DE60111948D1 - Benzoltricarbonsäureamide als aktivatoren des insulinrezeptors - Google Patents

Benzoltricarbonsäureamide als aktivatoren des insulinrezeptors

Info

Publication number
DE60111948D1
DE60111948D1 DE60111948T DE60111948T DE60111948D1 DE 60111948 D1 DE60111948 D1 DE 60111948D1 DE 60111948 T DE60111948 T DE 60111948T DE 60111948 T DE60111948 T DE 60111948T DE 60111948 D1 DE60111948 D1 DE 60111948D1
Authority
DE
Germany
Prior art keywords
benzolic
acetic acid
acid amides
insulin receptor
receptor activators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60111948T
Other languages
English (en)
Other versions
DE60111948T2 (de
Inventor
Louise Robinson
Nicholas Cairns
Prasad V V S V Manchem
Steven R Chow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc filed Critical Telik Inc
Publication of DE60111948D1 publication Critical patent/DE60111948D1/de
Application granted granted Critical
Publication of DE60111948T2 publication Critical patent/DE60111948T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60111948T 2000-09-07 2001-09-06 Benzoltricarbonsäureamide als aktivatoren des insulinrezeptors Expired - Fee Related DE60111948T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23073800P 2000-09-07 2000-09-07
US230738P 2000-09-07
PCT/US2001/028084 WO2002020464A2 (en) 2000-09-07 2001-09-06 Benzene tricarboxylic acid amides as insulin receptor activators

Publications (2)

Publication Number Publication Date
DE60111948D1 true DE60111948D1 (de) 2005-08-18
DE60111948T2 DE60111948T2 (de) 2006-04-20

Family

ID=22866366

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60111948T Expired - Fee Related DE60111948T2 (de) 2000-09-07 2001-09-06 Benzoltricarbonsäureamide als aktivatoren des insulinrezeptors

Country Status (12)

Country Link
US (1) US6600069B2 (de)
EP (1) EP1315695B1 (de)
JP (1) JP2004508348A (de)
AR (1) AR030620A1 (de)
AT (1) ATE299491T1 (de)
AU (1) AU8889101A (de)
CA (1) CA2421581A1 (de)
DE (1) DE60111948T2 (de)
DK (1) DK1315695T3 (de)
ES (1) ES2241867T3 (de)
TW (1) TWI283660B (de)
WO (1) WO2002020464A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1391474B1 (it) * 2008-10-02 2011-12-23 Università Degli Studi Di Roma La Sapienza Derivati carbonilici a simmetria c3, loro preparazione e loro uso
KR101121954B1 (ko) 2010-05-13 2012-03-09 아주대학교산학협력단 1,2,3-Ｂｅｎｚｅｎｔｒｉｃａｒｂｏｘｙｌｉｃ ａｃｉｄ를 유효성분으로 포함하는 당뇨병 예방 또는 치료용 조성물
JP6255210B2 (ja) * 2013-10-24 2017-12-27 アーゼッド・エレクトロニック・マテリアルズ（ルクセンブルグ）ソシエテ・ア・レスポンサビリテ・リミテ レジスト下層膜形成組成物

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046805A (en) 1976-05-10 1977-09-06 American Cyanamid Company Substituted-hydroxy-naphthalenedisulfonic acid compounds
US4051176A (en) 1976-05-10 1977-09-27 American Cyanamid Company Ureidophenylenebis(carbonylimino)dinaphthalenetrisulfonic acid compounds
US4129591A (en) 1976-10-27 1978-12-12 American Cyanamid Company Ureida-phenylenebis(substituted imino)multianionic substituted dinaphthalene sulfonic acids and salts
US4102917A (en) 1977-06-01 1978-07-25 American Cyanamid Company Substituted phenyl naphthalenesulfonic acids
US4123455A (en) * 1977-06-13 1978-10-31 American Cyanamid Company Phenenyltris(carbonylimino) multi-anionic substituted triphenyl acids and salts
US4089974A (en) * 1977-06-13 1978-05-16 American Cyanamid Company 5-Carboxy-phenylenebis(carbonylimino)benzene carboxylic and dicarboxylic acids and salts
US4120895A (en) 1977-06-29 1978-10-17 American Cyanamid Company S-phenenyltris (iminocarbonyl) triisophthalic acid salts
US4132730A (en) 1977-07-29 1979-01-02 American Cyanamid Company Ureylene naphthalene sulfonic acids
US4120891A (en) 1977-07-01 1978-10-17 American Cyanamid Company Ureylene naphthalene sulfonic acids
US4118585A (en) 1977-07-01 1978-10-03 American Cyanamid Company Anionic benzene tetrakis carbonylimino isophthalic acid salts
US4229371A (en) * 1977-07-29 1980-10-21 American Cyanamid Company Ureylene naphthalene sulfonic acid intermediates
CH654853A5 (de) * 1982-08-07 1986-03-14 Sandoz Ag Verfahren zum verdichten von anodisch oxydierten aluminiumoberflaechen.
DE4229182A1 (de) * 1992-09-02 1994-03-03 Basf Ag Metallchelate
US5599984A (en) * 1994-01-21 1997-02-04 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
US5973076A (en) * 1995-05-31 1999-10-26 New Japan Chemical Co., Ltd. Polybutene-1 resin composition and a method of accelerating the crystal transformation thereof
US5565432A (en) * 1994-11-07 1996-10-15 American Home Products Corporation Smooth muscle cell proliferation inhibitors
TR199600329A2 (tr) 1995-05-05 1997-03-21 Hoffmann La Roche Seker alkollerin yeni sülfürik asit esterleri.
JPH08333324A (ja) * 1995-06-08 1996-12-17 Terumo Corp ベンゼン誘導体およびそれを含有する医薬製剤
JP3836910B2 (ja) * 1996-01-19 2006-10-25 富士写真フイルム株式会社 ハロゲン化銀写真感光材料およびその処理方法
EP1277790A3 (de) 1998-03-04 2004-07-28 Ciba SC Holding AG Nukleierungsmittel zur Kristallisation thermoplastischer Polymere
UA74555C2 (en) * 1999-07-29 2006-01-16 Telik Inc Naphthyl-sulfonic acids and related compounds as agonists of glucose uptake, pharmaceutical composition and method for treatment

Also Published As

Publication number Publication date
ES2241867T3 (es) 2005-11-01
WO2002020464A8 (en) 2003-07-10
WO2002020464A3 (en) 2002-06-20
US6600069B2 (en) 2003-07-29
WO2002020464A2 (en) 2002-03-14
US20020103183A1 (en) 2002-08-01
TWI283660B (en) 2007-07-11
ATE299491T1 (de) 2005-07-15
EP1315695A2 (de) 2003-06-04
DK1315695T3 (da) 2005-08-08
EP1315695B1 (de) 2005-07-13
AR030620A1 (es) 2003-08-27
CA2421581A1 (en) 2002-03-14
AU8889101A (en) 2002-03-22
DE60111948T2 (de) 2006-04-20
JP2004508348A (ja) 2004-03-18

Similar Documents

Publication Publication Date Title
ATE374768T1 (de) Indole-3-carbonsaüreamide als glucokinase (gk) aktivatoren
DE60108108D1 (de) Heteroaromatische alkynylphenyl-verbindungen als glukokinase-aktivatoren
ATE260914T1 (de) Triazolyltropanderivate als ccr5-modulatoren
DE60014610D1 (de) Glukokinase aktivatoren
NO20022863L (no) Trans-olefiniske glycokinase aktivatorer
NO20013138L (no) Innholdsforsyningssystem
NO20034196D0 (no) Vinylester karbamid
DE60111534D1 (de) Alpha-acyl- und alpha-heteroatom-substituierte benzenacetamide verwendbar als glucokinase-aktivatoren
ATE297921T1 (de) Tetrazolylphenyl-acetamide als glukokinaseaktivatoren
ATE339417T1 (de) Biphenyl - sulfonamide als duale angiotensin - endothelin - rezeptor - antagonisten
DE60134470D1 (de) Para-amin substituierte phenylamid glukokinase activatoren
DE60134094D1 (de) C7-taxanester als antitumormittel
DE50002364D1 (de) Abgewandelte aminosäureamide als cgrp antagonisten
DE50212761D1 (de) Neuartige aminodicarbonsäurederivate
FI20002590A (fi) Tuloilmalaite
DE60124296D1 (de) Biphenylcarbonsäureamide, die sich als lipidsenker eignen
FI20002677A (fi) Tuloilmalaite
DE50003445D1 (de) Substituierte benzoylpyrazole als herbizide
FI990362A0 (fi) Tuloilmalaite
DK1444205T3 (da) Fremgangsmåde til fremstilling af 2-halogenpyridincarboxylsyreamider
ATE421515T1 (de) Carbonsäureamide
DE60003072D1 (de) Thiazolidindion-derivate als antidiabetika
DE60111948D1 (de) Benzoltricarbonsäureamide als aktivatoren des insulinrezeptors
FI20000813A0 (fi) Tuloilmalaite
DE50016096D1 (de) Versorgungseinheit

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee