PT1664012E - Derivados de tocoferol com cadeia hidroxilada longa úteis como neurotróficos - Google Patents

Derivados de tocoferol com cadeia hidroxilada longa úteis como neurotróficos Download PDF

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Publication number
PT1664012E
PT1664012E PT04787448T PT04787448T PT1664012E PT 1664012 E PT1664012 E PT 1664012E PT 04787448 T PT04787448 T PT 04787448T PT 04787448 T PT04787448 T PT 04787448T PT 1664012 E PT1664012 E PT 1664012E
Authority
PT
Portugal
Prior art keywords
compounds
neurotrophics
long
differentiation
diseases
Prior art date
Application number
PT04787448T
Other languages
English (en)
Inventor
Bang Luu
Paul Heuschling
Thierry Muller
Eleonora Morga
Original Assignee
Centre Nat Rech Scient
Univ Luxembourg
Univ Strasbourg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Univ Luxembourg, Univ Strasbourg filed Critical Centre Nat Rech Scient
Publication of PT1664012E publication Critical patent/PT1664012E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT04787448T 2003-09-26 2004-09-24 Derivados de tocoferol com cadeia hidroxilada longa úteis como neurotróficos PT1664012E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0311325A FR2860233B1 (fr) 2003-09-26 2003-09-26 Composes promoteurs de la differenciation des precurseurs d'oligodendrocytes et modulateurs de l'activation microgliale, compositions et utilisations.

Publications (1)

Publication Number Publication Date
PT1664012E true PT1664012E (pt) 2009-07-07

Family

ID=34307210

Family Applications (1)

Application Number Title Priority Date Filing Date
PT04787448T PT1664012E (pt) 2003-09-26 2004-09-24 Derivados de tocoferol com cadeia hidroxilada longa úteis como neurotróficos

Country Status (17)

Country Link
US (1) US7691900B2 (pt)
EP (1) EP1664012B1 (pt)
JP (1) JP2007506714A (pt)
CN (1) CN100519546C (pt)
AT (1) ATE427307T1 (pt)
AU (1) AU2004276040B2 (pt)
CA (1) CA2536791A1 (pt)
CY (1) CY1110470T1 (pt)
DE (1) DE602004020359D1 (pt)
DK (1) DK1664012T3 (pt)
ES (1) ES2324616T3 (pt)
FR (1) FR2860233B1 (pt)
HK (1) HK1092400A1 (pt)
PL (1) PL1664012T3 (pt)
PT (1) PT1664012E (pt)
SI (1) SI1664012T1 (pt)
WO (1) WO2005030748A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2898124B1 (fr) * 2006-03-03 2008-09-12 Centre Nat Rech Scient Derive de resveratol a longue chaine hydroxylee utiles comme neurotrophiques
EP2042172A1 (en) * 2007-09-26 2009-04-01 Inserm Use of tocopherol derivatives as inhibitors of the notch signalling pathway
WO2009046377A2 (en) * 2007-10-04 2009-04-09 Medistem Laboratories, Inc. Compositions and methods of stem cell therapy for autism
EP2112145A1 (en) 2008-04-24 2009-10-28 AxoGlia Therapeutics S.A. Chromenone derivatives useful for the treatment of neurodegenerative diseases
LU91562B1 (en) * 2009-05-04 2010-11-05 Axoglia Therapeutics S A Hydroquinone derivatives.
FR2949196B1 (fr) * 2009-08-21 2013-01-11 Oreal Procede de coloration capillaire mettant en oeuvre un colorant chromenique ou chromanique

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08768B2 (ja) * 1989-08-24 1996-01-10 武田薬品工業株式会社 神経成長因子分泌誘導剤
JP3150740B2 (ja) * 1991-12-26 2001-03-26 エーザイ株式会社 ジヒドロベンゾフラン誘導体
DE69200126D1 (de) * 1992-11-18 1994-07-07 Medafor Illkirch Graffenstaden Langkettige Fettalkohole mit neurotropischer und gedächtnissfördernder Wirkung.
JP2000229998A (ja) * 1998-12-08 2000-08-22 Fujisawa Pharmaceut Co Ltd 新規化合物
JP4469441B2 (ja) * 1999-02-10 2010-05-26 明治乳業株式会社 神経変性疾患の予防又は治療薬
JP4354585B2 (ja) * 1999-09-22 2009-10-28 明治乳業株式会社 シクロヘキセノール誘導体及びこれを含有する医薬
US20020006954A1 (en) * 2000-03-02 2002-01-17 Oklahoma Medical Research Foundation Desmethyl tocopherols for preventing or slowing degenerative neurological diseases
JP4745491B2 (ja) * 2000-10-11 2011-08-10 株式会社明治 インドール長鎖アルコール及びこれを含有する医薬
JP2002332283A (ja) * 2001-03-09 2002-11-22 Kuraray Co Ltd クロマン誘導体及びその製造方法
EP1474390B1 (en) * 2002-02-13 2009-07-22 Meiji Dairies Corporation Indole derivatives substituted with long-chain alcohols and medicaments containing them

Also Published As

Publication number Publication date
DE602004020359D1 (de) 2009-05-14
EP1664012A1 (fr) 2006-06-07
FR2860233A1 (fr) 2005-04-01
AU2004276040B2 (en) 2009-04-23
WO2005030748A1 (fr) 2005-04-07
CA2536791A1 (fr) 2005-04-07
ES2324616T3 (es) 2009-08-11
US7691900B2 (en) 2010-04-06
US20070105946A1 (en) 2007-05-10
CN100519546C (zh) 2009-07-29
CY1110470T1 (el) 2015-04-29
EP1664012B1 (fr) 2009-04-01
CN1849312A (zh) 2006-10-18
SI1664012T1 (sl) 2009-08-31
PL1664012T3 (pl) 2010-01-29
DK1664012T3 (da) 2009-07-27
JP2007506714A (ja) 2007-03-22
FR2860233B1 (fr) 2007-10-19
HK1092400A1 (en) 2007-02-09
ATE427307T1 (de) 2009-04-15
AU2004276040A1 (en) 2005-04-07

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