DE60126337D1 - Verfahren zum screenen für gpr40-liganden - Google Patents
Verfahren zum screenen für gpr40-ligandenInfo
- Publication number
- DE60126337D1 DE60126337D1 DE60126337T DE60126337T DE60126337D1 DE 60126337 D1 DE60126337 D1 DE 60126337D1 DE 60126337 T DE60126337 T DE 60126337T DE 60126337 T DE60126337 T DE 60126337T DE 60126337 D1 DE60126337 D1 DE 60126337D1
- Authority
- DE
- Germany
- Prior art keywords
- screening
- ligands
- gpr40
- gpr40 ligands
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0031527.5A GB0031527D0 (en) | 2000-12-22 | 2000-12-22 | New use |
| GB0031527 | 2000-12-22 | ||
| PCT/US2001/048985 WO2002057783A2 (en) | 2000-12-22 | 2001-12-18 | Method of screening for gpr40 ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60126337D1 true DE60126337D1 (de) | 2007-03-15 |
| DE60126337T2 DE60126337T2 (de) | 2007-11-15 |
Family
ID=9905799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60126337T Expired - Lifetime DE60126337T2 (de) | 2000-12-22 | 2001-12-18 | Verfahren zum screenen für gpr40-liganden |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1354200B1 (de) |
| AT (1) | ATE352784T1 (de) |
| AU (1) | AU2002246702A1 (de) |
| DE (1) | DE60126337T2 (de) |
| ES (1) | ES2280427T3 (de) |
| GB (1) | GB0031527D0 (de) |
| WO (1) | WO2002057783A2 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1479768B1 (de) | 2002-02-14 | 2010-04-28 | Takeda Pharmaceutical Company Limited | Neues screening-verfahren |
| AU2003261935A1 (en) * | 2002-09-06 | 2004-03-29 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
| US7056685B1 (en) | 2002-11-05 | 2006-06-06 | Amgen Inc. | Receptor ligands and methods of modulating receptors |
| AU2003277576A1 (en) * | 2002-11-08 | 2004-06-07 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
| WO2004050853A2 (en) * | 2002-12-04 | 2004-06-17 | Synaptic Pharmaceutical Corporation | Uses of the snorf55 receptor |
| WO2004065960A1 (ja) | 2003-01-17 | 2004-08-05 | Takeda Pharmaceutical Company Limited | 新規スクリーニング方法 |
| JP4574177B2 (ja) * | 2003-01-17 | 2010-11-04 | 武田薬品工業株式会社 | 新規スクリーニング方法 |
| US20060160088A1 (en) * | 2003-02-17 | 2006-07-20 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 40 (gpr40) |
| US7820837B2 (en) | 2003-05-30 | 2010-10-26 | Takeda Pharmaceutical Company Limited | Condensed ring compound |
| US20070011755A1 (en) * | 2003-08-18 | 2007-01-11 | Betagnon Ab | Diabetes type 2 animal model |
| US7834013B2 (en) | 2003-11-19 | 2010-11-16 | Glaxosmithkline Llc | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to GPR40 |
| EP1737809B1 (de) | 2004-02-27 | 2013-09-18 | Amgen, Inc | Verbindungen, pharmazeutische zusammensetzungen und verfahren zur verwendung bei der behandlung von stoffwechselstörungen |
| US7517910B2 (en) | 2004-03-30 | 2009-04-14 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
| US20060003344A1 (en) * | 2004-06-30 | 2006-01-05 | Pfizer Inc. | Methods related to a single nucleotide polymorphism of the G protein coupled receptor, GPR40 |
| JP2007284350A (ja) | 2004-07-27 | 2007-11-01 | Takeda Chem Ind Ltd | 糖尿病治療剤 |
| US7465804B2 (en) | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
| AU2006291234A1 (en) | 2005-09-14 | 2007-03-22 | Amgen Inc. | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| US8252521B2 (en) | 2005-11-04 | 2012-08-28 | Eisai R&D Management Co., Ltd. | Method of screening substance useful in treating disease with the use of GPR40 and phospholipase |
| WO2008030520A1 (en) | 2006-09-07 | 2008-03-13 | Amgen Inc. | Heterocyclic gpr40 modulators |
| WO2008030618A1 (en) | 2006-09-07 | 2008-03-13 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
| JP2010524932A (ja) | 2007-04-16 | 2010-07-22 | アムジエン・インコーポレーテツド | 置換ビフェニルフェノキシ−、チオフェニル−及びアミノフェニルプロパン酸ｇｐｒ４０調節物質 |
| WO2009048527A1 (en) | 2007-10-10 | 2009-04-16 | Amgen Inc. | Substituted biphenyl gpr40 modulators |
| JP2011515341A (ja) | 2008-03-06 | 2011-05-19 | アムジエン・インコーポレーテツド | 代謝障害の治療に有用な立体配座的に制限されたカルボン酸誘導体 |
| CA2739888C (en) | 2008-10-15 | 2013-11-19 | Amgen Inc. | Spirocyclic gpr40 modulators |
| PL233938B1 (pl) * | 2018-01-08 | 2019-12-31 | CELON PHARMA Spólka Akcyjna | Pochodne kwasu 3-fenylo-4-heksynowego jako agoniści GPR40 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6309854B1 (en) * | 1996-12-17 | 2001-10-30 | Smithkline Beecham Corporation | Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72 |
| US6555339B1 (en) * | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
| WO2002044362A1 (fr) * | 2000-12-01 | 2002-06-06 | Yamanouchi Pharmaceutical Co., Ltd. | Procede de depistage d'un remede |
-
2000
- 2000-12-22 GB GBGB0031527.5A patent/GB0031527D0/en not_active Ceased
-
2001
- 2001-12-18 EP EP01994292A patent/EP1354200B1/de not_active Expired - Lifetime
- 2001-12-18 ES ES01994292T patent/ES2280427T3/es not_active Expired - Lifetime
- 2001-12-18 AT AT01994292T patent/ATE352784T1/de not_active IP Right Cessation
- 2001-12-18 AU AU2002246702A patent/AU2002246702A1/en not_active Abandoned
- 2001-12-18 DE DE60126337T patent/DE60126337T2/de not_active Expired - Lifetime
- 2001-12-18 WO PCT/US2001/048985 patent/WO2002057783A2/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002246702A1 (en) | 2002-07-30 |
| EP1354200B1 (de) | 2007-01-24 |
| ATE352784T1 (de) | 2007-02-15 |
| GB0031527D0 (en) | 2001-02-07 |
| DE60126337T2 (de) | 2007-11-15 |
| WO2002057783A2 (en) | 2002-07-25 |
| ES2280427T3 (es) | 2007-09-16 |
| WO2002057783A3 (en) | 2003-08-07 |
| EP1354200A2 (de) | 2003-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |