DE60109741T8 - Verfahren zur vermeidung von fluoreszenzlöschung - Google Patents

Verfahren zur vermeidung von fluoreszenzlöschung Download PDF

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Publication number
DE60109741T8
DE60109741T8 DE60109741T DE60109741T DE60109741T8 DE 60109741 T8 DE60109741 T8 DE 60109741T8 DE 60109741 T DE60109741 T DE 60109741T DE 60109741 T DE60109741 T DE 60109741T DE 60109741 T8 DE60109741 T8 DE 60109741T8
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DE
Germany
Prior art keywords
therapy
detection
imaging
dyes
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE60109741T
Other languages
German (de)
English (en)
Other versions
DE60109741D1 (de
DE60109741T2 (de
Inventor
I. Samuel ACHILEFU
Raghavan Rajagopalan
B. Richard DORSHOW
E. Joseph BUGAJ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of DE60109741D1 publication Critical patent/DE60109741D1/de
Application granted granted Critical
Publication of DE60109741T2 publication Critical patent/DE60109741T2/de
Publication of DE60109741T8 publication Critical patent/DE60109741T8/de
Active legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Endoscopes (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE60109741T 2000-01-18 2001-01-17 Verfahren zur vermeidung von fluoreszenzlöschung Active DE60109741T8 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/484,323 US6190641B1 (en) 2000-01-18 2000-01-18 Indocyanine dyes
US484323 2000-01-18
PCT/US2001/001470 WO2001062156A1 (en) 2000-01-18 2001-01-17 Novel indocyanine dyes

Publications (3)

Publication Number Publication Date
DE60109741D1 DE60109741D1 (de) 2005-05-04
DE60109741T2 DE60109741T2 (de) 2006-02-23
DE60109741T8 true DE60109741T8 (de) 2006-04-27

Family

ID=23923670

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60109741T Active DE60109741T8 (de) 2000-01-18 2001-01-17 Verfahren zur vermeidung von fluoreszenzlöschung

Country Status (8)

Country Link
US (2) US6190641B1 (https=)
EP (2) EP1561425A1 (https=)
JP (1) JP2003523371A (https=)
AT (1) ATE291879T1 (https=)
AU (1) AU2001232820A1 (https=)
DE (1) DE60109741T8 (https=)
ES (1) ES2239123T3 (https=)
WO (1) WO2001062156A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133445A (en) 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes
WO2004039894A2 (en) 2002-05-10 2004-05-13 Carnegie Mellon University Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups
US6939532B2 (en) * 2000-01-18 2005-09-06 Mallinckrodt, Inc. Versatile hydrophilic dyes
US6395257B1 (en) 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US20080233050A1 (en) * 2000-01-18 2008-09-25 Mallinckrodt Inc. Diagnostic and therapeutic optical agents
US6190641B1 (en) * 2000-01-18 2001-02-20 Mallinckrodt Inc. Indocyanine dyes
US6663847B1 (en) * 2000-10-13 2003-12-16 Mallinckrodt Inc. Dynamic organ function monitoring agents
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US7556797B2 (en) * 2000-10-16 2009-07-07 Mallinckrodt Inc. Minimally invasive physiological function monitoring agents
US6485704B1 (en) * 2001-05-04 2002-11-26 Mallinckrodt Inc. Azo compound for type I pototherapy
US6761878B2 (en) * 2001-10-17 2004-07-13 Mallinckrodt, Inc. Pathological tissue detection and treatment employing targeted benzoindole optical agents
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
WO2004068405A2 (en) * 2003-01-25 2004-08-12 Oraevsky Alexander A High contrast optoacoustical imaging using nanoparticles
US20100022449A1 (en) * 2006-03-09 2010-01-28 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
JP5349839B2 (ja) * 2007-06-22 2013-11-20 キヤノン株式会社 生体情報イメージング装置
US9433700B2 (en) 2009-04-27 2016-09-06 Medibeacon Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
US9138492B2 (en) 2012-02-23 2015-09-22 Canon Kabushiki Kaisha Particle containing hydrophobic dye having cyanine structure, and contrast agent containing the particle

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2919447A1 (de) * 1978-05-17 1979-11-22 Takeda Chemical Industries Ltd Tumorhemmendes mittel
JPS59192595A (ja) * 1983-04-16 1984-10-31 Tdk Corp 光記録媒体
JPS62220962A (ja) * 1986-03-24 1987-09-29 Oji Paper Co Ltd レ−ザ−光用電子写真感光体
JP3354975B2 (ja) * 1992-10-06 2002-12-09 イビデン株式会社 蛍光標識試薬および蛍光免疫測定法
KR100397020B1 (ko) * 1995-01-30 2004-04-29 다이이치 가가쿠 야쿠힝 가부시키가이샤 진단용마커
JP3669752B2 (ja) * 1995-01-30 2005-07-13 第一化学薬品株式会社 診断用マーカー
JPH09227378A (ja) * 1996-02-20 1997-09-02 Fuji Photo Film Co Ltd 抗癌性組成物
JPH106653A (ja) * 1996-06-25 1998-01-13 Fuji Photo Film Co Ltd 情報記録媒体
US6217848B1 (en) * 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications
US6190641B1 (en) * 2000-01-18 2001-02-20 Mallinckrodt Inc. Indocyanine dyes

Also Published As

Publication number Publication date
US6190641B1 (en) 2001-02-20
EP1250093A4 (en) 2003-05-07
ES2239123T3 (es) 2005-09-16
EP1250093A1 (en) 2002-10-23
EP1561425A1 (en) 2005-08-10
US6264919B1 (en) 2001-07-24
DE60109741D1 (de) 2005-05-04
AU2001232820A1 (en) 2001-09-03
ATE291879T1 (de) 2005-04-15
WO2001062156A1 (en) 2001-08-30
JP2003523371A (ja) 2003-08-05
DE60109741T2 (de) 2006-02-23
EP1250093B1 (en) 2005-03-30

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