DE602004012572D1 - Makrozyklische verbindungen mit asparaginproteasehemmender wirkung und deren pharmazeutische verwendung - Google Patents

Makrozyklische verbindungen mit asparaginproteasehemmender wirkung und deren pharmazeutische verwendung

Info

Publication number
DE602004012572D1
DE602004012572D1 DE602004012572T DE602004012572T DE602004012572D1 DE 602004012572 D1 DE602004012572 D1 DE 602004012572D1 DE 602004012572 T DE602004012572 T DE 602004012572T DE 602004012572 T DE602004012572 T DE 602004012572T DE 602004012572 D1 DE602004012572 D1 DE 602004012572D1
Authority
DE
Germany
Prior art keywords
sub
alkyl
cycloalkyl
alkylen
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004012572T
Other languages
English (en)
Other versions
DE602004012572T2 (de
Inventor
Claudia Betschart
Marina Tintelnot-Blomley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27741562&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602004012572(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE602004012572D1 publication Critical patent/DE602004012572D1/de
Application granted granted Critical
Publication of DE602004012572T2 publication Critical patent/DE602004012572T2/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/08—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602004012572T 2003-07-03 2004-07-02 Makrozyklische verbindungen mit asparaginproteasehemmender wirkung und deren pharmazeutische verwendung Active DE602004012572T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0315654.4A GB0315654D0 (en) 2003-07-03 2003-07-03 Organic compounds
GB0315654 2003-07-03
PCT/EP2004/007247 WO2005003106A1 (en) 2003-07-03 2004-07-02 Macrocyclic compounds having aspartic protease inhibiting activity and pharmaceutical uses thereof

Publications (2)

Publication Number Publication Date
DE602004012572D1 true DE602004012572D1 (de) 2008-04-30
DE602004012572T2 DE602004012572T2 (de) 2009-04-16

Family

ID=27741562

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004012572T Active DE602004012572T2 (de) 2003-07-03 2004-07-02 Makrozyklische verbindungen mit asparaginproteasehemmender wirkung und deren pharmazeutische verwendung

Country Status (16)

Country Link
US (2) US20060223745A1 (de)
EP (1) EP1654241B1 (de)
JP (1) JP2009513510A (de)
CN (1) CN1809542A (de)
AT (1) ATE389642T1 (de)
AU (1) AU2004253667B2 (de)
BR (1) BRPI0412286A (de)
CA (1) CA2529571A1 (de)
DE (1) DE602004012572T2 (de)
ES (1) ES2300790T3 (de)
GB (1) GB0315654D0 (de)
HK (1) HK1090366A1 (de)
MX (1) MXPA05014011A (de)
PL (1) PL1654241T3 (de)
PT (1) PT1654241E (de)
WO (1) WO2005003106A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0500683D0 (en) 2005-01-13 2005-02-23 Novartis Ag Organic compounds
EP1851208A1 (de) * 2005-01-13 2007-11-07 Novartis AG Makrocyclische verbindungen als bace-hemmer
US7812013B2 (en) 2005-06-14 2010-10-12 Schering Corporation Macrocyclic heterocyclic aspartyl protease inhibitors
GB0526614D0 (en) * 2005-12-30 2006-02-08 Novartis Ag Organic compounds
CN107849026B (zh) 2015-07-29 2021-01-01 百时美施贵宝公司 携带烷基或环烷基p2′部分的因子xia大环抑制剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184241B1 (en) * 1998-08-24 2001-02-06 Kansas State University Research Foundation Aspartic protease inhibitors

Also Published As

Publication number Publication date
MXPA05014011A (es) 2006-03-02
AU2004253667B2 (en) 2008-12-18
GB0315654D0 (en) 2003-08-13
ES2300790T3 (es) 2008-06-16
ATE389642T1 (de) 2008-04-15
BRPI0412286A (pt) 2006-09-19
PL1654241T3 (pl) 2008-09-30
PT1654241E (pt) 2008-06-03
HK1090366A1 (en) 2006-12-22
EP1654241B1 (de) 2008-03-19
AU2004253667A1 (en) 2005-01-13
JP2009513510A (ja) 2009-04-02
CN1809542A (zh) 2006-07-26
EP1654241A1 (de) 2006-05-10
DE602004012572T2 (de) 2009-04-16
US20060223745A1 (en) 2006-10-05
WO2005003106A1 (en) 2005-01-13
US20080070885A1 (en) 2008-03-20
CA2529571A1 (en) 2005-01-13

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