DE60109047D1 - Synthone zur herstellung von oligonukleotiden - Google Patents

Synthone zur herstellung von oligonukleotiden

Info

Publication number
DE60109047D1
DE60109047D1 DE60109047T DE60109047T DE60109047D1 DE 60109047 D1 DE60109047 D1 DE 60109047D1 DE 60109047 T DE60109047 T DE 60109047T DE 60109047 T DE60109047 T DE 60109047T DE 60109047 D1 DE60109047 D1 DE 60109047D1
Authority
DE
Germany
Prior art keywords
trivalent phosphorus
synthone
oligonucleotides
manufacture
phosphorus multimer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60109047T
Other languages
English (en)
Other versions
DE60109047T2 (de
Inventor
Nanda Sinha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitto Denko Avecia Inc
Original Assignee
Avecia Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Biotechnology Inc filed Critical Avecia Biotechnology Inc
Application granted granted Critical
Publication of DE60109047D1 publication Critical patent/DE60109047D1/de
Publication of DE60109047T2 publication Critical patent/DE60109047T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
DE60109047T 2000-09-07 2001-09-06 Synthone zur herstellung von oligonukleotiden Expired - Fee Related DE60109047T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23068500P 2000-09-07 2000-09-07
US230685P 2000-09-07
PCT/GB2001/003973 WO2002020543A2 (en) 2000-09-07 2001-09-06 Synthons for oligonucleotide synthesis

Publications (2)

Publication Number Publication Date
DE60109047D1 true DE60109047D1 (de) 2005-03-31
DE60109047T2 DE60109047T2 (de) 2006-04-06

Family

ID=22866178

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60109047T Expired - Fee Related DE60109047T2 (de) 2000-09-07 2001-09-06 Synthone zur herstellung von oligonukleotiden

Country Status (10)

Country Link
US (1) US20030229218A1 (de)
EP (1) EP1317466B1 (de)
JP (1) JP2004508379A (de)
KR (1) KR20030081303A (de)
CN (1) CN1471537A (de)
AT (1) ATE289610T1 (de)
AU (1) AU2001284268A1 (de)
CA (1) CA2421489A1 (de)
DE (1) DE60109047T2 (de)
WO (1) WO2002020543A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0209539D0 (en) * 2002-04-26 2002-06-05 Avecia Ltd Monomer Polymer and process
WO2005027962A1 (en) * 2003-09-18 2005-03-31 Isis Pharmaceuticals, Inc. 4’-thionucleosides and oligomeric compounds
JP4628686B2 (ja) * 2004-02-25 2011-02-09 独立行政法人科学技術振興機構 ホスホロアミダイトを含む３’末端ヌクレオシドユニット
JP5195757B2 (ja) * 2007-08-31 2013-05-15 富士通株式会社 核酸合成用ダイマーアミダイド及び核酸合成方法
KR100886139B1 (ko) * 2007-11-13 2009-02-27 주식회사 삼천리제약 올리고뉴클레오타이드의 제조방법
EP3004131B1 (de) 2013-06-05 2020-07-22 AM Chemicals Llc Phosphoramidit-bausteine für zuckerkonjugierte oligonukleotide
CN110023321A (zh) 2016-08-17 2019-07-16 索尔斯蒂斯生物有限公司 多核苷酸构建体
US11597744B2 (en) 2017-06-30 2023-03-07 Sirius Therapeutics, Inc. Chiral phosphoramidite auxiliaries and methods of their use
WO2019158007A1 (zh) * 2018-02-13 2019-08-22 深圳华大生命科学研究院 合成寡核苷酸的方法及系统
US11166976B2 (en) 2018-11-08 2021-11-09 Aligos Therapeutics, Inc. S-antigen transport inhibiting oligonucleotide polymers and methods
EP3805242A1 (de) * 2019-10-07 2021-04-14 Sterna Biologicals GmbH & Co. KG Verfahren zur herstellung eines katalytisch aktiven dna-moleküls mit verbesserter aktivität und dessen verwendung in einem verfahren zur behandlung von asthma
JPWO2021141072A1 (de) 2020-01-08 2021-07-15

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX158743A (es) * 1980-02-29 1989-03-10 University Patents Inc Procedimiento para la produccion de oligonucleotidos
EP0090789A1 (de) * 1982-03-26 1983-10-05 Monsanto Company Chemische DNA-Synthese
US5449769A (en) * 1989-03-06 1995-09-12 Gen-Probe Incorporated Method and reagent for sulfurization of organophosphorous compounds
US5218088A (en) * 1989-11-02 1993-06-08 Purdue Research Foundation Process for preparing dithiophosphate oligonucleotide analogs via nucleoside thiophosphoramidite intermediates
WO1993013121A1 (en) * 1991-12-24 1993-07-08 Isis Pharmaceuticals, Inc. Gapped 2' modified oligonucleotides
WO1994000472A2 (en) * 1992-06-30 1994-01-06 Research Corporation Technologies, Inc. Trivalent synthesis of oligonucleotides containing stereospecific alkylphosphonates and arylphosphonates
US6087491A (en) * 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
US5856464A (en) * 1995-06-07 1999-01-05 Lajolla Pharmaceutical Company Selective capping solution phase oligonucleotide synthesis
JP4151751B2 (ja) * 1999-07-22 2008-09-17 第一三共株式会社 新規ビシクロヌクレオシド類縁体

Also Published As

Publication number Publication date
DE60109047T2 (de) 2006-04-06
EP1317466A2 (de) 2003-06-11
WO2002020543A2 (en) 2002-03-14
CN1471537A (zh) 2004-01-28
KR20030081303A (ko) 2003-10-17
ATE289610T1 (de) 2005-03-15
WO2002020543A3 (en) 2002-08-08
JP2004508379A (ja) 2004-03-18
EP1317466B1 (de) 2005-02-23
AU2001284268A1 (en) 2002-03-22
CA2421489A1 (en) 2002-03-14
US20030229218A1 (en) 2003-12-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee