DE602004002491D1 - Ein keramischer Überzug mit einem biologischen Aktivstoff und Verfahren zur Herstellung - Google Patents

Ein keramischer Überzug mit einem biologischen Aktivstoff und Verfahren zur Herstellung

Info

Publication number
DE602004002491D1
DE602004002491D1 DE602004002491T DE602004002491T DE602004002491D1 DE 602004002491 D1 DE602004002491 D1 DE 602004002491D1 DE 602004002491 T DE602004002491 T DE 602004002491T DE 602004002491 T DE602004002491 T DE 602004002491T DE 602004002491 D1 DE602004002491 D1 DE 602004002491D1
Authority
DE
Germany
Prior art keywords
preparation
ceramic coating
biological active
biological agent
implantable article
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004002491T
Other languages
English (en)
Other versions
DE602004002491T2 (de
Inventor
Panjian Li
Hai Bo Wen
Elizabeth A Hippensteel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DePuy Products Inc
Original Assignee
DePuy Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DePuy Products Inc filed Critical DePuy Products Inc
Publication of DE602004002491D1 publication Critical patent/DE602004002491D1/de
Application granted granted Critical
Publication of DE602004002491T2 publication Critical patent/DE602004002491T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/30Inorganic materials
    • A61L27/32Phosphorus-containing materials, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406Antibiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • A61L2300/414Growth factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606Coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
DE602004002491T 2003-01-31 2004-01-22 Ein keramischer Überzug mit einem biologischen Aktivstoff und Verfahren zur Herstellung Expired - Lifetime DE602004002491T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US355827 2003-01-31
US10/355,827 US7087086B2 (en) 2003-01-31 2003-01-31 Biological agent-containing ceramic coating and method

Publications (2)

Publication Number Publication Date
DE602004002491D1 true DE602004002491D1 (de) 2006-11-09
DE602004002491T2 DE602004002491T2 (de) 2007-05-03

Family

ID=32655588

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004002491T Expired - Lifetime DE602004002491T2 (de) 2003-01-31 2004-01-22 Ein keramischer Überzug mit einem biologischen Aktivstoff und Verfahren zur Herstellung

Country Status (6)

Country Link
US (1) US7087086B2 (de)
EP (1) EP1442755B1 (de)
JP (1) JP2004230174A (de)
AT (1) ATE340595T1 (de)
AU (1) AU2004200224B2 (de)
DE (1) DE602004002491T2 (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100036502A1 (en) * 2008-08-07 2010-02-11 Exogenesis Corporation Medical device for bone implant and method for producing such device
JP4699902B2 (ja) * 2003-10-27 2011-06-15 Hoya株式会社 リン酸カルシウムセラミックス多孔体及びその製造方法
US20050196519A1 (en) * 2004-03-08 2005-09-08 Depuy Products, Inc. Apparatus for producing a biomimetic coating on a medical implant
DE102004021244A1 (de) * 2004-04-30 2005-11-24 Immundiagnostik Ag Bioaktive Werkstoffe und Verfahren zur Verbesserung der Einwachseigenschaften von Knochenimplantaten
SE527610C2 (sv) * 2004-06-15 2006-04-25 Promimic Ab Förfarande för framställning av syntetiskt, kristallint kalciumfosfat i nanostorlek
US20080241353A1 (en) * 2004-08-10 2008-10-02 Yekimed Ag Biomimetic Process For Coating Substrates With A Biomimetic Solution Containing A Bioactive Substance And Use Of Said Process And Substrates In Bone, Connective Tissue-, Fat Tissue-And Muscle Tissue Engineering
US20060093646A1 (en) * 2004-10-28 2006-05-04 Cima Michael J Orthopedic and dental implant devices providing controlled drug delivery
US8329202B2 (en) * 2004-11-12 2012-12-11 Depuy Products, Inc. System and method for attaching soft tissue to an implant
CA2532388A1 (en) * 2005-01-07 2006-07-07 Inframat Corporation Coated medical devices and methods of making and using
JP2006275667A (ja) * 2005-03-28 2006-10-12 Iwate Univ 生体用金属に対する血清タンパク質複合体形成の評価方法
US20060257358A1 (en) * 2005-05-13 2006-11-16 Depuy Products, Inc. Suspension of calcium phosphate particulates for local delivery of therapeutic agents
US7531190B2 (en) * 2005-05-25 2009-05-12 Biomet Manufacturing Corp. Porous ceramic structure containing biologics
US20070016163A1 (en) * 2005-06-28 2007-01-18 Microchips, Inc. Medical and dental implant devices for controlled drug delivery
US9763788B2 (en) 2005-09-09 2017-09-19 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
US8936805B2 (en) 2005-09-09 2015-01-20 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
WO2007030752A2 (en) * 2005-09-09 2007-03-15 University Of Arkansas At Little Rock System and method for tissue generation and bone regeneration
WO2007044229A2 (en) * 2005-09-28 2007-04-19 Calcitec, Inc. Surface treatments for calcium phosphate-based implants
CA2629600C (en) 2005-11-14 2011-11-01 Biomet 3I, Inc. Deposition of discrete nanoparticles on an implant surface
WO2008079152A2 (en) * 2006-01-04 2008-07-03 University Of Connecticut Ceramic coating and method of preparation thereof
US8187660B2 (en) * 2006-01-05 2012-05-29 Howmedica Osteonics Corp. Method for fabricating a medical implant component and such component
US20070158446A1 (en) * 2006-01-05 2007-07-12 Howmedica Osteonics Corp. Method for fabricating a medical implant component and such component
US7836847B2 (en) * 2006-02-17 2010-11-23 Howmedica Osteonics Corp. Multi-station rotation system for use in spray operations
US7981479B2 (en) * 2006-02-17 2011-07-19 Howmedica Osteonics Corp. Multi-station rotation system for use in spray operations
US20080069854A1 (en) * 2006-08-02 2008-03-20 Inframat Corporation Medical devices and methods of making and using
CN101588826A (zh) * 2006-08-02 2009-11-25 英孚拉玛特公司 腔支撑装置及其制造及使用方法
WO2008051555A2 (en) 2006-10-24 2008-05-02 Biomet 3I, Llc. Deposition of discrete nanoparticles on a nanostructured surface of an implant
CA2689675A1 (en) * 2007-02-07 2008-08-14 Mcgill University Bioceramic implants having bioactive substance
EP2211763A4 (de) * 2007-11-06 2013-02-13 Univ Connecticut Keramik-/strukturproteinverbundstoffe und verfahren zu ihrer herstellung
US9149563B2 (en) * 2007-11-06 2015-10-06 The University Of Connecticut Calcium phosphate/structural protein composites and method of preparation thereof
JP5248848B2 (ja) * 2007-12-11 2013-07-31 山八歯材工業株式会社 インプラントの製造方法及び人工歯根の製造方法
ES2545781T3 (es) 2008-01-28 2015-09-15 Biomet 3I, Llc Implante superficial con mayor hidrofilia
US9011965B2 (en) * 2008-02-29 2015-04-21 Smith & Nephew, Inc. Gradient coating for biomedical applications
AU2009222172B2 (en) * 2008-02-29 2015-06-18 Smith & Nephew, Inc. Medical implant with coating and coating method
CA2734254C (en) 2008-08-13 2018-06-05 Smed-Ta/Td, Llc Orthopaedic screws
US9700431B2 (en) 2008-08-13 2017-07-11 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
WO2010019781A1 (en) 2008-08-13 2010-02-18 Smed-Ta/Td, Llc Drug delivery implants
US9616205B2 (en) 2008-08-13 2017-04-11 Smed-Ta/Td, Llc Drug delivery implants
US10842645B2 (en) 2008-08-13 2020-11-24 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
JP5687622B2 (ja) 2008-08-29 2015-03-18 スメド−ティーエイ/ティーディー・エルエルシー 整形外科インプラント
EP2453934B1 (de) 2009-06-18 2013-06-12 Teknimed Verfahren zur oberflächenaktivierung bei porösen biomaterialien
EP2269663B1 (de) 2009-07-03 2018-03-07 Armbruster Biotechnology GmbH Knochenimplantat und bioverbundstoff
US8641418B2 (en) 2010-03-29 2014-02-04 Biomet 3I, Llc Titanium nano-scale etching on an implant surface
ES2373896B1 (es) * 2010-07-30 2013-03-12 Universidad Complutense De Madrid Biomaterial con osteostatina para regeneración ósea e ingeniería tisular.
WO2012068239A1 (en) * 2010-11-17 2012-05-24 Zimmer, Inc. Ceramic monoblock implants with osseointegration fixation surfaces
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
ES2671740T3 (es) 2012-03-20 2018-06-08 Biomet 3I, Llc Superficie de tratamiento para una superficie de implante
WO2013142763A1 (en) 2012-03-22 2013-09-26 University Of Connecticut Biomimetic scaffold for bone regeneration
US20140141047A1 (en) * 2012-11-19 2014-05-22 Wisconsin Alumni Research Foundation Selection of platelet rich plasma components via mineral binding
EP3231453B1 (de) 2016-04-14 2019-12-25 Immundiagnostik AG Bone-sialopreotein(bsp)-funktionalisierte knochenersatzkörper
JP6967294B2 (ja) * 2017-02-02 2021-11-17 国立研究開発法人産業技術総合研究所 セラミックス結晶の被覆層を有する複合体とその製造方法
US10537658B2 (en) 2017-03-28 2020-01-21 DePuy Synthes Products, Inc. Orthopedic implant having a crystalline gallium-containing hydroxyapatite coating and methods for making the same
US10537661B2 (en) 2017-03-28 2020-01-21 DePuy Synthes Products, Inc. Orthopedic implant having a crystalline calcium phosphate coating and methods for making the same
EP3632881A4 (de) * 2017-05-22 2021-03-03 Hangzhou Erran Technology Co. Ltd. Biologisch aktive nanooxidkeramikschicht
EP3919022A4 (de) * 2019-01-31 2022-03-16 Cell-Medicine, Inc. Medizinisches instrument mit anorganischem salz-protein-komposit
CN112869897B (zh) * 2021-01-14 2022-01-25 南京医科大学附属口腔医院 一种氧化锆种植体表面处理方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
US5258029A (en) * 1988-09-29 1993-11-02 Collagen Corporation Method for improving implant fixation
JPH0629126B2 (ja) * 1989-03-29 1994-04-20 京都大学長 生体活性水酸アパタイト膜のコーティング法
JP3198125B2 (ja) * 1991-06-18 2001-08-13 株式会社アドバンス インプラントの製造方法
US5947893A (en) * 1994-04-27 1999-09-07 Board Of Regents, The University Of Texas System Method of making a porous prothesis with biodegradable coatings
US6180606B1 (en) * 1994-09-28 2001-01-30 Gensci Orthobiologics, Inc. Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
IT1288038B1 (it) * 1996-04-30 1998-09-10 Flametal S P A Procedimento per la preparazione di rivestimenti di idrossiapatite
US6143948A (en) * 1996-05-10 2000-11-07 Isotis B.V. Device for incorporation and release of biologically active agents
GB2316940A (en) * 1996-08-30 1998-03-11 Queen Mary & Westfield College Silicon-substituted hydroxyapatite
US6129928A (en) * 1997-09-05 2000-10-10 Icet, Inc. Biomimetic calcium phosphate implant coatings and methods for making the same
US6214049B1 (en) 1999-01-14 2001-04-10 Comfort Biomedical, Inc. Method and apparatus for augmentating osteointegration of prosthetic implant devices
US6139585A (en) * 1998-03-11 2000-10-31 Depuy Orthopaedics, Inc. Bioactive ceramic coating and method
AU772751B2 (en) * 1998-09-15 2004-05-06 Isotis N.V. Method for coating medical implants
JP2003521351A (ja) * 2000-02-04 2003-07-15 イソティス エヌ.ブイ. 蛋白質性コーティング
JP2003535620A (ja) * 2000-02-18 2003-12-02 リジェネレーション テクノロジーズ インク. 増殖因子および他の添加物を注入した移植用組織
GB0010411D0 (en) 2000-04-28 2000-06-14 Abonetics Ltd A process for the preparation of carbonated biomedical materials
US6461382B1 (en) * 2000-09-22 2002-10-08 Edwards Lifesciences Corporation Flexible heart valve having moveable commissures

Also Published As

Publication number Publication date
ATE340595T1 (de) 2006-10-15
US20040153165A1 (en) 2004-08-05
EP1442755A1 (de) 2004-08-04
US7087086B2 (en) 2006-08-08
JP2004230174A (ja) 2004-08-19
AU2004200224A1 (en) 2004-08-19
DE602004002491T2 (de) 2007-05-03
EP1442755B1 (de) 2006-09-27
AU2004200224B2 (en) 2010-03-25

Similar Documents

Publication Publication Date Title
DE602004002491D1 (de) Ein keramischer Überzug mit einem biologischen Aktivstoff und Verfahren zur Herstellung
US9402933B2 (en) Structured coatings for implants and process for the preparation thereof
WO2006004686A3 (en) Bioceramic coated apparatus and method of forming the same
ATE448811T1 (de) Verfahren zur verbesserung der anhaftung von weichteilgewebe und implantate, die gebrauch von diesem verfahen machen
SE9901973D0 (sv) Implantat för applicering i ben och förfarande och användning vid sådant implantat
DE602004019938D1 (de) Beschichtete implantate und beschichtungsverfahren
WO2004101017A3 (de) Biokompatibel beschichtete medizinische implantate
FI921802A (fi) Uusia bioaktiivisia pinnotteita ja niiden valmistus ja käyttö
DE1079809T1 (de) Pharmazeutische zusammensetzung mit magensaftresistentem überzug und methode zur herstellung
HK1100486A1 (en) Bone implants and method of preparing the same
DE69933880D1 (de) Stenttransplantat beschichtungen mit ausgewähltem klebeeigenschaften, mandrin und verfahren zur herstellung dieses stenttransplantats
SE0102389L (sv) Förfarande för behandling av implantat genom beläggning med kalciumfosfat och bentillväxtstimulerande medel
ATE389043T1 (de) Verfahren zur beschichtung eines substrates mit calciumphosphat
DE60232120D1 (de) Verfahren zur Herstellung von L-Lysin oder L-Arginin unter Verwendung methanolassimilierender Bakterien
DE60216288D1 (de) Elektrostatisches sprühbeschichten (eds) von biokompatiblen beschichtungen auf metallische substrate
WO2004098436A3 (en) Method for producing adherent coatings
Wang et al. Proliferation and differentiation of osteoblast‐like MC3T3‐E1 cells on biomimetically and electrolytically deposited calcium phosphate coatings
DE60304584D1 (de) Unter verringerter sauerstoffkonzentration mit einem osteoinduktiven protein beschichtetes metallimplantat
DE69933351D1 (de) Verfahren zur Herstellung eines Gegenstandes mit katalytischer Oberflächenschicht
DE602004016008D1 (de) Biosynthetisches implantat und seine verwendung und verfahren zur reduzierung des risikos der bildung von bindegewebe nach der implantation
GB9423277D0 (en) Pulsed laser deposition of coatings
Lee et al. In vitro effects of mussel-inspired polydopamine coating on Ti6Al4V alloy
EP1405648A4 (de) Verfahren zur beschichtung von substraten für lebendes körpergewebe
DE3877090D1 (de) Artikel mit einer blutkompatiblen oberflaeche und verfahren zu ihrer herstellung.
BR0200698A (pt) Processo para obtenção de um revestimento bioativo de fosfato de cálcio sobre substratos sólidos

Legal Events

Date Code Title Description
8364 No opposition during term of opposition