Also Published As
Publication number | Publication date |
---|---|
EP1747274A1 (de) | 2007-01-31 |
US7811786B1 (en) | 2010-10-12 |
JP2007535923A (ja) | 2007-12-13 |
CN101023174A (zh) | 2007-08-22 |
EP1747274B9 (de) | 2011-02-02 |
EP1747274B1 (de) | 2010-05-19 |
CN101023174B (zh) | 2011-03-02 |
WO2005108585A1 (en) | 2005-11-17 |
EP1747274A4 (de) | 2007-07-11 |
JP4510884B2 (ja) | 2010-07-28 |
ATE468398T1 (de) | 2010-06-15 |
KR100484653B1 (ko) | 2005-04-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |