AU2001247218A1 - Method and catalyst system for stereoselectively inverting chiral center of a chemical compound - Google Patents

Method and catalyst system for stereoselectively inverting chiral center of a chemical compound

Info

Publication number
AU2001247218A1
AU2001247218A1 AU2001247218A AU4721801A AU2001247218A1 AU 2001247218 A1 AU2001247218 A1 AU 2001247218A1 AU 2001247218 A AU2001247218 A AU 2001247218A AU 4721801 A AU4721801 A AU 4721801A AU 2001247218 A1 AU2001247218 A1 AU 2001247218A1
Authority
AU
Australia
Prior art keywords
stereoselectively
chiral center
chemical compound
inverting
catalyst system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001247218A
Inventor
David John Ager
Scott Laneman
Weiguo Liu
Paul Phillip Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PCBU Services Inc
Original Assignee
Great Lakes Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Great Lakes Chemical Corp filed Critical Great Lakes Chemical Corp
Publication of AU2001247218A1 publication Critical patent/AU2001247218A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A process for stereoselectively inverting a chiral center of a chemical compound is disclosed. The process first consists of forming a mixture of the chemical comopund, an enzymatic system, and a metal catalyst. Next, the process stereoselectively dehydrogenates a group attached to the chiral center with the enzymatic system in the presence of an oxidant to produce a dehydrogenated group, Lastly, the process hydrogenates the dehydrogenated group with the metal catalyst in the presence of a hydrogen source to stereoselectively invert the chiral center of the chemical compound.
AU2001247218A 2000-02-23 2001-02-22 Method and catalyst system for stereoselectively inverting chiral center of a chemical compound Abandoned AU2001247218A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51088200A 2000-02-23 2000-02-23
US09510882 2000-02-23
PCT/US2001/005688 WO2001062948A2 (en) 2000-02-23 2001-02-22 Method and catalyst system for stereoselectively inverting a chiral center of a chemical compound

Publications (1)

Publication Number Publication Date
AU2001247218A1 true AU2001247218A1 (en) 2001-09-03

Family

ID=24032576

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001247218A Abandoned AU2001247218A1 (en) 2000-02-23 2001-02-22 Method and catalyst system for stereoselectively inverting chiral center of a chemical compound

Country Status (7)

Country Link
US (1) US6365380B2 (en)
EP (1) EP1257659B1 (en)
JP (1) JP2003523750A (en)
AT (1) ATE312936T1 (en)
AU (1) AU2001247218A1 (en)
DE (1) DE60115849T2 (en)
WO (1) WO2001062948A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SV2003000617A (en) * 2000-08-31 2003-01-13 Lilly Co Eli INHIBITORS OF PROTEASA PEPTIDOMIMETICA REF. X-14912M
US7202070B2 (en) * 2000-10-31 2007-04-10 Biocatalytics, Inc. Method for reductive amination of a ketone using a mutated enzyme
GB0206415D0 (en) * 2002-03-19 2002-05-01 Glaxo Group Ltd Deracemisation of amines
WO2006113085A2 (en) * 2005-03-28 2006-10-26 Biocatalytics, Inc. D-amino acid dehydrogenase and method of making d-amino acids
WO2008080138A1 (en) * 2006-12-22 2008-07-03 Richmond Chemical Corporation Stereoinversion of amino acids
US7588923B2 (en) * 2007-03-02 2009-09-15 Richmond Chemical Corporation Method to increase the yield and improve purification of products from transaminase reactions
EP2067786A1 (en) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Novel non selective analogs of somatostatin
CA2702940C (en) * 2007-12-03 2016-09-13 Andrea Vitali New non-selective somatostatin analogues
CN110938580A (en) * 2019-12-26 2020-03-31 江南大学 Method for improving production efficiency of D-tyrosine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1767389A1 (en) 1968-05-06 1971-09-02 Bayer Ag Process for the separation of pyrogens from crude preparations of L-asparaginase
CH586233A5 (en) 1971-01-18 1977-03-31 Pentapharm Ag
DE3482982D1 (en) 1983-09-01 1990-09-20 Genetics Inst PRODUCTION OF L-AMINO ACIDS BY TRANSAMINATION.
GB8700462D0 (en) 1987-01-09 1987-02-11 Shell Int Research Alkene derivatives
US5135860A (en) 1991-11-06 1992-08-04 E. I. Du Pont De Nemours And Company Process for preparing glyoxylic acid/aminomethylphosphonic acid mixtures
US5364797A (en) 1993-05-20 1994-11-15 Mobil Oil Corp. Sensor device containing mesoporous crystalline material
GB9410388D0 (en) 1994-05-24 1994-07-13 Erba Carlo Spa Method for the preparation of 9-amino camptothecin
JPH08322591A (en) * 1995-06-02 1996-12-10 Sumitomo Pharmaceut Co Ltd Production of optically pure 1,2,3,4-tetrahydroquinoline-2-acetic acid esters by optical resolution method
US5728555A (en) 1996-09-30 1998-03-17 Monsanto Company Preparation of d-amino acids by direct fermentative means
US5922183A (en) 1997-06-23 1999-07-13 Eic Laboratories, Inc. Metal oxide matrix biosensors

Also Published As

Publication number Publication date
ATE312936T1 (en) 2005-12-15
US6365380B2 (en) 2002-04-02
US20010021519A1 (en) 2001-09-13
JP2003523750A (en) 2003-08-12
WO2001062948A3 (en) 2002-03-07
WO2001062948A2 (en) 2001-08-30
EP1257659A2 (en) 2002-11-20
DE60115849D1 (en) 2006-01-19
EP1257659B1 (en) 2005-12-14
DE60115849T2 (en) 2006-08-03

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