DE602004025747D1 - Zweiphasiges verfahren zur synthese ausgewählter pyrazolopyrimidine - Google Patents

Zweiphasiges verfahren zur synthese ausgewählter pyrazolopyrimidine

Info

Publication number
DE602004025747D1
DE602004025747D1 DE602004025747T DE602004025747T DE602004025747D1 DE 602004025747 D1 DE602004025747 D1 DE 602004025747D1 DE 602004025747 T DE602004025747 T DE 602004025747T DE 602004025747 T DE602004025747 T DE 602004025747T DE 602004025747 D1 DE602004025747 D1 DE 602004025747D1
Authority
DE
Germany
Prior art keywords
pyrazolopyrimidines
substituted
pyrimidin
phenyl
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004025747T
Other languages
English (en)
Inventor
Gary Lee Cantrell
Frank William Moser
Robert Edward Halvachs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of DE602004025747D1 publication Critical patent/DE602004025747D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602004025747T 2004-01-14 2004-12-02 Zweiphasiges verfahren zur synthese ausgewählter pyrazolopyrimidine Active DE602004025747D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53630204P 2004-01-14 2004-01-14
PCT/US2004/040241 WO2005070931A1 (en) 2004-01-14 2004-12-02 Two-phase method for the synthesis of selected pyrazolopyrimidines

Publications (1)

Publication Number Publication Date
DE602004025747D1 true DE602004025747D1 (de) 2010-04-08

Family

ID=34806998

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004025747T Active DE602004025747D1 (de) 2004-01-14 2004-12-02 Zweiphasiges verfahren zur synthese ausgewählter pyrazolopyrimidine

Country Status (10)

Country Link
US (1) US7498434B2 (de)
EP (1) EP1713808B1 (de)
JP (1) JP2007517876A (de)
CN (1) CN1906197A (de)
AT (1) ATE458739T1 (de)
AU (1) AU2004314335A1 (de)
CA (1) CA2553465A1 (de)
DE (1) DE602004025747D1 (de)
ES (1) ES2338659T3 (de)
WO (1) WO2005070931A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005099712A2 (en) * 2004-04-19 2005-10-27 Sanmar Speciality Chemicals Limited Process for preparation of n-[3-(3-cyanopyrazolo [1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide
WO2006070244A2 (en) * 2004-11-22 2006-07-06 Bakulesh Mafatlal Khamar A process for the preparation of zaleplon
CN102816163A (zh) * 2012-08-20 2012-12-12 四川禾邦阳光制药股份有限公司 扎来普隆的新晶型及制备方法
WO2022084741A1 (en) 2020-10-23 2022-04-28 Ildong Pharmaceutical Co., Ltd. Cftr modulator compounds, compositions, and uses thereof
CN112939987B (zh) * 2021-02-18 2022-03-22 新乡医学院 一种茚地普隆中间体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US5714607A (en) * 1995-12-01 1998-02-03 American Cyanamid Company Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide
US6399621B1 (en) * 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
US6472528B1 (en) 1999-08-10 2002-10-29 Neurocrine Biosciences, Inc. Synthesis of substituted pyrazolopyrimidines
AR029780A1 (es) * 2000-12-13 2003-07-16 Gador Sa Procedimiento mejorado para la obtencion de n-[3(3-ciano-pirazolo[1,5-a]pirimidin-7-il)fenil]-n-etil-acetamida
DE02778962T1 (de) * 2001-06-12 2005-02-10 Biogal Gyogyszergyar Rt. VERFAHREN ZUR HERSTELLUNG VON N ç3 (3 CYANOPYRAZOLOç1,5 A!PYRIMIDIN 7 YL)PHENYL!-N-ETHYLACETAMID (ZALEPLON)
SK472004A3 (en) * 2001-08-01 2004-12-01 Biogal Gyogyszergyar Purification and crystalline forms of zaleplon

Also Published As

Publication number Publication date
US7498434B2 (en) 2009-03-03
CN1906197A (zh) 2007-01-31
ATE458739T1 (de) 2010-03-15
JP2007517876A (ja) 2007-07-05
CA2553465A1 (en) 2005-08-04
ES2338659T3 (es) 2010-05-11
EP1713808A1 (de) 2006-10-25
EP1713808B1 (de) 2010-02-24
WO2005070931A1 (en) 2005-08-04
US20070155995A1 (en) 2007-07-05
AU2004314335A1 (en) 2005-08-04

Similar Documents

Publication Publication Date Title
CA2191647A1 (en) Process improvement in the synthesis of n-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide
CO5660266A2 (es) Sal de acido fosforico de un inhibidor de la dipeptidil peptidasa-iv
CA2493359A1 (en) Novel polymorph of n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-.alpha.]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
WO2007012953A3 (en) Pyrrolo[2,3-d]pyrimidine derivatives; their intermediates and synthesis
ATE477255T1 (de) Imidazobenzdiazepinderivate
ATE458739T1 (de) Zweiphasiges verfahren zur synthese ausgewählter pyrazolopyrimidine
WO2005103052A8 (en) Pyrazolo [1,5-a] pyrimidin-7-one compounds and uses thereof
HUP0402257A2 (hu) Eljárás az N-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)-fenil]-N-etil-acetamid (zaleplon) előállítására
IL160076A0 (en) Process for purifying n-[3-(3-cyanopyrazolo{1,5-a} pyrimidin-7-yl) phenyl]-n-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process
DE60019350D1 (de) Synthese substituierter Pyrazolopyrimidine
ES533654A0 (es) Procedimiento para preparar pirazol (1,5-a)pirimidin-metanonas
IL177856A0 (en) 2-pyridinyl[7-(substituted-pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
Rahmati One-pot synthesis of 2-alkyl-7-amino-5-aryl-pyrazolo [1, 5-a] pyrimidine-6-carbonitriles via a domino three-component condensation-oxidation reaction
CA2417875A1 (en) Polymorphs of zaleplon and methods for the preparation thereof
GB9828340D0 (en) Organic compounds
WO2005099712A3 (en) Process for preparation of n-[3-(3-cyanopyrazolo [1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide
DE60309159D1 (de) Verfahren zur herstellung von zaleplon
WO2006070244A3 (en) A process for the preparation of zaleplon
PT2081935T (pt) Polimorfo b de n-{2-fluoro-5-3-(tiofeno-2-carbonil)- pirazolo[1,5-a] pirimidin-7-il]-fenil}-n-metil-acetamida
ATE368667T1 (de) Verfahren zur herstellung von n-ethyl-n-(3-(3- cyanopyrazolo-(1,5-a)-pyrimidin-7-yl)phenyl)- acetamid
IL187975A0 (en) Method for production of substituted phenylmalonate esters intermediate compounds and the use thereof for the production of 5,7-dihydroxy-6-(2,4,6-trifluorophenyl)-(1,2,4)triazolo(1,5-a)pyrimidines
EP1344768B1 (de) Synthese substituierter Pyrazolopyrimidine
CA2550874A1 (en) Process for the preparation of triazolopyrimidines
UA127984U (uk) СПОСІБ ОДЕРЖАННЯ АНЕЛЬОВАНИХ [1,2,3]ТРИАЗОЛО-[1,5-a]ПІРИМІДИН-3-ІЛ)МЕТИЛЕН)МАЛОНОНІТРИЛІВ
Naik et al. Novel process for the synthesis of Zaleplon

Legal Events

Date Code Title Description
8364 No opposition during term of opposition