DE60115849D1 - Methode und katalytisches system zur stereoselektiven invertierung eines chiralen zentrums in einer chemischen verbindung - Google Patents

Methode und katalytisches system zur stereoselektiven invertierung eines chiralen zentrums in einer chemischen verbindung

Info

Publication number
DE60115849D1
DE60115849D1 DE60115849T DE60115849T DE60115849D1 DE 60115849 D1 DE60115849 D1 DE 60115849D1 DE 60115849 T DE60115849 T DE 60115849T DE 60115849 T DE60115849 T DE 60115849T DE 60115849 D1 DE60115849 D1 DE 60115849D1
Authority
DE
Germany
Prior art keywords
chiral center
chemical compound
inverting
stereoselective
catalytic system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60115849T
Other languages
English (en)
Other versions
DE60115849T2 (de
Inventor
Weiguo Liu
Scott Laneman
John Ager
Phillip Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EXCELSYN MOLECULAR DEV Ltd
Original Assignee
EXCELSYN MOLECULAR DEV Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EXCELSYN MOLECULAR DEV Ltd filed Critical EXCELSYN MOLECULAR DEV Ltd
Publication of DE60115849D1 publication Critical patent/DE60115849D1/de
Application granted granted Critical
Publication of DE60115849T2 publication Critical patent/DE60115849T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60115849T 2000-02-23 2001-02-22 Methode und katalytisches system zur stereoselektiven invertierung eines chiralen zentrums in einer chemischen verbindung Expired - Lifetime DE60115849T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51088200A 2000-02-23 2000-02-23
US510882 2000-02-23
PCT/US2001/005688 WO2001062948A2 (en) 2000-02-23 2001-02-22 Method and catalyst system for stereoselectively inverting a chiral center of a chemical compound

Publications (2)

Publication Number Publication Date
DE60115849D1 true DE60115849D1 (de) 2006-01-19
DE60115849T2 DE60115849T2 (de) 2006-08-03

Family

ID=24032576

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60115849T Expired - Lifetime DE60115849T2 (de) 2000-02-23 2001-02-22 Methode und katalytisches system zur stereoselektiven invertierung eines chiralen zentrums in einer chemischen verbindung

Country Status (7)

Country Link
US (1) US6365380B2 (de)
EP (1) EP1257659B1 (de)
JP (1) JP2003523750A (de)
AT (1) ATE312936T1 (de)
AU (1) AU2001247218A1 (de)
DE (1) DE60115849T2 (de)
WO (1) WO2001062948A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SV2003000617A (es) * 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
US7202070B2 (en) * 2000-10-31 2007-04-10 Biocatalytics, Inc. Method for reductive amination of a ketone using a mutated enzyme
GB0206415D0 (en) * 2002-03-19 2002-05-01 Glaxo Group Ltd Deracemisation of amines
WO2006113085A2 (en) * 2005-03-28 2006-10-26 Biocatalytics, Inc. D-amino acid dehydrogenase and method of making d-amino acids
WO2008080138A1 (en) * 2006-12-22 2008-07-03 Richmond Chemical Corporation Stereoinversion of amino acids
US7588923B2 (en) * 2007-03-02 2009-09-15 Richmond Chemical Corporation Method to increase the yield and improve purification of products from transaminase reactions
EP2225271B1 (de) * 2007-12-03 2013-07-31 ITALFARMACO S.p.A. Neue nichtselektive analoga von somatostatin
EP2067786A1 (de) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Neue nichtselektive Analoga von Somatostatin
CN110938580A (zh) * 2019-12-26 2020-03-31 江南大学 一种提高d-酪氨酸生产效率的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1767389A1 (de) 1968-05-06 1971-09-02 Bayer Ag Verfahren zur Abtrennung von Pyrogenen aus Rohpraeparaten von L-Asparaginase
CH586233A5 (de) 1971-01-18 1977-03-31 Pentapharm Ag
HU193902B (en) 1983-09-01 1987-12-28 Genetics Inst Process for preparing l-amino acids by means of transamination
GB8700462D0 (en) 1987-01-09 1987-02-11 Shell Int Research Alkene derivatives
US5135860A (en) 1991-11-06 1992-08-04 E. I. Du Pont De Nemours And Company Process for preparing glyoxylic acid/aminomethylphosphonic acid mixtures
US5364797A (en) 1993-05-20 1994-11-15 Mobil Oil Corp. Sensor device containing mesoporous crystalline material
GB9410388D0 (en) 1994-05-24 1994-07-13 Erba Carlo Spa Method for the preparation of 9-amino camptothecin
JPH08322591A (ja) * 1995-06-02 1996-12-10 Sumitomo Pharmaceut Co Ltd 光学分割により光学的に純粋な１，２，３，４−テトラヒドロキノリン−２−酢酸エステル類を得る方法
US5728555A (en) 1996-09-30 1998-03-17 Monsanto Company Preparation of d-amino acids by direct fermentative means
US5922183A (en) 1997-06-23 1999-07-13 Eic Laboratories, Inc. Metal oxide matrix biosensors

Also Published As

Publication number Publication date
US20010021519A1 (en) 2001-09-13
ATE312936T1 (de) 2005-12-15
US6365380B2 (en) 2002-04-02
EP1257659A2 (de) 2002-11-20
WO2001062948A2 (en) 2001-08-30
EP1257659B1 (de) 2005-12-14
WO2001062948A3 (en) 2002-03-07
AU2001247218A1 (en) 2001-09-03
DE60115849T2 (de) 2006-08-03
JP2003523750A (ja) 2003-08-12

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