DE602004020359D1 - Tocopherolderivate mit einer langen hydroxylierten kette, die sich als neurotrophe mittel einsetzen lassen - Google Patents

Tocopherolderivate mit einer langen hydroxylierten kette, die sich als neurotrophe mittel einsetzen lassen

Info

Publication number
DE602004020359D1
DE602004020359D1 DE602004020359T DE602004020359T DE602004020359D1 DE 602004020359 D1 DE602004020359 D1 DE 602004020359D1 DE 602004020359 T DE602004020359 T DE 602004020359T DE 602004020359 T DE602004020359 T DE 602004020359T DE 602004020359 D1 DE602004020359 D1 DE 602004020359D1
Authority
DE
Germany
Prior art keywords
compounds
long
differentiation
diseases
promote
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004020359T
Other languages
English (en)
Inventor
Bang Luu
Paul Heuschling
Thierry Muller
Eleonora Morga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite de Strasbourg
Universite du Luxembourg
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite Louis Pasteur Strasbourg I
Universite du Luxembourg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite Louis Pasteur Strasbourg I, Universite du Luxembourg filed Critical Centre National de la Recherche Scientifique CNRS
Publication of DE602004020359D1 publication Critical patent/DE602004020359D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DE602004020359T 2003-09-26 2004-09-24 Tocopherolderivate mit einer langen hydroxylierten kette, die sich als neurotrophe mittel einsetzen lassen Active DE602004020359D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0311325A FR2860233B1 (fr) 2003-09-26 2003-09-26 Composes promoteurs de la differenciation des precurseurs d'oligodendrocytes et modulateurs de l'activation microgliale, compositions et utilisations.
PCT/FR2004/002424 WO2005030748A1 (fr) 2003-09-26 2004-09-24 Derives de tocopherol a longue chaine hydroxylee utiles comme neurotrophiques

Publications (1)

Publication Number Publication Date
DE602004020359D1 true DE602004020359D1 (de) 2009-05-14

Family

ID=34307210

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004020359T Active DE602004020359D1 (de) 2003-09-26 2004-09-24 Tocopherolderivate mit einer langen hydroxylierten kette, die sich als neurotrophe mittel einsetzen lassen

Country Status (17)

Country Link
US (1) US7691900B2 (de)
EP (1) EP1664012B1 (de)
JP (1) JP2007506714A (de)
CN (1) CN100519546C (de)
AT (1) ATE427307T1 (de)
AU (1) AU2004276040B2 (de)
CA (1) CA2536791A1 (de)
CY (1) CY1110470T1 (de)
DE (1) DE602004020359D1 (de)
DK (1) DK1664012T3 (de)
ES (1) ES2324616T3 (de)
FR (1) FR2860233B1 (de)
HK (1) HK1092400A1 (de)
PL (1) PL1664012T3 (de)
PT (1) PT1664012E (de)
SI (1) SI1664012T1 (de)
WO (1) WO2005030748A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2898124B1 (fr) * 2006-03-03 2008-09-12 Centre Nat Rech Scient Derive de resveratol a longue chaine hydroxylee utiles comme neurotrophiques
EP2042172A1 (de) * 2007-09-26 2009-04-01 Inserm Verwendung von Tocopherol-Derivaten als Inhibitoren des Notch-Signalweges
WO2009046377A2 (en) * 2007-10-04 2009-04-09 Medistem Laboratories, Inc. Compositions and methods of stem cell therapy for autism
EP2112145A1 (de) 2008-04-24 2009-10-28 AxoGlia Therapeutics S.A. Chromenonderivate zur Behandlung von neurodegenerativen Krankheiten
LU91562B1 (en) * 2009-05-04 2010-11-05 Axoglia Therapeutics S A Hydroquinone derivatives.
FR2949196B1 (fr) * 2009-08-21 2013-01-11 Oreal Procede de coloration capillaire mettant en oeuvre un colorant chromenique ou chromanique

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08768B2 (ja) * 1989-08-24 1996-01-10 武田薬品工業株式会社 神経成長因子分泌誘導剤
JP3150740B2 (ja) * 1991-12-26 2001-03-26 エーザイ株式会社 ジヒドロベンゾフラン誘導体
DE69200126D1 (de) 1992-11-18 1994-07-07 Medafor Illkirch Graffenstaden Langkettige Fettalkohole mit neurotropischer und gedächtnissfördernder Wirkung.
JP2000229998A (ja) * 1998-12-08 2000-08-22 Fujisawa Pharmaceut Co Ltd 新規化合物
JP4469441B2 (ja) * 1999-02-10 2010-05-26 明治乳業株式会社 神経変性疾患の予防又は治療薬
JP4354585B2 (ja) * 1999-09-22 2009-10-28 明治乳業株式会社 シクロヘキセノール誘導体及びこれを含有する医薬
US20020006954A1 (en) * 2000-03-02 2002-01-17 Oklahoma Medical Research Foundation Desmethyl tocopherols for preventing or slowing degenerative neurological diseases
JP4745491B2 (ja) * 2000-10-11 2011-08-10 株式会社明治 インドール長鎖アルコール及びこれを含有する医薬
JP2002332283A (ja) * 2001-03-09 2002-11-22 Kuraray Co Ltd クロマン誘導体及びその製造方法
WO2003068741A1 (en) 2002-02-13 2003-08-21 Meiji Dairies Corporation Indole derivatives substituted with long-chain alcohols and medicaments containing them

Also Published As

Publication number Publication date
CY1110470T1 (el) 2015-04-29
EP1664012B1 (de) 2009-04-01
EP1664012A1 (de) 2006-06-07
CA2536791A1 (fr) 2005-04-07
US7691900B2 (en) 2010-04-06
WO2005030748A1 (fr) 2005-04-07
ATE427307T1 (de) 2009-04-15
FR2860233B1 (fr) 2007-10-19
FR2860233A1 (fr) 2005-04-01
SI1664012T1 (sl) 2009-08-31
AU2004276040A1 (en) 2005-04-07
JP2007506714A (ja) 2007-03-22
ES2324616T3 (es) 2009-08-11
PL1664012T3 (pl) 2010-01-29
DK1664012T3 (da) 2009-07-27
AU2004276040B2 (en) 2009-04-23
CN1849312A (zh) 2006-10-18
PT1664012E (pt) 2009-07-07
US20070105946A1 (en) 2007-05-10
CN100519546C (zh) 2009-07-29
HK1092400A1 (en) 2007-02-09

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: UNIVERSITE DE STRASBOURG, STRASBOURG, FR

Owner name: UNIVERSITE DU LUXEMBOURG, LUXEMBOURG-LIMPERTSB, LU

Owner name: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (, FR

8364 No opposition during term of opposition