DE60115274T2 - Verwendung von antiprogestinen zur prophylaxe und behandlung von hormonabhängigen erkrankungen - Google Patents

Verwendung von antiprogestinen zur prophylaxe und behandlung von hormonabhängigen erkrankungen Download PDF

Info

Publication number
DE60115274T2
DE60115274T2 DE60115274T DE60115274T DE60115274T2 DE 60115274 T2 DE60115274 T2 DE 60115274T2 DE 60115274 T DE60115274 T DE 60115274T DE 60115274 T DE60115274 T DE 60115274T DE 60115274 T2 DE60115274 T2 DE 60115274T2
Authority
DE
Germany
Prior art keywords
antiprogestin
treatment
breast cancer
hormone
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60115274T
Other languages
German (de)
English (en)
Other versions
DE60115274D1 (de
Inventor
Jens Hoffmann
Rosemarie Lichtner
Gerhard Siemeister
Martin Schneider
Ulrike Fuhrmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of DE60115274D1 publication Critical patent/DE60115274D1/de
Application granted granted Critical
Publication of DE60115274T2 publication Critical patent/DE60115274T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60115274T 2000-10-18 2001-10-17 Verwendung von antiprogestinen zur prophylaxe und behandlung von hormonabhängigen erkrankungen Expired - Lifetime DE60115274T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24099800P 2000-10-18 2000-10-18
EP00250341 2000-10-18
US240998P 2000-10-18
EP00250341 2000-10-18
PCT/EP2001/012005 WO2002032430A1 (en) 2000-10-18 2001-10-17 Use of antiprogestins for prophylaxis and treatment of hormone-dependent diseases

Publications (2)

Publication Number Publication Date
DE60115274D1 DE60115274D1 (de) 2005-12-29
DE60115274T2 true DE60115274T2 (de) 2006-07-27

Family

ID=26072951

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60115274T Expired - Lifetime DE60115274T2 (de) 2000-10-18 2001-10-17 Verwendung von antiprogestinen zur prophylaxe und behandlung von hormonabhängigen erkrankungen

Country Status (26)

Country Link
US (1) US7378406B2 (enExample)
EP (1) EP1328276B1 (enExample)
JP (2) JP2004511522A (enExample)
KR (1) KR100632908B1 (enExample)
CN (1) CN1512886A (enExample)
AT (1) ATE310522T1 (enExample)
AU (2) AU2002218243B2 (enExample)
BG (1) BG107743A (enExample)
BR (1) BR0114665A (enExample)
CA (1) CA2423017C (enExample)
CY (1) CY1104981T1 (enExample)
CZ (1) CZ299942B6 (enExample)
DE (1) DE60115274T2 (enExample)
DK (1) DK1328276T3 (enExample)
EE (1) EE05259B1 (enExample)
ES (1) ES2253443T3 (enExample)
HR (1) HRP20030387A2 (enExample)
HU (1) HUP0301460A3 (enExample)
IL (2) IL154975A0 (enExample)
MX (1) MXPA03002954A (enExample)
NO (1) NO20031740L (enExample)
NZ (1) NZ538346A (enExample)
PL (1) PL360151A1 (enExample)
SI (1) SI1328276T1 (enExample)
SK (1) SK287124B6 (enExample)
WO (1) WO2002032430A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY27301A1 (es) * 2001-05-25 2003-02-28 Schering Ag Uso y composiciones de antiprogestinas para el tratamiento de enfermedades de la próstata
DE10159217A1 (de) 2001-11-27 2003-06-05 Schering Ag 17alpha-Alkyl-17ß-oxy-estratriene und Zwischenprodukte zu deren Herstellung, Verwendung der 17alpha-Alkyl-17ß-oxy-estratriene zur Herstellung von Arzneimitteln sowie pharmazeutische Präparate
US20040242551A1 (en) * 2003-05-28 2004-12-02 Schering Ag Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases
US9517240B2 (en) * 2006-09-26 2016-12-13 The Regents Of The University Of California Methods and compositions for cancer prevention and treatment
US20080261929A1 (en) * 2007-04-23 2008-10-23 Jens Hoffmann Combination of progesterone-receptor antagonist together with an aromatase inhibitor for use in brca mediated diseases
CA2683809A1 (en) * 2007-04-23 2008-10-30 Bayer Schering Pharma Aktiengesellschaft Progesterone-receptor antagonist for use in brca alone or as combination with antiestrogen
US20080268041A1 (en) * 2007-04-23 2008-10-30 Jens Hoffmann Combination of progesterone-receptor antagonist together with none-steroidal antiestrogen for use in brca mediated diseases
TWI477276B (zh) * 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
TWI539953B (zh) * 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
DE102009034367A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034362A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102010007722A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010007719A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
MX2012010327A (es) * 2010-03-22 2012-11-16 Repros Therapeutics Inc Composiciones y metodos para la administracion no toxica de antiprogestinas.
CA2872644A1 (en) 2012-05-31 2013-12-05 Allergan Pharmaceuticals International Limited Formulations and methods for vaginal delivery of antiprogestins
US9545411B2 (en) 2012-11-02 2017-01-17 Repros Therapeutics Inc. Methods and compositions for treating progesterone-dependent conditions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3733478A1 (de) * 1987-10-01 1989-04-13 Schering Ag Antigestagen- und antioestrogenwirksame verbindungen zur geburtseinleitung und zum schwangerschaftsabbruch sowie zur behandlung gynaekologischer stoerungen und hormonabhaengiger tumore
DE19706061A1 (de) * 1997-02-07 1998-08-13 Schering Ag Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette

Also Published As

Publication number Publication date
MXPA03002954A (es) 2003-08-07
AU2002218243B2 (en) 2006-07-13
NO20031740L (no) 2003-06-17
CA2423017A1 (en) 2002-04-25
BG107743A (bg) 2004-01-30
JP2004511522A (ja) 2004-04-15
KR100632908B1 (ko) 2006-10-13
BR0114665A (pt) 2004-01-13
NO20031740D0 (no) 2003-04-15
NZ538346A (en) 2007-03-30
SI1328276T1 (sl) 2006-04-30
DK1328276T3 (da) 2006-04-03
IL154975A0 (en) 2003-10-31
JP2010077158A (ja) 2010-04-08
IL154975A (en) 2007-05-15
CN1512886A (zh) 2004-07-14
DE60115274D1 (de) 2005-12-29
CA2423017C (en) 2009-01-06
KR20030044007A (ko) 2003-06-02
HRP20030387A2 (en) 2005-04-30
CY1104981T1 (el) 2010-03-03
HUP0301460A3 (en) 2010-01-28
HUP0301460A2 (hu) 2003-10-28
WO2002032430A1 (en) 2002-04-25
ES2253443T3 (es) 2006-06-01
PL360151A1 (en) 2004-09-06
AU1824302A (en) 2002-04-29
EE05259B1 (et) 2010-02-15
ATE310522T1 (de) 2005-12-15
EE200300155A (et) 2003-08-15
SK4742003A3 (en) 2004-09-08
CZ299942B6 (cs) 2008-12-29
US7378406B2 (en) 2008-05-27
EP1328276A1 (en) 2003-07-23
US20040048841A1 (en) 2004-03-11
EP1328276B1 (en) 2005-11-23
SK287124B6 (sk) 2009-12-07

Similar Documents

Publication Publication Date Title
DE19739916C2 (de) Verwendung einer Kombination aus einem Gestagen und einem Estrogen zur kontinuierlichen Ovulationshemmung und ggf. gleichzeitigen Behandlung und/oder Prophylaxe von Tumoren der Brustdrüsen
DE69532894T2 (de) Verfahren zur empfängnisverhütung
EP0723439B1 (de) Kombination von progesteronantagonisten und antiöstrogenen mit partialer agonistischer wirkung für die hormonsubstitutions-therapie für peri- und postmenopausale frauen
DE60318092T2 (de) Pharmazeutische zusammensetzung enthaltend estetrolderivate und anwendung in der krebsbehandlung
DE60216630T2 (de) Verwendung von östrogen in kombination mit progestogen für die hormonsubstitutiionstherapie
KR100632908B1 (ko) 호르몬-의존성 질병의 예방 및 치료를 위한항프로게스틴의 용도
DD269557A5 (de) Verfahren zur herstellung einer zusammensetzung zur wirksamen prephylaxe von brustkrebs bei frauen und zur empfaengnisverhuetung
EP0799042A1 (de) Progesteronantagonistisch- und antiöstrogen wirksame verbindungen zur gemeinsamen verwendung für die weibliche kontrazeption
AU2002218243A1 (en) Use of antiprogestins for prophylaxis and treatment of hormone-dependent diseases
DE60318447T2 (de) Pharmazeutische zusammensetzung enthaltend estetrolderivate und anwendung in der krebsbehandlung
DE60121980T2 (de) Verwendung von 11beta-(4-acetylphenyl)-17beta-hydroxy-17alpha-(1,1,2,2-pentafluoroethyl)estra-4,9-dien-3-on zur herstellung eines medikaments zur behandlung von brust-, eierstock-, endometrium-krebs, myelom und meningiom
DE60036723T2 (de) Mesoprogestine zur behandlung und vorbeugung von hormonabhängigen gutartigen gynekologischen störungen
EP1307229A1 (de) Kombinationspräparate aus einem er-beta-selektiven estrogen und einem serm oder antiestrogen
AU2002223619A1 (en) Use of antiprogestins for the induction of apoptosis in a cell
JP2010524998A (ja) Ｂｒｃａ介在性疾患における使用のための非ステロイド系抗エストロゲンを伴ったプロゲステロン受容体拮抗薬の組み合わせ
ZA200303793B (en) Use of antiprogestins for prophylaxis and treatment of hormone-dependent diseases.
DE4406915A1 (de) Ovulationshemmendes Mittel zur hormonalen Kontrazeption

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE

8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE