DE60144573D1 - Verfahren und Zwischenprodukte bei der Synthese von L-Thymidin - Google Patents

Verfahren und Zwischenprodukte bei der Synthese von L-Thymidin

Info

Publication number
DE60144573D1
DE60144573D1 DE60144573T DE60144573T DE60144573D1 DE 60144573 D1 DE60144573 D1 DE 60144573D1 DE 60144573 T DE60144573 T DE 60144573T DE 60144573 T DE60144573 T DE 60144573T DE 60144573 D1 DE60144573 D1 DE 60144573D1
Authority
DE
Germany
Prior art keywords
thymidine
intermediates
synthesis
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60144573T
Other languages
English (en)
Inventor
Hajime Iizuka
Kazuhiko Togashi
Tsuneji Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Chemicals Inc
Original Assignee
Mitsui Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc
Application granted granted Critical
Publication of DE60144573D1 publication Critical patent/DE60144573D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60144573T 2000-11-29 2001-11-29 Verfahren und Zwischenprodukte bei der Synthese von L-Thymidin Expired - Lifetime DE60144573D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000362081 2000-11-29
JP2000380585 2000-12-14
PCT/JP2001/010437 WO2002044194A1 (fr) 2000-11-29 2001-11-29 Derives d'acide l-nucleique et procedes de synthese correspondants

Publications (1)

Publication Number Publication Date
DE60144573D1 true DE60144573D1 (de) 2011-06-16

Family

ID=26604760

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60144573T Expired - Lifetime DE60144573D1 (de) 2000-11-29 2001-11-29 Verfahren und Zwischenprodukte bei der Synthese von L-Thymidin

Country Status (6)

Country Link
US (1) US7125983B2 (de)
EP (1) EP1348712B1 (de)
JP (2) JP3942414B2 (de)
CN (2) CN100368422C (de)
DE (1) DE60144573D1 (de)
WO (1) WO2002044194A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
DE10216426A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US7595390B2 (en) 2003-04-28 2009-09-29 Novartis Ag Industrially scalable nucleoside synthesis
RU2361875C2 (ru) 2003-06-30 2009-07-20 Айденикс (Кайман) Лимитед СИНТЕЗ β-L-2'-ДЕЗОКСИНУКЛЕОЗИДОВ
US20050228175A1 (en) * 2004-03-12 2005-10-13 Ajinomoto Co., Inc. Production method of 2-deoxy-L-ribose compound
CA2643748A1 (en) 2006-03-15 2007-09-20 Novartis Ag Process for preparing l-nucleic acid derivatives and intermediates thereof
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain vehicles, installations and methods
JP2011084471A (ja) * 2008-01-28 2011-04-28 Ajinomoto Co Inc 核酸誘導体及びその中間体化合物の製造方法
JP5730854B2 (ja) 2009-04-06 2015-06-10 大塚製薬株式会社 デシタビンとシチジンデアミナーゼ阻害剤との組合せ、およびがんの治療におけるその使用
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
TWI477508B (zh) 2009-04-06 2015-03-21 Otsuka Pharma Co Ltd 用以治療癌症之組成物及方法
EP2416781B1 (de) * 2009-04-06 2017-03-08 Otsuka Pharmaceutical Co., Ltd. Kombination von antineoplastischen arzneimitteln auf cytidin-basis mit cytidin-deaminase-inhibitor und ihre verwendung in der krebstherapie
CN101555266B (zh) * 2009-05-25 2011-11-30 上海医药工业研究院 一种替比夫定的制备方法
RU2681939C2 (ru) 2013-10-29 2019-03-14 Оцука Фармасьютикал Ко., Лтд. Путь синтезирования 2'-дезокси-2'2'-дифтортетрагидроуридинов
CN104744538A (zh) * 2013-12-26 2015-07-01 康普药业股份有限公司 一种替比夫定的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4762823A (en) * 1985-10-16 1988-08-09 Sloan-Kettering Institute For Cancer Research Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
US5384396A (en) * 1988-02-23 1995-01-24 The University Of Georgia Research Foundation, Inc. Process for the deoxygenation of nucleosides
US5008384A (en) 1988-07-12 1991-04-16 Pfizer Inc. Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine
US5200514A (en) * 1990-01-19 1993-04-06 University Of Georgia Research Foundation, Inc. Synthesis of 2'-deoxypyrimidine nucleosides
JP3259191B2 (ja) 1992-09-11 2002-02-25 宏明 沢井 ２，２′−アンヒドロアラビノシルチミン誘導体の合成法
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
AU6630996A (en) * 1995-08-04 1997-03-05 Kobayashi Perfumery Co., Ltd. Process for producing azido nucleoside derivatives
WO1998039347A2 (en) * 1997-03-05 1998-09-11 The Regents Of The University Of California Synthesis of l-ribose and 2-deoxy l-ribose
ES2255295T3 (es) * 1998-08-10 2006-06-16 Idenix (Cayman) Limited 2'-deoxi-beta-l-nucleosidos para el tratamiento de la hepatitis b.

Also Published As

Publication number Publication date
CN102241720B (zh) 2014-01-29
CN1478096A (zh) 2004-02-25
US7125983B2 (en) 2006-10-24
JP2002241390A (ja) 2002-08-28
EP1348712A1 (de) 2003-10-01
JP2006232861A (ja) 2006-09-07
EP1348712A4 (de) 2008-04-02
EP1348712B1 (de) 2011-05-04
JP3942414B2 (ja) 2007-07-11
US20040063926A1 (en) 2004-04-01
WO2002044194A1 (fr) 2002-06-06
CN100368422C (zh) 2008-02-13
CN102241720A (zh) 2011-11-16

Similar Documents

Publication Publication Date Title
DE69933390D1 (de) Verfahren und produkte der reinigung von anhydrozuckeralkoholen
DE60144573D1 (de) Verfahren und Zwischenprodukte bei der Synthese von L-Thymidin
DE60129522D1 (de) Gipszusammensetzungen und dazugehörende verfahren
DE60032275D1 (de) Verfahren und Zwischenprodukte zur Herstellung von Antikrebsmitteln
DE60102356D1 (de) Asymmetrische synthese von pregabalin
DE69924930D1 (de) Synthese von Oligonukleotiden
DE60039177D1 (de) Verfahren zur verbesserung der haut und des pelzes von haustieren
DE60118969D1 (de) Stirnwandbereich-airbag zum schutz von fussgängern
DE60020100D1 (de) Dimerverbindungen und als inhibitoren der neuramidinase
DE50112013D1 (de) Deodorantien und antiperspirantien
ATE452540T1 (de) Zusammensetzung und verfahren
ATE555078T1 (de) Verfahren und zwischenprodukte
DE60122160D1 (de) Antennenstruktur und zugehöriges verfahren
DE60218860D1 (de) Polymerisate und ihre synthese
ATE242750T1 (de) Synthese von kristallinen silicoaluminophosphaten
DE602005020603D1 (de) Synthese von trithiocarbonat-raft-agentia und zwischenprodukte daraus
DE60236790D1 (de) Piezoelektrischer oszillator und verfahren zu seiner herstellung
DE69722585D1 (de) Synthese von wellenformen
DE60201384D1 (de) Verfahren zur Synthese von Harnstoff
DE60107179D1 (de) Synthese von Styrol-Isopren Kautschuk
DE60100328D1 (de) Verfahren zur Gewinnung und Reinigung von Cyclobutanon
DE60031450D1 (de) Polymorph v von torasemid
DE60201280D1 (de) Verbundener Gegenstand und Verfahren zu dessen Herstellung
DE60003667D1 (de) Förderung der bildung von dialkyldihalosilanen in der direktsynthese
DE60238134D1 (de) Verfahren zur reagieren von alkaloiden und verwendung der reaktionsproduckte in der bereitstellung von medikamenten