DE60106947T2 - Oxindolderivate - Google Patents
Oxindolderivate Download PDFInfo
- Publication number
- DE60106947T2 DE60106947T2 DE60106947T DE60106947T DE60106947T2 DE 60106947 T2 DE60106947 T2 DE 60106947T2 DE 60106947 T DE60106947 T DE 60106947T DE 60106947 T DE60106947 T DE 60106947T DE 60106947 T2 DE60106947 T2 DE 60106947T2
- Authority
- DE
- Germany
- Prior art keywords
- pyrrolo
- dihydro
- methylidene
- quinolin
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 125000004095 oxindolyl group Chemical class N1(C(CC2=CC=CC=C12)=O)* 0.000 title abstract description 7
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- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 claims abstract description 40
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- 150000001875 compounds Chemical class 0.000 claims description 108
- -1 methoxyethyl Chemical group 0.000 claims description 55
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 30
- 150000001408 amides Chemical class 0.000 claims description 28
- 150000002148 esters Chemical class 0.000 claims description 28
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 24
- 229910052757 nitrogen Inorganic materials 0.000 claims description 24
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- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
- 125000001072 heteroaryl group Chemical group 0.000 claims description 13
- 125000001424 substituent group Chemical group 0.000 claims description 13
- 125000005843 halogen group Chemical group 0.000 claims description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 10
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- MNRILEROXIRVNJ-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=NC=N[C]21 MNRILEROXIRVNJ-UHFFFAOYSA-N 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 description 1
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- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23024100P | 2000-09-01 | 2000-09-01 | |
| US230241P | 2000-09-01 | ||
| PCT/US2001/020703 WO2002020524A1 (en) | 2000-09-01 | 2001-06-28 | Oxindole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60106947D1 DE60106947D1 (de) | 2004-12-09 |
| DE60106947T2 true DE60106947T2 (de) | 2005-11-10 |
Family
ID=22864461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60106947T Expired - Fee Related DE60106947T2 (de) | 2000-09-01 | 2001-06-28 | Oxindolderivate |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6720332B2 (enExample) |
| EP (1) | EP1313732B1 (enExample) |
| JP (1) | JP2004508372A (enExample) |
| AT (1) | ATE281455T1 (enExample) |
| AU (1) | AU2001271611A1 (enExample) |
| DE (1) | DE60106947T2 (enExample) |
| ES (1) | ES2230337T3 (enExample) |
| WO (1) | WO2002020524A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60041399D1 (de) * | 1999-05-19 | 2009-03-05 | Painceptor Pharma Corp | Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen |
| JP4291696B2 (ja) | 2002-01-22 | 2009-07-08 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | ２−（ピリジン−２−イルアミノ）−ピリド［２，３−ｄ］ピリミジン−７−オン |
| JP4053073B2 (ja) * | 2003-07-11 | 2008-02-27 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 選択的ｃｄｋ４阻害剤のイセチオン酸塩 |
| US20050171182A1 (en) * | 2003-12-11 | 2005-08-04 | Roger Briesewitz | Methods and compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases |
| US7304074B2 (en) | 2005-04-05 | 2007-12-04 | Hoffmann-La Roche Inc. | Substituted 1,5-naphthyridine azolinones |
| EP3399026B1 (en) | 2010-06-14 | 2024-06-26 | The Scripps Research Institute | Reprogramming of cells to a new fate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9716557D0 (en) * | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| GB9904933D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
-
2001
- 2001-06-28 AT AT01950642T patent/ATE281455T1/de not_active IP Right Cessation
- 2001-06-28 DE DE60106947T patent/DE60106947T2/de not_active Expired - Fee Related
- 2001-06-28 EP EP01950642A patent/EP1313732B1/en not_active Expired - Lifetime
- 2001-06-28 ES ES01950642T patent/ES2230337T3/es not_active Expired - Lifetime
- 2001-06-28 AU AU2001271611A patent/AU2001271611A1/en not_active Abandoned
- 2001-06-28 US US10/362,744 patent/US6720332B2/en not_active Expired - Fee Related
- 2001-06-28 JP JP2002525145A patent/JP2004508372A/ja active Pending
- 2001-06-28 WO PCT/US2001/020703 patent/WO2002020524A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004508372A (ja) | 2004-03-18 |
| DE60106947D1 (de) | 2004-12-09 |
| WO2002020524A1 (en) | 2002-03-14 |
| ATE281455T1 (de) | 2004-11-15 |
| EP1313732A1 (en) | 2003-05-28 |
| US6720332B2 (en) | 2004-04-13 |
| US20030195189A1 (en) | 2003-10-16 |
| ES2230337T3 (es) | 2005-05-01 |
| EP1313732B1 (en) | 2004-11-03 |
| AU2001271611A1 (en) | 2002-03-22 |
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