DE602004023105D1 - HERSTELLUNG VON 4,5-DIALKYL-3-ACYLPYRROL-2-CARBONS ANSCHLIEßENDE ACYLIERUNG - Google Patents
HERSTELLUNG VON 4,5-DIALKYL-3-ACYLPYRROL-2-CARBONS ANSCHLIEßENDE ACYLIERUNGInfo
- Publication number
- DE602004023105D1 DE602004023105D1 DE602004023105T DE602004023105T DE602004023105D1 DE 602004023105 D1 DE602004023105 D1 DE 602004023105D1 DE 602004023105 T DE602004023105 T DE 602004023105T DE 602004023105 T DE602004023105 T DE 602004023105T DE 602004023105 D1 DE602004023105 D1 DE 602004023105D1
- Authority
- DE
- Germany
- Prior art keywords
- acylpyrrol
- acylation
- dialkyl
- preparation
- carbon connecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000010933 acylation Effects 0.000 title 1
- 238000005917 acylation reaction Methods 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 title 1
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51528303P | 2003-10-28 | 2003-10-28 | |
| PCT/US2004/037985 WO2005042484A1 (en) | 2003-10-28 | 2004-10-28 | Preparation of 4,5-dialkyl-3-acyl-pyrrole-2-carboxylic acid derivatives by fischer-fink type synthesis and subsequent acylation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004023105D1 true DE602004023105D1 (de) | 2009-10-22 |
Family
ID=34549387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004023105T Expired - Lifetime DE602004023105D1 (de) | 2003-10-28 | 2004-10-28 | HERSTELLUNG VON 4,5-DIALKYL-3-ACYLPYRROL-2-CARBONS ANSCHLIEßENDE ACYLIERUNG |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7250520B2 (https=) |
| EP (1) | EP1678134B1 (https=) |
| JP (2) | JP4942485B2 (https=) |
| KR (1) | KR20060122872A (https=) |
| CN (1) | CN1894211A (https=) |
| AT (1) | ATE442355T1 (https=) |
| AU (1) | AU2004285972A1 (https=) |
| DE (1) | DE602004023105D1 (https=) |
| ES (1) | ES2330944T3 (https=) |
| IL (1) | IL175253A0 (https=) |
| WO (1) | WO2005042484A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP1019A (en) | 1996-10-18 | 2001-10-16 | Vertex Pharma | Inhibitors of serinre proteases, particularly hepatitis C virus NS3 protease. |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| UY28500A1 (es) | 2003-09-05 | 2005-04-29 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc. |
| US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
| US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| AU2007217355B2 (en) | 2006-02-27 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Co-crystals comprising VX-950 and pharmaceutical compositions comprising the same |
| WO2007109080A2 (en) | 2006-03-16 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis c protease inhibitors |
| WO2008106058A2 (en) | 2007-02-27 | 2008-09-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| HRP20120330T1 (hr) | 2007-02-27 | 2012-05-31 | Vertex Pharmaceuticals Incorporated | Sukristali i farmaceutski pripravci koji ih sadrže |
| NZ583699A (en) | 2007-08-30 | 2012-04-27 | Vertex Pharma | Co-crystals of vx-950 (telaprevir) other components and pharmaceutical compositions comprising the same |
| EP2489346A1 (en) | 2011-01-26 | 2012-08-22 | NanotecMARIN GmbH | Food supplement and injectable material for prophylaxis and therapy of osteoporosis and other bone diseases |
| JP2015053226A (ja) | 2013-09-09 | 2015-03-19 | タイコエレクトロニクスジャパン合同会社 | 電気コネクタの端子、及び電気コネクタ |
| US10207974B1 (en) | 2017-12-05 | 2019-02-19 | Chevron Phillips Chemical Company Lp | Synthesis of gamma dicarbonyl and pyrrole compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003223602B8 (en) * | 2002-04-11 | 2010-05-27 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis C virus NS3-NS4 protease |
| WO2004092161A1 (en) * | 2003-04-11 | 2004-10-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
-
2004
- 2004-10-28 WO PCT/US2004/037985 patent/WO2005042484A1/en not_active Ceased
- 2004-10-28 US US10/978,301 patent/US7250520B2/en not_active Expired - Fee Related
- 2004-10-28 KR KR1020067010241A patent/KR20060122872A/ko not_active Abandoned
- 2004-10-28 EP EP04796917A patent/EP1678134B1/en not_active Expired - Lifetime
- 2004-10-28 DE DE602004023105T patent/DE602004023105D1/de not_active Expired - Lifetime
- 2004-10-28 ES ES04796917T patent/ES2330944T3/es not_active Expired - Lifetime
- 2004-10-28 AU AU2004285972A patent/AU2004285972A1/en not_active Abandoned
- 2004-10-28 JP JP2006538556A patent/JP4942485B2/ja not_active Expired - Fee Related
- 2004-10-28 AT AT04796917T patent/ATE442355T1/de not_active IP Right Cessation
- 2004-10-28 CN CNA2004800377619A patent/CN1894211A/zh active Pending
-
2006
- 2006-04-27 IL IL175253A patent/IL175253A0/en unknown
-
2007
- 2007-06-13 US US11/762,274 patent/US20080167480A1/en not_active Abandoned
-
2011
- 2011-06-14 JP JP2011131818A patent/JP2011231117A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004285972A1 (en) | 2005-05-12 |
| US20050143585A1 (en) | 2005-06-30 |
| JP2007509991A (ja) | 2007-04-19 |
| ES2330944T3 (es) | 2009-12-17 |
| JP4942485B2 (ja) | 2012-05-30 |
| HK1092134A1 (en) | 2007-02-02 |
| CN1894211A (zh) | 2007-01-10 |
| WO2005042484A1 (en) | 2005-05-12 |
| US20080167480A1 (en) | 2008-07-10 |
| KR20060122872A (ko) | 2006-11-30 |
| IL175253A0 (en) | 2006-09-05 |
| EP1678134B1 (en) | 2009-09-09 |
| ATE442355T1 (de) | 2009-09-15 |
| JP2011231117A (ja) | 2011-11-17 |
| EP1678134A1 (en) | 2006-07-12 |
| US7250520B2 (en) | 2007-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |