DE60103061D1 - Verfahren zur identifizierung von verbindungen, die den anaphase-fördernden komplex hemmen - Google Patents

Verfahren zur identifizierung von verbindungen, die den anaphase-fördernden komplex hemmen

Info

Publication number
DE60103061D1
DE60103061D1 DE60103061T DE60103061T DE60103061D1 DE 60103061 D1 DE60103061 D1 DE 60103061D1 DE 60103061 T DE60103061 T DE 60103061T DE 60103061 T DE60103061 T DE 60103061T DE 60103061 D1 DE60103061 D1 DE 60103061D1
Authority
DE
Germany
Prior art keywords
inhibit
identifying compounds
anaphase
promoting complex
apc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60103061T
Other languages
English (en)
Other versions
DE60103061T2 (de
Inventor
Michael Gmachl
Jan-Michael Peters
Christian Gieffers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Application granted granted Critical
Publication of DE60103061D1 publication Critical patent/DE60103061D1/de
Publication of DE60103061T2 publication Critical patent/DE60103061T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/9015—Ligases (6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE60103061T 2000-06-29 2001-06-27 Verfahren zur identifizierung von verbindungen, die den anaphase-fördernden komplex hemmen Expired - Fee Related DE60103061T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00113832 2000-06-29
EP00113832A EP1167539A1 (de) 2000-06-29 2000-06-29 Verfahren zur Identifizierung von Verbindungen die das Anaphae-fördernde Komplex hemmen
PCT/EP2001/007329 WO2002000923A1 (en) 2000-06-29 2001-06-27 Methods for identifying inhibitors of the anaphase promoting complex

Publications (2)

Publication Number Publication Date
DE60103061D1 true DE60103061D1 (de) 2004-06-03
DE60103061T2 DE60103061T2 (de) 2004-09-02

Family

ID=8169106

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60103061T Expired - Fee Related DE60103061T2 (de) 2000-06-29 2001-06-27 Verfahren zur identifizierung von verbindungen, die den anaphase-fördernden komplex hemmen

Country Status (7)

Country Link
EP (2) EP1167539A1 (de)
JP (1) JP2004501655A (de)
AT (1) ATE265543T1 (de)
AU (1) AU2001279695A1 (de)
DE (1) DE60103061T2 (de)
DK (1) DK1299559T3 (de)
WO (1) WO2002000923A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6740495B1 (en) 2000-04-03 2004-05-25 Rigel Pharmaceuticals, Inc. Ubiquitin ligase assay
US6979551B2 (en) * 2000-04-03 2005-12-27 Rigel Pharmaceuticals, Inc. Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents
WO2003000726A1 (en) * 2001-06-22 2003-01-03 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Crystal structure of the apc10/doc1 subunit of the human anaphase-promoting complex
EP1469082A1 (de) * 2003-04-16 2004-10-20 Boehringer Ingelheim International GmbH Methode zur Identifizierung von Substanzen die den anaphase Promotionskomplex spezifisch inhibieren.
CN104877017A (zh) * 2015-05-06 2015-09-02 东南大学 一种抗肿瘤泛素化蛋白及其提取方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726025A (en) * 1995-04-20 1998-03-10 President And Fellows Of Harvard College Assay and reagents for detecting inhibitors of ubiquitin-dependent degradation of cell cycle regulatory proteins
NZ332482A (en) * 1996-04-01 2000-05-26 Rappaport Family Inst For Res Human and clam cyclin-selective ubiquitin carrier polypeptides (E2) that are involved in the ubiquitination of cyclins A and B, inhibitors of these E2 polypeptides are included
EP0843008A1 (de) * 1996-11-14 1998-05-20 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Herstellung von dem Anaphase-fördernden Komplex

Also Published As

Publication number Publication date
DE60103061T2 (de) 2004-09-02
WO2002000923A1 (en) 2002-01-03
EP1299559B1 (de) 2004-04-28
EP1299559A1 (de) 2003-04-09
ATE265543T1 (de) 2004-05-15
AU2001279695A1 (en) 2002-01-08
DK1299559T3 (da) 2004-07-26
JP2004501655A (ja) 2004-01-22
EP1167539A1 (de) 2002-01-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee