DE60107413D1 - Verfahren zum nachweis von agentien die die aktivität der promotersequenz des crf-2 alpha rezeptors verändern - Google Patents

Verfahren zum nachweis von agentien die die aktivität der promotersequenz des crf-2 alpha rezeptors verändern

Info

Publication number
DE60107413D1
DE60107413D1 DE60107413T DE60107413T DE60107413D1 DE 60107413 D1 DE60107413 D1 DE 60107413D1 DE 60107413 T DE60107413 T DE 60107413T DE 60107413 T DE60107413 T DE 60107413T DE 60107413 D1 DE60107413 D1 DE 60107413D1
Authority
DE
Germany
Prior art keywords
cell line
promoter sequence
crf
change
transgenic animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60107413T
Other languages
English (en)
Inventor
H Kalin
H Roseboom
F Landry
A Nanda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE60107413D1 publication Critical patent/DE60107413D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE60107413T 2000-05-02 2001-04-30 Verfahren zum nachweis von agentien die die aktivität der promotersequenz des crf-2 alpha rezeptors verändern Expired - Lifetime DE60107413D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20112900P 2000-05-02 2000-05-02
PCT/US2001/013920 WO2001083563A2 (en) 2000-05-02 2001-04-30 Method of identifying agents that alter the activity of the promoter sequence for crf receptor 2-alpha

Publications (1)

Publication Number Publication Date
DE60107413D1 true DE60107413D1 (de) 2004-12-30

Family

ID=22744599

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60107413T Expired - Lifetime DE60107413D1 (de) 2000-05-02 2001-04-30 Verfahren zum nachweis von agentien die die aktivität der promotersequenz des crf-2 alpha rezeptors verändern

Country Status (8)

Country Link
US (1) US20020032912A1 (de)
EP (1) EP1279038B1 (de)
JP (1) JP2003531601A (de)
AT (1) ATE283480T1 (de)
AU (1) AU2001295192A1 (de)
CA (1) CA2407834A1 (de)
DE (1) DE60107413D1 (de)
WO (1) WO2001083563A2 (de)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965790A (en) * 1997-03-06 1999-10-12 Millennium Pharmaceuticals, Inc. SR-BI regulatory sequences and therapeutic methods of use

Also Published As

Publication number Publication date
EP1279038B1 (de) 2004-11-24
WO2001083563A3 (en) 2002-07-04
ATE283480T1 (de) 2004-12-15
US20020032912A1 (en) 2002-03-14
AU2001295192A1 (en) 2001-11-12
WO2001083563A2 (en) 2001-11-08
JP2003531601A (ja) 2003-10-28
CA2407834A1 (en) 2001-11-08
EP1279038A2 (de) 2003-01-29

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Legal Events

Date Code Title Description
8332 No legal effect for de