DE60115271D1 - Verfahren zur herstellung von seidenfibroinvliesstoffen - Google Patents

Verfahren zur herstellung von seidenfibroinvliesstoffen

Info

Publication number
DE60115271D1
DE60115271D1 DE60115271T DE60115271T DE60115271D1 DE 60115271 D1 DE60115271 D1 DE 60115271D1 DE 60115271 T DE60115271 T DE 60115271T DE 60115271 T DE60115271 T DE 60115271T DE 60115271 D1 DE60115271 D1 DE 60115271D1
Authority
DE
Germany
Prior art keywords
silk
liquids
kda
silk fibroin
producing silk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60115271T
Other languages
English (en)
Other versions
DE60115271T2 (de
Inventor
Ubaldo Armato
Pra Ilaria Dal
Kemal Kesenci
Claudio Migliaresi
Antonella Motta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CONSORZIO PER GLI STUDI UNIVER
Original Assignee
CONSORZIO PER GLI STUDI UNIVER
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CONSORZIO PER GLI STUDI UNIVER filed Critical CONSORZIO PER GLI STUDI UNIVER
Application granted granted Critical
Publication of DE60115271D1 publication Critical patent/DE60115271D1/de
Publication of DE60115271T2 publication Critical patent/DE60115271T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/225—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/40—Formation of filaments, threads, or the like by applying a shearing force to a dispersion or solution of filament formable polymers, e.g. by stirring
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F4/00—Monocomponent artificial filaments or the like of proteins; Manufacture thereof
    • D01F4/02—Monocomponent artificial filaments or the like of proteins; Manufacture thereof from fibroin
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
    • D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
    • D04H1/4266—Natural fibres not provided for in group D04H1/425
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H3/00—Non-woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length
    • D04H3/015—Natural yarns or filaments

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Textile Engineering (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Artificial Filaments (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
  • Woven Fabrics (AREA)
DE60115271T 2000-10-02 2001-09-28 Verfahren zur herstellung von seidenfibroinvliesstoffen Expired - Fee Related DE60115271T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2000VR000096A IT1316885B1 (it) 2000-10-02 2000-10-02 Procedimento per la preparazione di un tessuto non tessuto in fibroinadi seta.
ITVR000096 2000-10-02
PCT/IT2001/000501 WO2002029141A1 (en) 2000-10-02 2001-09-28 Method for the preparation of a non-woven silk fibroin fabrics

Publications (2)

Publication Number Publication Date
DE60115271D1 true DE60115271D1 (de) 2005-12-29
DE60115271T2 DE60115271T2 (de) 2006-08-24

Family

ID=11461889

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60115271T Expired - Fee Related DE60115271T2 (de) 2000-10-02 2001-09-28 Verfahren zur herstellung von seidenfibroinvliesstoffen

Country Status (8)

Country Link
US (1) US7285637B2 (de)
EP (1) EP1327014B1 (de)
AT (1) ATE310840T1 (de)
AU (1) AU2001295891A1 (de)
DE (1) DE60115271T2 (de)
ES (1) ES2254500T3 (de)
IT (1) IT1316885B1 (de)
WO (1) WO2002029141A1 (de)

Families Citing this family (51)

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Publication number Priority date Publication date Assignee Title
US20030129751A1 (en) * 2001-05-16 2003-07-10 Grikscheit Tracy C. Tissue-engineered organs
CN1277584C (zh) 2001-10-25 2006-10-04 康涅狄格大学 生物活性物质,制备生物活性物质的方法及其使用方法
US20110009960A1 (en) * 2001-11-16 2011-01-13 Allergan, Inc. Prosthetic fabric structure
US6902932B2 (en) * 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
JP2005515309A (ja) * 2002-01-09 2005-05-26 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー ポリペプチド繊維およびそれらの製造方法
EP2662211A1 (de) * 2002-06-24 2013-11-13 Tufts University Seidenbiomaterialien und Verfahren zu ihrer Verwendung
WO2004062697A2 (en) 2003-01-07 2004-07-29 Tufts University Silk fibroin materials and use thereof
DK1601826T3 (da) * 2003-03-11 2011-10-24 Allergan Inc Immunoneutrale medicinske anordninger på silkefiberbasis
CA2562415C (en) * 2003-04-10 2015-10-27 Tufts University Concentrated aqueous silk fibroin solutions free of organic solvents and uses thereof
WO2005000483A1 (en) * 2003-06-06 2005-01-06 Tufts University Method for forming inorganic coatings
WO2005123114A2 (en) 2004-06-11 2005-12-29 Trustees Of Tufts College Silk-based drug delivery system
KR100762928B1 (ko) 2004-10-29 2007-10-04 재단법인서울대학교산학협력재단 견 피브로인 나노섬유로 이루어진 부직포 형태의 골조직유도 재생용 차폐막 및 그 제조방법
EP2129772B1 (de) 2007-02-27 2016-07-27 Trustees Of Tufts College Gewebegezüchtete seidenorgane
US8172901B2 (en) 2007-03-20 2012-05-08 Allergan, Inc. Prosthetic device and method of manufacturing the same
ES2527125T3 (es) 2007-05-29 2015-01-20 Trustees Of Tufts College Método para la gelificación de fibroína de seda usando sonicación
CA2713251A1 (en) * 2008-02-07 2009-08-13 Trustees Of Tufts College 3-dimensional silk hydroxyapatite compositions
GB0807868D0 (en) 2008-04-30 2008-06-04 Knight David P Cartilage repair material and a method for the preparation thereof
WO2009140588A1 (en) * 2008-05-15 2009-11-19 Trustees Of Tufts College Silk polymer-based adenosine release: therapeutic potential for epilepsy
AU2009302192B2 (en) 2008-06-18 2014-08-28 Trustees Of Tufts College Modified silk films containing glycerol
US8501172B2 (en) 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
US9326840B2 (en) 2008-12-15 2016-05-03 Allergan, Inc. Prosthetic device and method of manufacturing the same
US9204953B2 (en) 2008-12-15 2015-12-08 Allergan, Inc. Biocompatible surgical scaffold with varying stretch
JP5653931B2 (ja) 2008-12-15 2015-01-14 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 補綴デバイスおよびその製作方法
US9204954B2 (en) 2008-12-15 2015-12-08 Allergan, Inc. Knitted scaffold with diagonal yarn
US9308070B2 (en) * 2008-12-15 2016-04-12 Allergan, Inc. Pliable silk medical device
WO2011008842A2 (en) 2009-07-14 2011-01-20 Trustees Of Tufts College Electrospun silk material systems for wound healing
AU2010292237A1 (en) * 2009-09-11 2012-04-05 Allergan, Inc. Prosthetic device and method of manufacturing the same
JP2013506058A (ja) * 2009-09-28 2013-02-21 タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ 延伸したシルクｅｇｅｌ繊維およびその製造方法
JP5730317B2 (ja) 2009-09-29 2015-06-10 タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ 絹ナノスフェアおよび絹マイクロスフェアならびにこれらを作製する方法
WO2011109691A2 (en) 2010-03-05 2011-09-09 Trustees Of Tufts College Silk-based ionomeric compositions
US8309689B2 (en) 2010-05-20 2012-11-13 Taipei Medical University High yield dialysis-free process for producing organosoluble regenerated silk fibroin
EP2611473A4 (de) 2010-09-01 2014-08-13 Tufts College Seidenfibroin und polyethylenglykol-biomaterialien
EP2629836B1 (de) 2010-10-19 2018-09-12 Trustees Of Tufts College Mikronadeln auf seidenfibroinbasis und verfahren zu ihrer herstellung
WO2012145652A1 (en) 2011-04-20 2012-10-26 Trustees Of Tufts College Dynamic silk coatings for implantable devices
WO2013119551A1 (en) 2012-02-06 2013-08-15 Children's Medical Center Corporation Multi-layer biomaterial for tissue regeneration and wound healing
US9925301B2 (en) 2012-04-06 2018-03-27 Trustees Of Tufts College Methods of producing and using silk microfibers
KR101313898B1 (ko) 2012-04-27 2013-09-30 서울대학교산학협력단 히알루론산―도파민 컨쥬게이트로 표면이 개질된 하이드록시아파타이트 나노입자를 포함하는 실크피브로인 나노섬유 및 이를 이용한 지지체
EP2712955A1 (de) 2012-09-27 2014-04-02 Ludwig Boltzmann Gesellschaft GmbH Produkt aus Seide
CN103446623B (zh) * 2013-09-18 2015-03-11 中国人民解放军军事医学科学院卫生装备研究所 一种组织工程表皮模型的构建方法
CN103668782B (zh) * 2013-11-29 2016-05-11 温州医科大学 超薄多孔复合纳米纤维仿生Bruch’s膜的静电纺丝制备方法
KR101573838B1 (ko) * 2014-06-13 2015-12-07 대한민국 누에고치를 이용한 인공 생체막 및 이의 제조방법
KR101714545B1 (ko) * 2014-06-26 2017-03-15 대한민국 골조직 형성 촉진용 차폐막의 제조방법 및 이를 이용하여 제조된 골조직 형성 촉진용 차폐막
KR101570717B1 (ko) 2014-08-04 2015-11-24 대한민국 누에고치를 이용한 치과용 차폐막 및 이의 제조방법
US9394355B2 (en) 2014-08-20 2016-07-19 Silk Technologies, Ltd. Fibroin-derived protein composition
WO2016172689A1 (en) 2015-04-23 2016-10-27 Rowan University Processes of increasing crystallinity alignment of protein films and products thereof
CA3018447A1 (en) * 2016-03-31 2017-10-05 Ear Science Institute Australia Improved silk fibroin glycerol membranes
WO2018006037A1 (en) * 2016-07-01 2018-01-04 Trustees Of Tufts College Innervated artificial skin
US11242367B2 (en) 2016-08-12 2022-02-08 Silk Technologies, Ltd. Silk-derived protein for treating inflammation
US11549198B2 (en) 2017-04-17 2023-01-10 Rowan University Method of producing non-woven protein fibers
US20200188178A1 (en) * 2018-12-18 2020-06-18 National Taiwan University Of Science And Technology Double-layer dressing containing silk fibroin and a method for making the same
CN116392636A (zh) * 2023-03-29 2023-07-07 深圳高性能医疗器械国家研究院有限公司 蚕丝修复补片及其制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US976977A (en) * 1908-11-27 1910-11-29 Carl Rudolf Baumann Process for obtaining silk fibroin.
US5171505A (en) * 1990-11-28 1992-12-15 E. I. Du Pont De Nemours And Company Process for spinning polypeptide fibers
DE19841649A1 (de) * 1998-09-11 2000-04-27 Thueringisches Inst Textil Verfahren zur Herstellung und produktorientierten Verarbeitung von konzentrierten Lösungen fibrillärer Proteine in NMMNO-Monohydrat

Also Published As

Publication number Publication date
DE60115271T2 (de) 2006-08-24
IT1316885B1 (it) 2003-05-13
ES2254500T3 (es) 2006-06-16
US7285637B2 (en) 2007-10-23
EP1327014B1 (de) 2005-11-23
AU2001295891A1 (en) 2002-04-15
WO2002029141A1 (en) 2002-04-11
ITVR20000096A0 (it) 2000-10-02
ITVR20000096A1 (it) 2002-04-02
US20040097709A1 (en) 2004-05-20
EP1327014A1 (de) 2003-07-16
ATE310840T1 (de) 2005-12-15

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